ONS ONCC
Chemo Renewal II | Practice Questions, Answers
& Detailed Rationales | 2026/2027
Resource Features
➢ ONS/ONCC renewal-focused practice questions
➢ Answers for self-assessment
➢ Detailed rationales
➢ Oncology clinical scenarios
➢ Chemotherapy review
➢ Immunotherapy review
, ONS ONCC Chemo Renewal II | Practice
Questions, Answers & Detailed Rationales
| 2026/2027
Question 1
Which of the following is a unique side effect that occurs
with the agent oxaliplatin?
A) Myelosuppression
B) Cold sensory neuropathy
C) Mucositis
D) Alopecia
Answer: B) Cold sensory neuropathy
Rationale: Cold sensory neuropathy is a unique and characteristic
side effect of oxaliplatin. According to the prescribing
information, it is an acute, reversible, primarily peripheral sensory
neuropathy of early onset that occurs within hours or one to two
days of dosing. The symptoms are precipitated or exacerbated by
exposure to cold temperatures or cold objects and present as
transient paresthesia, dysesthesia, and hypoesthesia in the hands,
, feet, perioral area, or throat. While myelosuppression, mucositis,
and alopecia can occur with chemotherapy, they are not unique
to oxaliplatin.
Question 2
Which of the following are risk factors for developing
colorectal cancer? (Select all that apply)
A) Age over 50 years
B) Diet high in red and processed meats
C) Physical inactivity and obesity
D) Type 1 diabetes
E) Family history of colon cancer
F) African American or Ashkenazi Jewish descent
Answer: A, B, C, E, F
Rationale: Risk factors for colorectal cancer include increased age
(particularly after age 50), diet high in red and processed meats,
physical inactivity, obesity, family history of colon cancer or
inflammatory bowel disease, and certain racial/ethnic
backgrounds (African Americans and Ashkenazi Jews have the
highest incidence). Type 2 diabetes (not Type 1) is a risk factor for
colorectal cancer. Approximately 9 out of 10 people diagnosed
Chemo Renewal II | Practice Questions, Answers
& Detailed Rationales | 2026/2027
Resource Features
➢ ONS/ONCC renewal-focused practice questions
➢ Answers for self-assessment
➢ Detailed rationales
➢ Oncology clinical scenarios
➢ Chemotherapy review
➢ Immunotherapy review
, ONS ONCC Chemo Renewal II | Practice
Questions, Answers & Detailed Rationales
| 2026/2027
Question 1
Which of the following is a unique side effect that occurs
with the agent oxaliplatin?
A) Myelosuppression
B) Cold sensory neuropathy
C) Mucositis
D) Alopecia
Answer: B) Cold sensory neuropathy
Rationale: Cold sensory neuropathy is a unique and characteristic
side effect of oxaliplatin. According to the prescribing
information, it is an acute, reversible, primarily peripheral sensory
neuropathy of early onset that occurs within hours or one to two
days of dosing. The symptoms are precipitated or exacerbated by
exposure to cold temperatures or cold objects and present as
transient paresthesia, dysesthesia, and hypoesthesia in the hands,
, feet, perioral area, or throat. While myelosuppression, mucositis,
and alopecia can occur with chemotherapy, they are not unique
to oxaliplatin.
Question 2
Which of the following are risk factors for developing
colorectal cancer? (Select all that apply)
A) Age over 50 years
B) Diet high in red and processed meats
C) Physical inactivity and obesity
D) Type 1 diabetes
E) Family history of colon cancer
F) African American or Ashkenazi Jewish descent
Answer: A, B, C, E, F
Rationale: Risk factors for colorectal cancer include increased age
(particularly after age 50), diet high in red and processed meats,
physical inactivity, obesity, family history of colon cancer or
inflammatory bowel disease, and certain racial/ethnic
backgrounds (African Americans and Ashkenazi Jews have the
highest incidence). Type 2 diabetes (not Type 1) is a risk factor for
colorectal cancer. Approximately 9 out of 10 people diagnosed
