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generic name - Answers not capitalized, less expensive
brand name - Answers commercial name, capitalized
what are the different types of oral medications? - Answers liquid, tablet, capsule, powder
which form absorbs the fastest? - Answers liquid
which form absorbs the slowest? - Answers enteric coated tablet
what are the 3 ways a drug can be delivered parenterally? - Answers intravenously,
subcutaneously, intramuscularly
which parenteral drug is fastest? - Answers IV
pharmacokinetics - Answers movement of drugs from site of administration to various tissues
1st pass effect - Answers some of the drugs when passed though the liver may deactivate —>
reduces effect of drugs
bioavailability - Answers amount of oral drug after passing through the liver
parenteral drugs - Answers does not get affected by 1st pass effect because it goes directly to the
vein or tissue
what factors affect distribution to different parts of the body? - Answers -movement of drug by
circulatory system to intended site of action
-drugs enter the blood after they absorb through intestinal wall or alveoli in lungs or after
direct/indirect injection
-liver, heart, kidneys receive most of drugs because of their rich drug supply
-bones or areas with natural barrier (brain) won't receive as much of the drug
Metabolism (biotransformation) - Answers The biochemical alteration of a drug into an inactive
metabolite, a more soluble compound, a more potent active metabolite, or a less active metabolite
biotransformation - Answers when a drug is chemically altered during metabolism
Where does metabolism take place? - Answers liver
half life - Answers time it takes for a drug that enters the body to decrease in half
onset - Answers the time it takes for the drug to elicit a therapeutic response
peak - Answers The time it takes for a drug to reach its maximum therapeutic response
duration - Answers time the drug lasts without additional doses
peak level - Answers The maximum concentration of a drug in the body after administration,
usually measured in a blood sample for therapeutic drug monitoring.
trough level - Answers The lowest concentration of drug reached in the body after it falls from its
peak level, usually measured in a blood sample for therapeutic drug monitoring.
Why is peak & trough important? - Answers must maintain at a therapeutic level in the blood in
order to be effective
Pharmacodynamics - Answers Biochemical changes that occur in the body as a result of taking a
drug
adverse reactions - Answers a list of possible unpleasant or dangerous secondary effects other
than the desired effect
Therapeutic effect - Answers The desired or intended effect of a particular medication.
"off-label" - Answers the use of drugs for unapproved indication or in an unapproved age group,
dosage, or route of administration
most severe adverse reaction - Answers anaphylactic shock
clinical manifestations of anaphylactic shock - Answers swelling of eyes, mouth, face, and throat,
difficultly breathing, wheezing, rapid HR, extremely low BP, eventually cardiac arrest
drug tolerance - Answers body decreased response to a drug over a period of time or repeated use
cumulative effect - Answers When the body cannot completely metabolize and excrete one drug
dose before next dose is given
drug toxicity - Answers excessive doses result in negative physiologic effects (can be irreversible)
may lead to OVERDOSE
precautions - Answers benefits outweigh the risk
Contraindications - Answers drugs the provider should NOT prescribe because they have
potential to cause serious or life-threatening adverse effects
additive interaction - Answers medicines work together in a positive way (same effect x2)