CPJE BRAND GENERIC EXAM SCRIPT
VERIFIED QUESTIONS WITH ACCURATE
ANSWERS
●● N-acetylcysteine
Answer: NAC/Acetadote/Cetylev
PO(effervescent,soln) and IV(D5W/SWFI/1/2NS)
APAP Antidote/Mucolytic Agent
MOA: Hematoprotective/glutathione substitute. Mucolytic action by
opening disulfide bonds
FDA: 72-hr, 18 dose PO and 21-hr, 3 dose IV regimens
SE: Autoimmune, anaphylaxis, urticaria/pruritis, N/V/GI
Stor/Stab: IV-room temp, use w/n 24hrs-may turn light pink/purple; effer
soln use w/n 2 hours of dissolution
●● baclofen
Answer: Lioresal
PO, Intrathecal
Muscle relaxant/antispasmotic
MOA: Inhibits transmission of reflexes at the spinal cord
,Dose: Initial: 5mg TID; usual 40-80mg 3-4x/day
SE: Hypotonia, drowsiness, N/V, HoTN
●● carisoprodol
Answer: Soma
PO - Skeletal muscle relaxant
MOA: Not clear - central depressant actions
Dose: 250-350mg TID and qHS for max of 2-3wks
*Long-term use requires a slow taper
SE: Drowsiness, dizziness, HA
●● cyclobenzaprine
Answer: Flexeril
PO - Skeletal muscle relaxant
MOA: Centrally acting, related to TCAs, reduces tonic somatic motor
activity
Dose: Cap-15mg daily; Tab-5mg TID; max 2-3wks
SE: Drowsiness, dizziness, xerostomia, HA - monitor for s/sx of
serotonin syndrome
●● metaxalone
,Answer: Skelaxin/Metaxall
PO - skeletal muscle relaxant
MOA: General depression of nervous system
Dose: 800mg 3-4x/day
SE: Dizziness, drowsiness, HA, irritability, GI, rash
●● methocarbamol
Answer: Robaxin
PO, IV(diluted/undiluted D5W/NS), IM(glutes)
Muscle spasms/tetanus
MOA: General CNS depression
Dose: PO 1.5g 4x/day; IM/IV 1gm q8hr x3days
SE: HoTN, confusion, dizziness, rash, GI
●● tizanidine
Answer: Zanaflex
PO(Cap-can sprinkle on food)
MOA: Alpha2-adrenergic agonist
Dose: Initial 2mg TID; max 36mg; gradual taper off
, *CrCl<25-use with caution
SE: HoTN, drowsiness, xerostomia, weakness; Monitor live function
●● celecoxib
Answer: Celebrex
PO (can be sprinkled on food)
MOA: COX-2 selective NSAID at higher doses
Dose: 100mg BID or 200mg daily. Higher for gout
*Use not rec in severe renal/hepatic disease
SE: GI, increase LFTs, URTIs
*NSAIDs increase risk of serious CV events
●● acetylsalicylic acid
Answer: Aspirin/Ecotren
●● diclofenac
Answer: Voltaren DR/Voltaren ER
PO (DR, ER, IR, powder), PR, IV(bolus)
MOA: COX-1 and -2 inhibitor
Dose: 50mg TID, 100mg daily, 37.5mg IV q6hr
VERIFIED QUESTIONS WITH ACCURATE
ANSWERS
●● N-acetylcysteine
Answer: NAC/Acetadote/Cetylev
PO(effervescent,soln) and IV(D5W/SWFI/1/2NS)
APAP Antidote/Mucolytic Agent
MOA: Hematoprotective/glutathione substitute. Mucolytic action by
opening disulfide bonds
FDA: 72-hr, 18 dose PO and 21-hr, 3 dose IV regimens
SE: Autoimmune, anaphylaxis, urticaria/pruritis, N/V/GI
Stor/Stab: IV-room temp, use w/n 24hrs-may turn light pink/purple; effer
soln use w/n 2 hours of dissolution
●● baclofen
Answer: Lioresal
PO, Intrathecal
Muscle relaxant/antispasmotic
MOA: Inhibits transmission of reflexes at the spinal cord
,Dose: Initial: 5mg TID; usual 40-80mg 3-4x/day
SE: Hypotonia, drowsiness, N/V, HoTN
●● carisoprodol
Answer: Soma
PO - Skeletal muscle relaxant
MOA: Not clear - central depressant actions
Dose: 250-350mg TID and qHS for max of 2-3wks
*Long-term use requires a slow taper
SE: Drowsiness, dizziness, HA
●● cyclobenzaprine
Answer: Flexeril
PO - Skeletal muscle relaxant
MOA: Centrally acting, related to TCAs, reduces tonic somatic motor
activity
Dose: Cap-15mg daily; Tab-5mg TID; max 2-3wks
SE: Drowsiness, dizziness, xerostomia, HA - monitor for s/sx of
serotonin syndrome
●● metaxalone
,Answer: Skelaxin/Metaxall
PO - skeletal muscle relaxant
MOA: General depression of nervous system
Dose: 800mg 3-4x/day
SE: Dizziness, drowsiness, HA, irritability, GI, rash
●● methocarbamol
Answer: Robaxin
PO, IV(diluted/undiluted D5W/NS), IM(glutes)
Muscle spasms/tetanus
MOA: General CNS depression
Dose: PO 1.5g 4x/day; IM/IV 1gm q8hr x3days
SE: HoTN, confusion, dizziness, rash, GI
●● tizanidine
Answer: Zanaflex
PO(Cap-can sprinkle on food)
MOA: Alpha2-adrenergic agonist
Dose: Initial 2mg TID; max 36mg; gradual taper off
, *CrCl<25-use with caution
SE: HoTN, drowsiness, xerostomia, weakness; Monitor live function
●● celecoxib
Answer: Celebrex
PO (can be sprinkled on food)
MOA: COX-2 selective NSAID at higher doses
Dose: 100mg BID or 200mg daily. Higher for gout
*Use not rec in severe renal/hepatic disease
SE: GI, increase LFTs, URTIs
*NSAIDs increase risk of serious CV events
●● acetylsalicylic acid
Answer: Aspirin/Ecotren
●● diclofenac
Answer: Voltaren DR/Voltaren ER
PO (DR, ER, IR, powder), PR, IV(bolus)
MOA: COX-1 and -2 inhibitor
Dose: 50mg TID, 100mg daily, 37.5mg IV q6hr
