N352 FINAL EXAM: AUTOIMMUNE & CANCER
PHARMACOLOGY | NURSING STUDY GUIDE,
PRACTICE QUESTIONS & ANSWERS
2026/2027
1 of 40
Term
Chemotherapy
Give this one a go later!
• Rheumatoid Arthritis • Rheumatoid Arthritis
• Cancer • Crohn disease
• Systemic lupus erythematosus Ulcerative colitis
• Infusion reaction
• Infection
• Hypersensitivity reaction • use of medications to treat
• N/D cancer
• Insomnia • Damage or kill cancer cells
• Depression
• Migraines
, Don't know?
2 of 40
Term
Methotrexate considerations
Give this one a go later!
Inhibits DNA synthesis, repair, and cellular replication. Unknown for RA, thought to
affect immune function
• Most regimens involve combination of drugs with differing cellular action.
• Drug resistance is a major problem.
• Newer drugs used after primary medications become ineffective.
• Closely monitor for toxicities
• Risks of co-administration with NSAIDs
• Verify dosing schedule
Contraindicated in pregnancy
• Assess for patent IV with positive blood return
• Assess for appropriate site selection
• Central lines should be required for vesicant administration
Don't know?
, 3 of 40
Term
Methotrexate AE
Give this one a go later!
• Assess for patent IV with positive blood return
• Assess for appropriate site selection
• Central lines should be required for vesicant administration
Inhibits DNA synthesis, repair, and cellular replication. Unknown for RA, thought to
affect immune function
• Dependent on:
- Type, stage of cancer
- Drug efficacy in specific cancer
- Patient's age, health status
• Including liver, kidney function
• Dose must be carefully calculated to minimize toxicity
• Severe bone marrow suppression
• Thrombosis
• Pruritus and photosensitivity
• Stevens-Johnson syndrome and toxic epidermal necrolysis
• N/V/D
• Blood dyscrasias
• Elevated LFTs
• Renal failure
• Infections
PHARMACOLOGY | NURSING STUDY GUIDE,
PRACTICE QUESTIONS & ANSWERS
2026/2027
1 of 40
Term
Chemotherapy
Give this one a go later!
• Rheumatoid Arthritis • Rheumatoid Arthritis
• Cancer • Crohn disease
• Systemic lupus erythematosus Ulcerative colitis
• Infusion reaction
• Infection
• Hypersensitivity reaction • use of medications to treat
• N/D cancer
• Insomnia • Damage or kill cancer cells
• Depression
• Migraines
, Don't know?
2 of 40
Term
Methotrexate considerations
Give this one a go later!
Inhibits DNA synthesis, repair, and cellular replication. Unknown for RA, thought to
affect immune function
• Most regimens involve combination of drugs with differing cellular action.
• Drug resistance is a major problem.
• Newer drugs used after primary medications become ineffective.
• Closely monitor for toxicities
• Risks of co-administration with NSAIDs
• Verify dosing schedule
Contraindicated in pregnancy
• Assess for patent IV with positive blood return
• Assess for appropriate site selection
• Central lines should be required for vesicant administration
Don't know?
, 3 of 40
Term
Methotrexate AE
Give this one a go later!
• Assess for patent IV with positive blood return
• Assess for appropriate site selection
• Central lines should be required for vesicant administration
Inhibits DNA synthesis, repair, and cellular replication. Unknown for RA, thought to
affect immune function
• Dependent on:
- Type, stage of cancer
- Drug efficacy in specific cancer
- Patient's age, health status
• Including liver, kidney function
• Dose must be carefully calculated to minimize toxicity
• Severe bone marrow suppression
• Thrombosis
• Pruritus and photosensitivity
• Stevens-Johnson syndrome and toxic epidermal necrolysis
• N/V/D
• Blood dyscrasias
• Elevated LFTs
• Renal failure
• Infections
