MLA SB A Qu estion B an k
Myeloproliferative Disorders
50 single best answer questions — Domain 6: Conditions, Body system: Blood and Lymph
Based on the GMC Medical Licensing Assessment (MLA) content map — applicable from September 2026
,BLOOD AND LY MPH Question 1 of 50
Myeloproliferative Disorders Chronic myeloid leukaemia
A 55-year-old man presents with fatigue, weight loss, night sweats, and marked splenomegaly. Full blood count shows a markedly raised
white cell count with a full spectrum of granulocyte maturation from myeloblasts to mature neutrophils. What is the most likely diagnosis?
A Essential thrombocythaemia
B Acute myeloid leukaemia
C Chronic lymphocytic leukaemia
D Myelofibrosis
E Chronic myeloid leukaemia
Select the single best answer.
,BLOOD AND LY MPH Question 1 of 50 — Answer
Myeloproliferative Disorders Chronic myeloid leukaemia
A 55-year-old man presents with fatigue, weight loss, night sweats, and marked splenomegaly. Full blood count shows a markedly raised white cell count with a full spectrum
of granulocyte maturation from myeloblasts to mature neutrophils. What is the most likely diagnosis?
A Essential thrombocythaemia
B Acute myeloid leukaemia
C Chronic lymphocytic leukaemia
D Myelofibrosis
E Chronic myeloid leukaemia ✓ Correct
EXPLANATION
CML presents with constitutional symptoms, marked splenomegaly, and a markedly raised white cell count showing a full spectrum of granulocyte maturation,
distinguishing it from the blast-predominant picture of acute leukaemia.
, BLOOD AND LY MPH Question 2 of 50
Myeloproliferative Disorders Chronic myeloid leukaemia
A 52-year-old man newly diagnosed with CML undergoes cytogenetic testing, which reveals the Philadelphia chromosome. Which
chromosomal translocation produces this abnormality?
A t(14;18)
B t(8;14)
C t(15;17)
D t(11;14)
E t(9;22)
Select the single best answer.
Myeloproliferative Disorders
50 single best answer questions — Domain 6: Conditions, Body system: Blood and Lymph
Based on the GMC Medical Licensing Assessment (MLA) content map — applicable from September 2026
,BLOOD AND LY MPH Question 1 of 50
Myeloproliferative Disorders Chronic myeloid leukaemia
A 55-year-old man presents with fatigue, weight loss, night sweats, and marked splenomegaly. Full blood count shows a markedly raised
white cell count with a full spectrum of granulocyte maturation from myeloblasts to mature neutrophils. What is the most likely diagnosis?
A Essential thrombocythaemia
B Acute myeloid leukaemia
C Chronic lymphocytic leukaemia
D Myelofibrosis
E Chronic myeloid leukaemia
Select the single best answer.
,BLOOD AND LY MPH Question 1 of 50 — Answer
Myeloproliferative Disorders Chronic myeloid leukaemia
A 55-year-old man presents with fatigue, weight loss, night sweats, and marked splenomegaly. Full blood count shows a markedly raised white cell count with a full spectrum
of granulocyte maturation from myeloblasts to mature neutrophils. What is the most likely diagnosis?
A Essential thrombocythaemia
B Acute myeloid leukaemia
C Chronic lymphocytic leukaemia
D Myelofibrosis
E Chronic myeloid leukaemia ✓ Correct
EXPLANATION
CML presents with constitutional symptoms, marked splenomegaly, and a markedly raised white cell count showing a full spectrum of granulocyte maturation,
distinguishing it from the blast-predominant picture of acute leukaemia.
, BLOOD AND LY MPH Question 2 of 50
Myeloproliferative Disorders Chronic myeloid leukaemia
A 52-year-old man newly diagnosed with CML undergoes cytogenetic testing, which reveals the Philadelphia chromosome. Which
chromosomal translocation produces this abnormality?
A t(14;18)
B t(8;14)
C t(15;17)
D t(11;14)
E t(9;22)
Select the single best answer.
