Page 1 of 71
MARIA LEIK AGNP EXAM REVIEW – 2026/2027 COMPLETE
(150) CURRENT TESTING QUESTIONS AND CORRECT
ANSWERS WITH DETAILED RATIONALES.
LEIK AGNP
Prepare effectively for the Maria Leik AGNP Exam Review with this focused study
resource. It supports review of adult-gerontology primary care, health assessment,
common acute and chronic conditions, diagnosis, pharmacology, treatment planning,
and preventive care. Use the material to reinforce your clinical knowledge, review
high-yield topics, and identify areas that may require additional study. This resource is
suited for AGNP students, nurse practitioner learners, and candidates preparing for
adult-gerontology nurse practitioner examinations.
MULTIPLE CHOICE.
SECTION 1: HEALTH PROMOTION, SCREENING, & DISEASE PREVENTION
(Questions 1–25)
1. A 55-year-old African American male with a 30-pack-year smoking
history presents for a routine health maintenance visit. According to
USPSTF guidelines, which screening is MOST appropriate for this patient?
• A. Annual chest X-ray
• B. Low-dose CT scan annually for lung cancer
• C. Sputum cytology every 6 months
• D. PET scan every 2 years
Correct Answer: B
Rationale: The USPSTF recommends annual lung cancer screening with
low-dose CT for adults aged 50–80 years with a 20-pack-year smoking
history who currently smoke or have quit within the past 15 years. This
patient meets these criteria. Chest X-ray and sputum cytology are not
recommended for screening.
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2. A 68-year-old female with no prior colon cancer screening asks about
colon cancer screening options. Which of the following is an appropriate
recommendation?
• A. Colonoscopy every 5 years
• B. Fecal immunochemical test (FIT) annually
• C. Flexible sigmoidoscopy every 2 years
• D. CT colonography every 10 years
Correct Answer: B
Rationale: For average-risk adults aged 45–75, the USPSTF recommends
screening for colorectal cancer. Options include annual FIT, colonoscopy
every 10 years, or flexible sigmoidoscopy every 5 years. FIT is a
reasonable option for patients who prefer non-invasive testing.
3. A 65-year-old female with a history of hypertension and hyperlipidemia
presents for her annual wellness visit. She has no family history of breast
cancer. When should she have her next screening mammogram?
• A. Annually until age 70
• B. Every 2 years until age 75
• C. Every 3 years until age 80
• D. Discontinue screening at age 65
Correct Answer: B
Rationale: The USPSTF recommends biennial screening mammography
for women aged 50–74 years. The decision to continue screening after age
75 should be individualized based on life expectancy and comorbidities.
This patient has no high-risk factors, so biennial screening is appropriate.
4. A 72-year-old male with a 45-pack-year smoking history and
hypertension presents for a physical. He has no history of abdominal
aortic aneurysm (AAA). Which screening is recommended?
, Page 3 of 71
• A. No screening is indicated
• B. One-time abdominal ultrasound
• C. Annual abdominal ultrasound
• D. CT angiography of the abdomen
Correct Answer: B
Rationale: The USPSTF recommends a one-time abdominal ultrasound
screening for AAA in men aged 65–75 who have ever smoked. This patient
meets both criteria. Women with a smoking history do not have sufficient
evidence for routine screening.
5. A 58-year-old female with obesity (BMI 32) and a family history of type 2
diabetes presents for preventive care. Which screening test is MOST
appropriate?
• A. Fasting plasma glucose every 3 years
• B. Hemoglobin A1c annually
• C. Oral glucose tolerance test
• D. Random glucose check
Correct Answer: A
Rationale: The USPSTF recommends screening for prediabetes and type 2
diabetes in adults aged 35–70 with overweight or obesity. Screening can
be done with fasting plasma glucose, hemoglobin A1c, or oral glucose
tolerance test, repeated every 3 years if normal. Fasting glucose is a
standard and accessible option.
6. A 67-year-old male with a history of hypertension and hyperlipidemia
asks about aspirin for primary prevention of cardiovascular disease. He
has no history of cardiovascular events. What is the MOST appropriate
recommendation?
• A. Start low-dose aspirin 81 mg daily
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• B. Start aspirin 325 mg daily
• C. Do not start aspirin for primary prevention
• D. Start aspirin only if he develops chest pain
Correct Answer: C
Rationale: Current guidelines recommend against initiating aspirin for
primary prevention of cardiovascular disease in adults over 60 years of
age due to increased bleeding risk. For adults 40–59 with elevated
cardiovascular risk, the decision should be individualized.
7. A 62-year-old female with no comorbidities asks about the shingles
(herpes zoster) vaccine. Which vaccine is recommended?
• A. Zoster vaccine live (Zostavax)
• B. Recombinant zoster vaccine (Shingrix) two-dose series
• C. No vaccine is needed at this age
• D. Single dose of recombinant zoster vaccine
Correct Answer: B
Rationale: The CDC recommends the recombinant zoster vaccine
(Shingrix) for adults aged 50 years and older, given as a two-dose series
(2–6 months apart). It is preferred over the live vaccine (Zostavax) due to
higher efficacy.
8. A 66-year-old male with a history of COPD and hypertension presents
for a physical. He has never received a pneumococcal vaccine. Which
vaccination is indicated?
• A. PCV15 alone
• B. PPSV23 alone
• C. PCV15 followed by PPSV23 one year later
• D. PCV20 alone
MARIA LEIK AGNP EXAM REVIEW – 2026/2027 COMPLETE
(150) CURRENT TESTING QUESTIONS AND CORRECT
ANSWERS WITH DETAILED RATIONALES.
LEIK AGNP
Prepare effectively for the Maria Leik AGNP Exam Review with this focused study
resource. It supports review of adult-gerontology primary care, health assessment,
common acute and chronic conditions, diagnosis, pharmacology, treatment planning,
and preventive care. Use the material to reinforce your clinical knowledge, review
high-yield topics, and identify areas that may require additional study. This resource is
suited for AGNP students, nurse practitioner learners, and candidates preparing for
adult-gerontology nurse practitioner examinations.
MULTIPLE CHOICE.
SECTION 1: HEALTH PROMOTION, SCREENING, & DISEASE PREVENTION
(Questions 1–25)
1. A 55-year-old African American male with a 30-pack-year smoking
history presents for a routine health maintenance visit. According to
USPSTF guidelines, which screening is MOST appropriate for this patient?
• A. Annual chest X-ray
• B. Low-dose CT scan annually for lung cancer
• C. Sputum cytology every 6 months
• D. PET scan every 2 years
Correct Answer: B
Rationale: The USPSTF recommends annual lung cancer screening with
low-dose CT for adults aged 50–80 years with a 20-pack-year smoking
history who currently smoke or have quit within the past 15 years. This
patient meets these criteria. Chest X-ray and sputum cytology are not
recommended for screening.
, Page 2 of 71
2. A 68-year-old female with no prior colon cancer screening asks about
colon cancer screening options. Which of the following is an appropriate
recommendation?
• A. Colonoscopy every 5 years
• B. Fecal immunochemical test (FIT) annually
• C. Flexible sigmoidoscopy every 2 years
• D. CT colonography every 10 years
Correct Answer: B
Rationale: For average-risk adults aged 45–75, the USPSTF recommends
screening for colorectal cancer. Options include annual FIT, colonoscopy
every 10 years, or flexible sigmoidoscopy every 5 years. FIT is a
reasonable option for patients who prefer non-invasive testing.
3. A 65-year-old female with a history of hypertension and hyperlipidemia
presents for her annual wellness visit. She has no family history of breast
cancer. When should she have her next screening mammogram?
• A. Annually until age 70
• B. Every 2 years until age 75
• C. Every 3 years until age 80
• D. Discontinue screening at age 65
Correct Answer: B
Rationale: The USPSTF recommends biennial screening mammography
for women aged 50–74 years. The decision to continue screening after age
75 should be individualized based on life expectancy and comorbidities.
This patient has no high-risk factors, so biennial screening is appropriate.
4. A 72-year-old male with a 45-pack-year smoking history and
hypertension presents for a physical. He has no history of abdominal
aortic aneurysm (AAA). Which screening is recommended?
, Page 3 of 71
• A. No screening is indicated
• B. One-time abdominal ultrasound
• C. Annual abdominal ultrasound
• D. CT angiography of the abdomen
Correct Answer: B
Rationale: The USPSTF recommends a one-time abdominal ultrasound
screening for AAA in men aged 65–75 who have ever smoked. This patient
meets both criteria. Women with a smoking history do not have sufficient
evidence for routine screening.
5. A 58-year-old female with obesity (BMI 32) and a family history of type 2
diabetes presents for preventive care. Which screening test is MOST
appropriate?
• A. Fasting plasma glucose every 3 years
• B. Hemoglobin A1c annually
• C. Oral glucose tolerance test
• D. Random glucose check
Correct Answer: A
Rationale: The USPSTF recommends screening for prediabetes and type 2
diabetes in adults aged 35–70 with overweight or obesity. Screening can
be done with fasting plasma glucose, hemoglobin A1c, or oral glucose
tolerance test, repeated every 3 years if normal. Fasting glucose is a
standard and accessible option.
6. A 67-year-old male with a history of hypertension and hyperlipidemia
asks about aspirin for primary prevention of cardiovascular disease. He
has no history of cardiovascular events. What is the MOST appropriate
recommendation?
• A. Start low-dose aspirin 81 mg daily
, Page 4 of 71
• B. Start aspirin 325 mg daily
• C. Do not start aspirin for primary prevention
• D. Start aspirin only if he develops chest pain
Correct Answer: C
Rationale: Current guidelines recommend against initiating aspirin for
primary prevention of cardiovascular disease in adults over 60 years of
age due to increased bleeding risk. For adults 40–59 with elevated
cardiovascular risk, the decision should be individualized.
7. A 62-year-old female with no comorbidities asks about the shingles
(herpes zoster) vaccine. Which vaccine is recommended?
• A. Zoster vaccine live (Zostavax)
• B. Recombinant zoster vaccine (Shingrix) two-dose series
• C. No vaccine is needed at this age
• D. Single dose of recombinant zoster vaccine
Correct Answer: B
Rationale: The CDC recommends the recombinant zoster vaccine
(Shingrix) for adults aged 50 years and older, given as a two-dose series
(2–6 months apart). It is preferred over the live vaccine (Zostavax) due to
higher efficacy.
8. A 66-year-old male with a history of COPD and hypertension presents
for a physical. He has never received a pneumococcal vaccine. Which
vaccination is indicated?
• A. PCV15 alone
• B. PPSV23 alone
• C. PCV15 followed by PPSV23 one year later
• D. PCV20 alone
