COMSAE 115 EXAM 2026/2027
500 ACTUAL QUESTIONS & ANSWERS WITH RATIONALES
2026-2027
500 Questions
100% VERIFIED
Introduction
The COMSAE 115 Exam 2026/2027 is a comprehensive assessment designed to evaluate
osteopathic medical students' knowledge across foundational biomedical sciences,
osteopathic principles and manipulative treatment, clinical medicine and patient care,
pharmacology and therapeutics, public health and preventive medicine, diagnostic
interpretation, and professional ethics and legal standards. This examination assesses
readiness for clinical execution and professional competence in osteopathic medical
education. The following 500 questions represent the breadth and depth of knowledge
required for successful completion of this examination.
1. Which organelle produces ATP?
• A. Mitochondria
• B. Golgi
• C. ER
• D. Lysosome
Rationale: Mitochondria produce ATP via oxidative phosphorylation.
2. Rough ER function?
• A. Lipid synthesis
• B. Protein synthesis
• C. Detox
• D. Ca storage
Rationale: Rough ER synthesizes and modifies proteins.
3. DNA replication phase?
,• A. G1
• B. S
• C. G2
• D. M
Rationale: S phase is when DNA replicates.
4. Na/K pump action?
• A. Na in/K out
• B. Na out/K in
• C. Both in
• D. Both out
Rationale: Pumps 3 Na out, 2 K in per ATP.
5. mRNA function?
• A. Carry amino acids
• B. Form ribosomes
• C. Carry genetic code
• D. Splice RNA
Rationale: mRNA carries genetic code to ribosomes.
6. Parasympathetic NT?
• A. Norepinephrine
• B. Epinephrine
• C. Acetylcholine
• D. Dopamine
Rationale: ACh is primary parasympathetic NT.
7. Posterior pituitary hormones?
• A. GH/TSH
• B. ACTH/FSH
• C. ADH/oxytocin
• D. LH/prolactin
,Rationale: Posterior pituitary stores ADH and oxytocin.
8. Loop of Henle function?
• A. Filtration
• B. Concentration
• C. Secretion
• D. Glucose reabsorption
Rationale: Loop creates medullary gradient for concentration.
9. Vaccination immunity type?
• A. Natural active
• B. Natural passive
• C. Artificial active
• D. Artificial passive
Rationale: Vaccines provide artificial active immunity.
10. Frank-Starling law?
• A. HR/BP
• B. Preload/SV
• C. Contractility/afterload
• D. HR/contractility
Rationale: Increased preload increases stroke volume.
11. GI enzyme in mouth?
• A. Pepsin
• B. Amylase
• C. Trypsin
• D. Lipase
Rationale: Salivary amylase begins starch digestion.
12. Spleen function?
, • A. Bile production
• B. Blood filtration
• C. Insulin production
• D. Hormone storage
Rationale: Spleen filters blood and removes old RBCs.
13. Fatigue-resistant fibers?
• A. Type I
• B. Type IIa
• C. Type IIx
• D. Type IIb
Rationale: Type I fibers are slow oxidative, fatigue-resistant.
14. Surfactant function?
• A. Increase tension
• B. Decrease tension
• C. Gas exchange
• D. Immunity
Rationale: Surfactant decreases surface tension, prevents collapse.
15. Bone resorption hormone?
• A. Calcitonin
• B. PTH
• C. Estrogen
• D. Vitamin D
Rationale: PTH stimulates osteoclasts and bone resorption.
16. Gas exchange site?
• A. Trachea
• B. Bronchi
• C. Alveoli
• D. Bronchioles
500 ACTUAL QUESTIONS & ANSWERS WITH RATIONALES
2026-2027
500 Questions
100% VERIFIED
Introduction
The COMSAE 115 Exam 2026/2027 is a comprehensive assessment designed to evaluate
osteopathic medical students' knowledge across foundational biomedical sciences,
osteopathic principles and manipulative treatment, clinical medicine and patient care,
pharmacology and therapeutics, public health and preventive medicine, diagnostic
interpretation, and professional ethics and legal standards. This examination assesses
readiness for clinical execution and professional competence in osteopathic medical
education. The following 500 questions represent the breadth and depth of knowledge
required for successful completion of this examination.
1. Which organelle produces ATP?
• A. Mitochondria
• B. Golgi
• C. ER
• D. Lysosome
Rationale: Mitochondria produce ATP via oxidative phosphorylation.
2. Rough ER function?
• A. Lipid synthesis
• B. Protein synthesis
• C. Detox
• D. Ca storage
Rationale: Rough ER synthesizes and modifies proteins.
3. DNA replication phase?
,• A. G1
• B. S
• C. G2
• D. M
Rationale: S phase is when DNA replicates.
4. Na/K pump action?
• A. Na in/K out
• B. Na out/K in
• C. Both in
• D. Both out
Rationale: Pumps 3 Na out, 2 K in per ATP.
5. mRNA function?
• A. Carry amino acids
• B. Form ribosomes
• C. Carry genetic code
• D. Splice RNA
Rationale: mRNA carries genetic code to ribosomes.
6. Parasympathetic NT?
• A. Norepinephrine
• B. Epinephrine
• C. Acetylcholine
• D. Dopamine
Rationale: ACh is primary parasympathetic NT.
7. Posterior pituitary hormones?
• A. GH/TSH
• B. ACTH/FSH
• C. ADH/oxytocin
• D. LH/prolactin
,Rationale: Posterior pituitary stores ADH and oxytocin.
8. Loop of Henle function?
• A. Filtration
• B. Concentration
• C. Secretion
• D. Glucose reabsorption
Rationale: Loop creates medullary gradient for concentration.
9. Vaccination immunity type?
• A. Natural active
• B. Natural passive
• C. Artificial active
• D. Artificial passive
Rationale: Vaccines provide artificial active immunity.
10. Frank-Starling law?
• A. HR/BP
• B. Preload/SV
• C. Contractility/afterload
• D. HR/contractility
Rationale: Increased preload increases stroke volume.
11. GI enzyme in mouth?
• A. Pepsin
• B. Amylase
• C. Trypsin
• D. Lipase
Rationale: Salivary amylase begins starch digestion.
12. Spleen function?
, • A. Bile production
• B. Blood filtration
• C. Insulin production
• D. Hormone storage
Rationale: Spleen filters blood and removes old RBCs.
13. Fatigue-resistant fibers?
• A. Type I
• B. Type IIa
• C. Type IIx
• D. Type IIb
Rationale: Type I fibers are slow oxidative, fatigue-resistant.
14. Surfactant function?
• A. Increase tension
• B. Decrease tension
• C. Gas exchange
• D. Immunity
Rationale: Surfactant decreases surface tension, prevents collapse.
15. Bone resorption hormone?
• A. Calcitonin
• B. PTH
• C. Estrogen
• D. Vitamin D
Rationale: PTH stimulates osteoclasts and bone resorption.
16. Gas exchange site?
• A. Trachea
• B. Bronchi
• C. Alveoli
• D. Bronchioles
