Hematology | Questions with 100% Verified Answers | Latest Update 2026/2027

Hematology | Questions with 100% Verified Answers | Latest
Update 2026/2027
Question: List three ways to describe the genetic abnormality in CML?
Answer: 922 - BCR-ABL gene - Philadelphia chromosome

Question: What leukemia would lymphoblast be associated with?
Answer: ALL (Blasts = Acute)

Question: What leukemia would myeloblasts be associated with?
Answer: AML (Blasts = Acute)

Question: What gene mutation is associated with polycythemia vera?
Answer: JAK2 mutation

Question: TTP symptom Mnemonic: FAT-RN. What dose FAT-RN stand for?
Answer: Fever - Anemia - Thrombocytopenia - Renal failure - Neurologic involvement

Question: List two conditions which predispose a patient to antiphospholipid syndrome.
Answer: Systemic Lupus Erythematosus - Women with recurrent abortions

Question: What disorder is a hemoglobin electrophoresis result of "SA" indicative of?
Answer: Sickle cell trait

Question: What disorder is a hemoglobin electrophoresis result of "SS" indicative of?
Answer: Sickle cell disease

Question: What type of anemia are cephalosporins PCN NSAIDS methyldopa associated with?
Answer: Immune hemolytic anemia

Question: Erythropoietin analogs should be suspended once the hemoglobin is >_____?
Answer: 11 mg/dl

Question: Erythropoietin analogs should only be initiated if the hemoglobin is < ____?
Answer: 10 mg/dl

Question: What two types of anemia have macroovalocytes?
Answer: B12 and folate deficiency

Question: Which anemia has a decreased MCV, decreased MCH (hypochromic) yet normal TIBC and ferritin?
Answer: Thalassemia

Question: Acute chest syndrome occurs during the acute phase of which anemia?
Answer: Hemolytic sickle cell crisis

, Question: What are some common oxidative events which may trigger hemolysis in G6PD deficiency?
Answer: Antimalarials - Sulfa drugs - Aspirin - Febrile Illness - Acidosis - Fava beans

Question: What type of anemia does a + osmotic fragility test indicate?
Answer: Hereditary Spherocytosis

Question: What do an increased LDH, decreased Haptoglobin and an increased indirect Bilirubin represent?
Answer: Hemolysis

Question: What type of anemia does a + direct coombs indicate?
Answer: Autoimmune hemolytic anemia

Question: What does a > 50% reduction in platelet count within 7-10 days of exposure to heparin define?
Answer: Heparin Induced Thrombocytopenia (HIT) syndrome

Question: Which type of anemia is most likely with associated leukopenia and thrombocytopenia?
Answer: Aplastic anemia

Question: How would you expect TIBC and ferritin to present in anemia of chronic disease?
Answer: Decreased TIBC - Normal/increased Ferritin

Question: Anemia of renal failure is defined by decreased levels of which hormone?
Answer: Erythropoietin

Question: Can oral B12 be used as an initial treatment in a B12 deficient patient?
Answer: Yes - Oral B12 is considered initial therapy - Other routes if oral fails or pernicious anemia is diagnosed

Question: Which route is best for administering B12 to a deficient patient?
Answer: Sublingual IM or deep subcutaneous

Question: What tests other than a Schilling test are used to diagnose pernicious anemia?
Answer: Increased Methylmalonic acid levels - + Intrinsic factor and parietal cell antibodies

Question: Increased MCV with smooth tongue, loss of proprioception and vibratory sense is likely which type of
anemia?
Answer: B12 deficiency

Question: List 5 common causes of folate deficiency.
Answer: EtOH abuse - Advancing age - Gastric bypass - Pregnancy - Methotrexate

Question: What symptom differentiates B12 from folate deficiency ?
Answer: Neuropathy occurs with B12 deficiency but not with folate deficiency

Question: Slowly decreasing MCV in an elderly patient?
Answer: Occult GI blood loss