MDC III EXAM 1 REVIEW
350 REAL CONCEPTUAL & CLINICAL PRACTICE QUESTIONS WITH VERIFIED
RATIONALES
COMPLETE EXAM BANK • GRADED A+ PREPARATION
Course Title: Medical-Surgical Nursing Care III (MDC III)
Target Assessment: Exam 1 Comprehensive Mastery
Total Questions: 350 Multiple-Choice Questions
Renal & Urinary Disorders, Male & Female Reproductive
Primary Focus:
Systems, Breast & Oncologic Nursing
Question, Options A-D, Marked Correct Answer, Detailed
Format:
Rationale, Complete Master Key
Publication Date: 2026 Edition
MDC III EXAM 1: 350-QUESTION MASTER PRACTICE EXAM Page 1 of 122
, TABLE OF CONTENTS
Section 1: Renal & Urinary Tract Disorders (Questions 1 – 120) Page 2
• Acute & Chronic Pyelonephritis • Polycystic Kidney Disease (PKD) • Urolithiasis & Nephrolithiasis • Stage 1-5 CKD &
ESRD Management • Dialysis Protocols • Nephrotic Syndrome & Glomerulonephritis • AKI Management
Section 2: Male Reproductive & Urologic Oncology (Questions 121 – Page
230) Section 2
• Benign Prostatic Hyperplasia (BPH) & TURP • Prostate Cancer Screening, PSA & Biopsy • Modifiable Risk Factors &
Metastasis (Bone/Alkaline Phosphatase) • Testicular Cancer • Erectile Dysfunction & Prostatitis
Section 3: Female Reproductive Systems & Breast Oncology Page
(Questions 231 – 350) Section 3
• Breast Cancer Risk Factors & Dense Tissue • Diagnostic Confirmation (Biopsy) • Mammography Guidelines • HPV
Vaccination & Cervical Cancer Prevention • Ovarian & Endometrial Malignancies • Menopause Management
Master Answer Key (Questions 1 – 350 Summary Table) End
Section
MDC III EXAM 1: 350-QUESTION MASTER PRACTICE EXAM Page 2 of 122
, SECTION 1: RENAL & URINARY TRACT DISORDERS (Q1 – Q120)
QUESTION 1
The nurse educates a teenage client on the benefits of receiving the HPV vaccine as protection against which type
of cancer?
A. Ovarian cancer
B. Cervical cancer
C. Endometrial cancer
D. Breast cancer
🟦 CORRECT ANSWER: B. Cervical cancer
🔴 RATIONALE: Human Papillomavirus (HPV) is the primary causative agent associated with cervical dysplasia and
cervical cancer. Vaccination prior to HPV exposure provides robust primary prevention.
QUESTION 2
When educating a client, the nurse shares that which of the following is the most common cause of chronic
pyelonephritis?
A. Prolonged NSAID toxicity
B. Repeated or continued upper urinary tract infections
C. Untreated renal artery stenosis
D. Severe neurogenic bladder
🟦 CORRECT ANSWER: B. Repeated or continued upper urinary tract infections
🔴 RATIONALE: Chronic pyelonephritis usually results from recurrent or continuous upper urinary tract infections or
persistent vesicoureteral reflux, leading to progressive inflammation and scarring.
MDC III EXAM 1: 350-QUESTION MASTER PRACTICE EXAM Page 3 of 122
, QUESTION 3
Which of the following is considered a modifiable risk factor for the development of prostate cancer?
A. Advanced age
B. African American ethnicity
C. Family history
D. Diet
🟦 CORRECT ANSWER: D. Diet
🔴 RATIONALE: While age, race, and genetic inheritance are non-modifiable risk factors, diet (especially high intake of
saturated animal fats and red meats) is a modifiable risk factor.
QUESTION 4
Which of the following are common assessment findings for a client with acute pyelonephritis? (Select the most
accurate cluster)
A. Flank pain, fever, and burning with urinary frequency
B. Painless hematuria, peripheral edema, and weight gain
C. Hypertension, bounding pulse, and low back spasms
D. Nausea, skin jaundice, and dark black stool
🟦 CORRECT ANSWER: A. Flank pain, fever, and burning with urinary frequency
🔴 RATIONALE: Acute pyelonephritis presents with systemic infection manifestations (fever, chills) combined with upper/
lower urinary symptoms including flank pain/CVA tenderness, dysuria (burning), and urinary frequency.
QUESTION 5
A nurse is caring for a client diagnosed with polycystic kidney disease (PKD). The nurse anticipates the following
interventions or treatment options EXCEPT which one?
A. Blood transfusion
B. Antihypertensive administration
C. Pain management
D. Fluid intake monitoring
🟦 CORRECT ANSWER: A. Blood transfusion
🔴 RATIONALE: Blood transfusions are avoided when possible in PKD clients because transfusions introduce foreign HLA
antigens, increasing sensitization and making future kidney transplantation significantly more difficult to match.
MDC III EXAM 1: 350-QUESTION MASTER PRACTICE EXAM Page 4 of 122
350 REAL CONCEPTUAL & CLINICAL PRACTICE QUESTIONS WITH VERIFIED
RATIONALES
COMPLETE EXAM BANK • GRADED A+ PREPARATION
Course Title: Medical-Surgical Nursing Care III (MDC III)
Target Assessment: Exam 1 Comprehensive Mastery
Total Questions: 350 Multiple-Choice Questions
Renal & Urinary Disorders, Male & Female Reproductive
Primary Focus:
Systems, Breast & Oncologic Nursing
Question, Options A-D, Marked Correct Answer, Detailed
Format:
Rationale, Complete Master Key
Publication Date: 2026 Edition
MDC III EXAM 1: 350-QUESTION MASTER PRACTICE EXAM Page 1 of 122
, TABLE OF CONTENTS
Section 1: Renal & Urinary Tract Disorders (Questions 1 – 120) Page 2
• Acute & Chronic Pyelonephritis • Polycystic Kidney Disease (PKD) • Urolithiasis & Nephrolithiasis • Stage 1-5 CKD &
ESRD Management • Dialysis Protocols • Nephrotic Syndrome & Glomerulonephritis • AKI Management
Section 2: Male Reproductive & Urologic Oncology (Questions 121 – Page
230) Section 2
• Benign Prostatic Hyperplasia (BPH) & TURP • Prostate Cancer Screening, PSA & Biopsy • Modifiable Risk Factors &
Metastasis (Bone/Alkaline Phosphatase) • Testicular Cancer • Erectile Dysfunction & Prostatitis
Section 3: Female Reproductive Systems & Breast Oncology Page
(Questions 231 – 350) Section 3
• Breast Cancer Risk Factors & Dense Tissue • Diagnostic Confirmation (Biopsy) • Mammography Guidelines • HPV
Vaccination & Cervical Cancer Prevention • Ovarian & Endometrial Malignancies • Menopause Management
Master Answer Key (Questions 1 – 350 Summary Table) End
Section
MDC III EXAM 1: 350-QUESTION MASTER PRACTICE EXAM Page 2 of 122
, SECTION 1: RENAL & URINARY TRACT DISORDERS (Q1 – Q120)
QUESTION 1
The nurse educates a teenage client on the benefits of receiving the HPV vaccine as protection against which type
of cancer?
A. Ovarian cancer
B. Cervical cancer
C. Endometrial cancer
D. Breast cancer
🟦 CORRECT ANSWER: B. Cervical cancer
🔴 RATIONALE: Human Papillomavirus (HPV) is the primary causative agent associated with cervical dysplasia and
cervical cancer. Vaccination prior to HPV exposure provides robust primary prevention.
QUESTION 2
When educating a client, the nurse shares that which of the following is the most common cause of chronic
pyelonephritis?
A. Prolonged NSAID toxicity
B. Repeated or continued upper urinary tract infections
C. Untreated renal artery stenosis
D. Severe neurogenic bladder
🟦 CORRECT ANSWER: B. Repeated or continued upper urinary tract infections
🔴 RATIONALE: Chronic pyelonephritis usually results from recurrent or continuous upper urinary tract infections or
persistent vesicoureteral reflux, leading to progressive inflammation and scarring.
MDC III EXAM 1: 350-QUESTION MASTER PRACTICE EXAM Page 3 of 122
, QUESTION 3
Which of the following is considered a modifiable risk factor for the development of prostate cancer?
A. Advanced age
B. African American ethnicity
C. Family history
D. Diet
🟦 CORRECT ANSWER: D. Diet
🔴 RATIONALE: While age, race, and genetic inheritance are non-modifiable risk factors, diet (especially high intake of
saturated animal fats and red meats) is a modifiable risk factor.
QUESTION 4
Which of the following are common assessment findings for a client with acute pyelonephritis? (Select the most
accurate cluster)
A. Flank pain, fever, and burning with urinary frequency
B. Painless hematuria, peripheral edema, and weight gain
C. Hypertension, bounding pulse, and low back spasms
D. Nausea, skin jaundice, and dark black stool
🟦 CORRECT ANSWER: A. Flank pain, fever, and burning with urinary frequency
🔴 RATIONALE: Acute pyelonephritis presents with systemic infection manifestations (fever, chills) combined with upper/
lower urinary symptoms including flank pain/CVA tenderness, dysuria (burning), and urinary frequency.
QUESTION 5
A nurse is caring for a client diagnosed with polycystic kidney disease (PKD). The nurse anticipates the following
interventions or treatment options EXCEPT which one?
A. Blood transfusion
B. Antihypertensive administration
C. Pain management
D. Fluid intake monitoring
🟦 CORRECT ANSWER: A. Blood transfusion
🔴 RATIONALE: Blood transfusions are avoided when possible in PKD clients because transfusions introduce foreign HLA
antigens, increasing sensitization and making future kidney transplantation significantly more difficult to match.
MDC III EXAM 1: 350-QUESTION MASTER PRACTICE EXAM Page 4 of 122
