CPHON FINAL PAPER 2026 DETAILED
QUESTIONS AND ACCURATE ANSWERS
PREMIUM QUALITY
◉ multimodal
Answer: with other agents
◉ neoadjuvant
Answer: preop to decrease tumor burden
◉ adjuvant
Answer: residual disease treated
◉ santuary
Answer: crosses blood brain barrier
◉ Interphase
Answer: -G1: growth of cellular components not chromosomes
-S: DNA synthesis
-G2: growth and prepare for mitosis/checks for errors and repairs
,◉ mitosis
Answer: cell division
◉ G0
Answer: inactive/resting
◉ anti-metabolites
Answer: interfere with DNA and RNA synthesis-S phase
◉ anti-metabolite examples:
Answer: -gemciabine
-cytarabine
-methotrexate
-6-MP
-fludarabine
-hydroxyurea
◉ plant derivatives
Answer: -affect microtubule production-G0, G1, S
-damages in all phases by stopping enzymes from making proteins
needed for reproduction
, ◉ plant derivative examples:
Answer: -vinca alkaloids
-epipodophryllotoxin
-taxans
-camptothecin derviatives
◉ Vinca Alkaloids
Answer: -Work in M phase
Includes:
vincristine, vinblastine, videsine, vindelbine
◉ Vinca alkaloid S/S
Answer: neuropathy, constipation, jaw pain
◉ Vinca alkaloids cannot be given
Answer: intrathecally
◉ epipodophyllotoxins
Answer: -S and G2 phases
-indices single and double strand breaks in DNA synthesis
Includes:
QUESTIONS AND ACCURATE ANSWERS
PREMIUM QUALITY
◉ multimodal
Answer: with other agents
◉ neoadjuvant
Answer: preop to decrease tumor burden
◉ adjuvant
Answer: residual disease treated
◉ santuary
Answer: crosses blood brain barrier
◉ Interphase
Answer: -G1: growth of cellular components not chromosomes
-S: DNA synthesis
-G2: growth and prepare for mitosis/checks for errors and repairs
,◉ mitosis
Answer: cell division
◉ G0
Answer: inactive/resting
◉ anti-metabolites
Answer: interfere with DNA and RNA synthesis-S phase
◉ anti-metabolite examples:
Answer: -gemciabine
-cytarabine
-methotrexate
-6-MP
-fludarabine
-hydroxyurea
◉ plant derivatives
Answer: -affect microtubule production-G0, G1, S
-damages in all phases by stopping enzymes from making proteins
needed for reproduction
, ◉ plant derivative examples:
Answer: -vinca alkaloids
-epipodophryllotoxin
-taxans
-camptothecin derviatives
◉ Vinca Alkaloids
Answer: -Work in M phase
Includes:
vincristine, vinblastine, videsine, vindelbine
◉ Vinca alkaloid S/S
Answer: neuropathy, constipation, jaw pain
◉ Vinca alkaloids cannot be given
Answer: intrathecally
◉ epipodophyllotoxins
Answer: -S and G2 phases
-indices single and double strand breaks in DNA synthesis
Includes: