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COMSAE Comprehensive Exam Test Bank 2026/2027: Complete Practice Questions

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Comprehensive COMSAE exam bank featuring 700+ questions with verified answers. Covers OMT, pharmacology, internal medicine, pediatrics, surgery, OB/GYN, psychiatry, and emergency medicine. Essential resource for osteopathic medical students preparing for COMLEX.

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ALL THE COMSAE EXAM TEST BANK
EXAM WITH COMPLETE QUESTIONS AND
CORRECT VERIFIED ANSWERS ALREADY
GRADED A+


Antibodies in hashimotos attacks - ✔✔✔ Correct Answer > thyroid peroxidase or
antithyroglobulin
D


Enlarged non tender thyroid
O
N


2 factors that influence starling curve - ✔✔✔ Correct Answer > x axis- preload
O


(EDV) Y axis- stroke volume or CO
T
C


Treatment for fibromyalgia - ✔✔✔ Correct Answer > TCA, snris anticonvulsants
O
PY


What blocks NE reuptake? - ✔✔✔ Correct Answer > TCA or snris


Possible complication of pagets bone disease - ✔✔✔ Correct Answer > osteocarcoma


What does Hct tell you? - ✔✔✔ Correct Answer > ratio of volume of rbcs compared to
total blood volume


Probenecid - ✔✔✔ Correct Answer > inhibits reabsoprtion of uric acid in PCT
- also inhibits secretion of PCN

,- can ppt uric acid calculi


2 causes of SCID - ✔✔✔ Correct Answer > ADA deficiency
(adenosine deaminase required for degradation of adenosim and deoxyadenosine
- in ADA deficiency, high levels of datp --> toxicity in lymphocytes --> SCID


Hypoplastic thymus


Lithiums effects on urination - ✔✔✔ Correct Answer > inhibits vasopression/ADH -->
D


increased urinary frequency
O
N


Infertility drug that can result in multiple fetuses - ✔✔✔ Correct Answer > clomiphene
O


(clones- multiple babies)
T
C


Antagonist at estrogen R in hypothalamus (thus inhibits normal negative feedback)
O
PY


Upregulates LH and FSH release from pituitary --> ovulation


Used to treat PCOS but can cause ovarian enlargement, multiple fetuses


AFP levels in down syndrome - ✔✔✔ Correct Answer > low


GI malformation A/W down syndrome - ✔✔✔ Correct Answer > Hirschprungs-
congenital aganglionic megacolon

,Defective relaxation and peristalsis of rectum and distal sigmoid colon


Failure to pass meconium, empty rectal vault, megacolon


Myasthenia gravis associations - ✔✔✔ Correct Answer > thymoma, thymic
hyperplasia


Ptosis, diplopia, can affect chewing, swallowing, speaking, shoulders, respiration


Tx for tinea - ✔✔✔ Correct Answer > azoles
D
O
N


Beta blockers for asthma - ✔✔✔ Correct Answer > none- even beta 1s can be
O


nonselective at higher doses
T


What kind of teratogenic effects are seen w ACE/arbs - ✔✔✔ Correct Answer > fetal
C


renal agenesis
O
PY



Which type of pneumothorax causes tracheal deviation to the contra side? - ✔✔✔
Correct Answer > tension



Spencer's technique - ✔✔✔ Correct Answer > 1. Extend shoulder
2. Flexion of shoulder with elbow extension
3. Circumduction w/ compression
4. Circumduction w/ extraction
5. Abduct shoulder

, 6. Internal and external rotation
7. Pump shoulder


Intracerebral hemorrhage adjacent to a lesion that contains a tangle of numerous
tortuous vessels - ✔✔✔ Correct Answer > AVM arteriovenous malformation


Vault hold - ✔✔✔ Correct Answer > Index on greater wings of sphenoid
Middle on zygomatic process of temporal bone (ant to ear)
Ring on mastoid process of temporal bone (post to ear)
D


Little finger on occiput
O


Thumbs over sagittal suture
N
O


Unpasteurized goat cheese - ✔✔✔ Correct Answer > Brucella
T
C


Laxative abuse - ✔✔✔ Correct Answer > electrolyte imbalance
O
PY


Severe dehydration
Dependency
Stretched or "lazy" colon


Balantidium coli - ✔✔✔ Correct Answer > protozoa that causes GI infection, ingest
cysts thru infected water or food
Produces hyalonuridase and creates ulcers in mucosal walls


Isospora belli - ✔✔✔ Correct Answer > diarrhea, steatorrhea, malabsorption, non-
bloody diarrhea

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