PCB 3233 Exam 2 Study Guide 2026/2027 | Practice Questions, Answers & Exam Review

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PCB 3233 EXAM 2
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1. Induced innate immune re- -Inflammation
sponse -Leukocytes called into the site of infection
-Soluble molecules made and secreted
into the blood and brought to the site of the
infection

2. Leukocytes in the order to ac- 1. Neutrophils - Mass quantities
tion 2. Monocytes
3.Lymphocytes - days later

3. 2 cell type recognition 1. NK - looking at your own cells
2. Macrophages - looking at pathogen di-
rectly

4. Macrophages use toll like receptors and phagocytic re-
ceptors

5. PAMP pathogen associated molecular patterns -
on pathogen

6. PRR pattern recognition receptors - on leuko-
cyte

7. Are there different receptor yes
used for phagocytosis vs. cy-
tokine creation and secre-
tion(signalling)?

8. What are the 5 cytokines? IL-1
TNF-a
IL-6
CXCL8
IL-12

9. Which cytokines are pyro- IL-1
gens? TNF-a
IL-6

10. What do heat cytokines (Pyro- Lead to fever
gens) lead to?

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11. Which cytokines activate en- IL-1 and TNF-a
dothelial cells?

12. What does the activation of en- Vasodilation and Vascular premeability
dothelial cells lead to?

13. NK cells provides an early re- Viral Infection
sponse for which kind of infec-
tion?

14. NK recognizes two types of re- Activating receptors and inhibitory recep-
ceptors tors

15. Activating receptors recognize (Stress induced) activating ligands which
leads to apoptosis.

16. Inhibitory receptors recog- MHC 1 on all nucleated cells.
nizes

17. 1st effector cell Resident Macrophages which is prevalent
in connective tissues

18. CR1 (complement receptor 1) C3b
binds to?

19. C3b is degraded by what to be- Factor I
come iC3b?

20. NK cells can detect? MHC molecules

21. Which receptor can recognize Scavenger Receptor A (SR-A)
both Gram(-) and Gram(+)?

22. Which leukocyte would be first Neutrophils
out to the sight of infection in
mass quantities?

23. Macrophages Receptors Mannose Receptor
(PRR): CR-3


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CR-4
Dectin-1
SR-A (Scavenger Receptor-A)
SR-B (Scavenger Receptor - B)
LPS (also known as CD14)
TLR
MARCO

24. Can all nucleated cells use yes
MHC 1?

25. Macrophages are longlived Neutrophils
compared to what?

26. What can CR1 do for you? Bind to C3b and phagocytose what ever
C3b is bound to

27. What are the 4 TLRs(Toll-Like TLR-3
Receptors)? TLR-7
TLR-5
TLR-4

28. What are the internal TLRs? TLR-3:Double stranded Viral RNA
TLR-7: Single stranded Viral RNA

29. What does CR-3 and CR-4 rec- iC3b and LPS
ognize?

30. Can MBL an opsonin? yes

31. What does mannose binding It binds to Mannose and it's a lectin.
lectin bind to?

32. Toll-like receptors leads to? Signaling

33. All of the macrophage recep- Phagocytosis
tors EXCEPT for TLRs leads
to?

34. What are the external TLRs

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