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CPNRE Practice Questions 2026 | Canadian Practical Nurse Exam Prep, Answers, Rationales & Review

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Prepare for the Canadian Practical Nurse Registration Examination (CPNRE) with this comprehensive 2026 practice and exam review resource featuring exam-style questions, answers, and detailed rationales. The material covers key areas including health assessment, nursing care, clinical judgment, pharmacology, medical-surgical nursing, mental health, maternal and newborn care, pediatric nursing, community health, patient safety, ethics, professional practice, and prioritization. Clinical scenarios and practice questions are designed to help strengthen decision-making and apply nursing knowledge to realistic situations. Ideal for CPNRE preparation, Canadian practical nursing students, mock exams, practice tests, and comprehensive nursing review.

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CPNRE Practice Questions
2026 | Canadian Practical
Nurse Exam Prep,
Answers, Rationales &
Review | Complete Ethics
Study Guide




Updated 2026 Questions and Answers
100% Verified Exam Prep and Comprehensive
Rationales
Included

,The nurse is administering heparin via the subcutaneous Prepare the medication using a 25-gauge, ½ inch needle
route. Which intervention should the nurse implement? Knowledge: The nurse should NOT aspirate for blood when administering heparin
because this can damage surrounding tissue and cause bruising. The nurse should
a. Prepare the medication using a 25-gauge, ½ inch not massage after injecting heparin because this may cause bruising or bleeding.
needle Heparin is administered in the abdomen at least 2 inches from umbilicus-best
b. After injecting the needle, aspirate and observe for practice.
blood
c. After removing the needle, massage the area gently
d. Administer the medication in the client's "love handles"


The nurse is administering morning medications on a a. Regular insulin sliding scale to an elderly client diagnosed with Type 1
medical floor. Which medication should the nurse diabetes mellitus
administer first? b. Methylprednisolone, a glucocorticoid, to a client diagnosed with lupus
erythematosus (can be administered within the 30-minute acceptable time frame)
a. Regular insulin sliding scale to an elderly client c. Morphine, a narcotic analgesic, to a client diagnosed with AIDS -pain medication
diagnosed with Type 1 diabetes mellitus is a priority, but it can be administered after the sliding scale
b. Methylprednisolone, a glucocorticoid, to a client d. Lasix, a diuretic, to a client with hypertension- can be administered within the 30-
diagnosed with lupus erythematosus minute acceptable time frame
c. Morphine, a narcotic analgesic, to a client diagnosed Regular insulin is administered prior to meals; therefore, this medication should be
with AIDS administered. Critical Thinking
d. Lasix, a diuretic, to a client with hypertension


Which data would indicate that the antibiotic therapy has a. The client’s hematocrit is within normal range- does not indicate client response
been successful for a client diagnosed with bacterial b. The client is expectorating thick green sputum- symptom of pneumonia
pneumonia? c. The client’s lung sounds are clear to ausculatation
d. The client has complaints of pleuritic chest pain.— symptom of pneumonia
a. The client's hematocrit is within normal range The symptoms of pneumonia includes crackles and wheezes, rhonchi in the lung
b. The client is expectorating thick green sputum fields. Clear lungs indicate an improvement in the pneumonia and that the
c. The client's lung sounds are clear to ausculatation medication is effective. Application
d. The client has complaints of pleuritic chest pain.


The nurse is administering Humalog at 0730 to a client a. Ensure the client eats at least 90% of the lunch tray—insulin will not be working
diagnosed with Type 1 diabetes. Which intervention should 4-5 hours after being administered
the nurse implement? b. Do not administer unless the breakfast tray is in the client’s room
c. Check the client’s blood glucose level 1 hour after receiving the insulin—glucose
a. Ensure the client eats at least 90% of the lunch tray level should be checked prior to administering
b. Do not administer unless the breakfast tray is in the d. Have 50% dextrose in water at the bedside for emergency use.—this is
client's room administered when a client is unconscious secondary to hypoglycemia, and should
c. Check the client's blood glucose level 1 hour after not be kept at the bedside. Orange juice or some form of simple glucose can be
receiving the insulin kept at the bedside.
d. Have 50% dextrose in water at the bedside for Application: The insulin peaks in 15-20 minutes after being administered; therefore,
emergency use. the meal should be at the bedside prior to administering this medication


The client has a severe anaphylactic reaction to insect a. Wear an insect repellent on exposed skin —appropriate intervention, but if the
bites. What priority discharge intervention should the nurse client has an insect bite, the repellent will not prevent anaphylaxis, therefore, not
discuss with the client? priority intervention
b. Keep prescribed antihistamines on their person —used with anaphylaxis, but it
a. Wear an insect repellent on exposed skin takes at least 30 minutes to work, therefore not a priority medication
b. Keep prescribed antihistamines on their person c. Keep an EpiPen in the refrigerator at all times —keeping medication in the
c. Keep an EpiPen in the refrigerator at all times refrigerator does not allow it to be available to the client at all times.
d. Wear a MedicAlert identification bracelet d. Wear a MedicAlert identification bracelet
Application: Bracelet indicates the client is at risk for an anaphylactic reaction;
therefore, this is the priority intervention.


The client's mother contacts the clinic regarding d. Stop the medication and inform the physician
medication administration stating, "My daughter cannot Application: SR means sustained released. These medications cannot be altered. In
swallow this capsule. It's too large." Investigation reveals answers A and B, crushing or opening the capsule is not allowed. The best
that the medication is a capsule marked SR. The nurse response would be to inform the prescriber (the doctor) immediately
should instruct the mother to:

a. Open the capsule and mix the medication with apple
sauce
b. Crush the medication and administer it with a glass of
liquid
c. Call the pharmacist and request a change to a different
medication
d. Stop the medication and inform the physician

,The client calls the nursing station and requests pain a. Administer the client’s prescribed pain medication —should not administer pain
medication. When the nurse enters the room with the medication until after assessing the client’s pain
narcotic medication, the nurse finds the client laughing and b. Assess the client’s perception of pain on a 1-10 scale
talking with visitors. Which action should the nurse c. Wait until the visitors leave to administer any medication —should assess client
administer first? whether the client has visitors or not
d. Check the MAR to see if there is a nonnarcotic medication ordered —nurse
a. Administer the client's prescribed pain medication should assess the client’s pain first
b. Assess the client's perception of pain on a 1-10 scale Application: first action is to always assess the client in pain to determine if client is
c. Wait until the visitors leave to administer any medication having a complication that requires medical intervention rather than PRN
d. Check the MAR to see if there is a nonnarcotic medication.
medication ordered


The client in hypovolemic shock is receiving normal saline a. The client’s blood pressure is 89/48
by rapid intravenous infusion. Which assessment data b. The client’s pulse oximeter reading is 95% --normal finding
would warrant immediate intervention by the nurse? c. The client’s lung sounds are clear bilaterally—normal finding
d. The client’s urine output is 120 mL in 3 hours—normal finding
a. The client's blood pressure is 89/48 Application: low blood pressure reading for a client in hypovolemic shock. A B/P less
b. The client's pulse oximeter reading is 95% than 90/60 warrants intervention by the nurse and indicates that fluid resuscitation is
c. The client's lung sounds are clear bilaterally not effective.
d. The client's urine output is 120 mL in 3 hours


Which intervention should the nurse implement when a. Insert the needle with the bevel up at 15-degree angle in the skin
administering a medication via the intradermal route? b. Prepare the medication in a 3-mL syringe using a 23-gauge 1-inch needle —
wrong syringe (need tuberculin syringe), wrong gauge, and wrong needle
a. Insert the needle with the bevel up at 15-degree angle in c. Bunch the skin between the thumb and index finger of the nondominant hand---
the skin skin should be spread taut, not bunched
b. Prepare the medication in a 3-mL syringe using a 23- d. Quickly inject the medication as to not form a wheal or bleb—medication should
gauge 1-inch needle be injected slowly to form a wheal or bleb
c. Bunch the skin between the thumb and index finger of Knowledge: A is the correct way to administer intradermal medication
the nondominant hand
d. Quickly inject the medication as to not form a wheal or
bleb


The charge nurse is observing the primary nurse a. Stop the primary nurse and ask the nurse to step out of the room
administering otic drops to a 2-year-old child by pulling b. Demonstrate inserting the otic drops by pulling up and back on the auricle—
down and back on the auricle. Which action should the correct way for adults
charge nurse take? c. Take no action because this is the correct way to administer the ear drops
d. Allow the nurse to administer the otic drops and then discuss the technique with
a. Stop the primary nurse and ask the nurse to step out of the nurse
the room Knowledge: This is the correct way to administer eardrops to a child younger than 3.
b. Demonstrate inserting the otic drops by pulling up and This is done because of the short Eustachian tube of a child. The charge nurse
back on the auricle need take no action
c. Take no action because this is the correct way to
administer the ear drops
d. Allow the nurse to administer the otic drops and then
discuss the technique with the nurse


The nurse prepared 2 mg of morphine for a client who is a. Explain that the medication must be administered because it has been drawn up
complaining of pain. When the nurse enters the room the —client has the right to refuse medication; therefore; the nurse cannot force the
client tells the nurse, "I don't want to take a shot. I would client to take the med.
like to have a pain pill." Which action should the nurse b. Ask another nurse to watch the medication being wasted into the sink
take? c. Place the syringe in the sharps container in the client’s room—legally the nurse
must have someone witness the narcotic being wasted
a. Explain that the medication must be administered d. Notify the pharmacy that a narcotic was not administered to the client—does not
because it has been drawn up need to be notified
b. Ask another nurse to watch the medication being Application: Correct procedure as per CNO medication standards of practice
wasted into the sink
c. Place the syringe in the sharps container in the client's
room—
d. Notify the pharmacy that a narcotic was not
administered to the client


The nurse is preparing to adminster 3 mL of a medication a. The deltoid muscle —1-2 mL max. at this site, muscle is small
intramuscularly to an adult client in the clinic. Which b. The dorsogluteal muscle— not recommended because the sciatic nerve may be
muscle is the best site to administer the medication? injured if landmarking is improper
c. The ventrogluteal muscle
a. The deltoid muscle d. The vastus lateralis muscle— can be used, but is more painful
b. The dorsogluteal muscle Knowledge: site of choice is C, free of major nerves and adipose tissue to ensure
c. The ventrogluteal muscle medication goes in the muscle. It is also a larger mass of muscle.
d. The vastus lateralis muscle

, The nurse is administering medications through a a. Place the crushed pills in the gastrostomy tube.—Not first intervention
gastrostomy tube (GT). Which intervention should the b. Flush the gastrostomy with at least 30 mL of tap water
nurse implement first? c. Use the plunger to push the medication into the GT- not first intervention
d. Clamp the gastrostomy tube closed.— performed after medication is
a. Place the crushed pills in the gastrostomy tube. administered
b. Flush the gastrostomy with at least 30 mL of tap water Knowledge: Nurse should first flush the GT with tap water to ensure it is patent
c. Use the plunger to push the medication into the GT before putting any medication into the GT.
d. Clamp the gastrostomy tube closed.


The charge nurse is making rounds on the clients and a. Administer the client’s medications—charge nurse cannot administer without
notices the primary nurse left a medication cup with three verifying medications against MAR
tablets at the client's bedside. Which action should the b. Remove the medication cup from the room
charge nurse implement? c. Request the primary nurse come to the room—charge nurse should not correct
the primary nurse in front of client
a. Administer the client's medications d. Leave the cup at the bedside and talk to the primary nurse
b. Remove the medication cup from the room Application: The nurse should take the medication cup back to the medication room
c. Request the primary nurse come to the room and discuss this situation with the primary nurse. Medications should never be left
d. Leave the cup at the bedside and talk to the primary at the bedside.
nurse


1. The client in end-stage renal disease is receiving oral a. The client’s serum potassium level is 5.8 mEq/L
Kayexalate. Which assessment data indicates the b. The client’s serum sodium level is 135 mEq/L —does not alter sodium levels (not
medication is not effective? used for this)
c. The client’s serum postassium level is 4.2 mEq/L—normal level
a. The client's serum potassium level is 5.8 mEq/L d. The client’s serum sodium level is 147 mEq/L (see above)
b. The client's serum sodium level is 135 mEq/L Application: Kayexalate is a medication used to decrease potassium levels. A is an
c. The client's serum postassium level is 4.2 mEq/L elevated level, therefore, medication is not effective.
d. The client's serum sodium level is 147 mEq/L


Which of the following interventions would be a priority in b. Intravenous aminophylline
the plan of care for the person with pulmonary c. Maintain hydration status
emphysema? (Select all that apply) Application Question: Since emphysema is a chronic disorder, the patient will be
required to wear oxygen continuously, therefore nasal canula is the best way to
a. Low flow oxygen via face mask deliver the low levels of oxygen. Aminophylline is a bronchodilator used as
b. Intravenous aminophylline maintenance therapy. Hydration is necessary, but not overhydration. Ampicillin
c. Maintain hydration status therapy is not considered a typical intervention in the management of emphysema.
d. Intravenous ampicillin therapy


The practical nurse enters Mrs. Stem's room to administer a. “Let me check the medication order again and I’ll be back in a few
the 0800 Hours insulin dose. Mrs. Stem states , "That is minutes.”
not my usual dose of insulin. " How should the nurse APPLICATION QUESTION--According to the CNO compendium –medication
respond to Mrs. Stem? standards---YOU SHOULD ALWAYS CHECK/VALIDATE ANY MEDICATION
/ORDER THAT THE PATIENT THEMSELVES QUESTIONS. “BEST PRACTICE”
a. "Let me check the medication order again and I'll be
back in a few minutes."
b. "I'll check with my colleague, who is right here to see if
this is the right dose."
c. "I saw your insulin order about 1 hour ago and this what
the physician ordered."
d. "Mrs. Stem, I know what I am doing and you should trust
me, this is the correct dose."


Mrs. Soh, 65 years old, is 3 days postoperative. She is c. Auscultate bowel sounds
experiencing nausea and vomiting. What should the nurse CRITICAL THINKING QUESTION--. Yes, you will document this event, but you
do? would manage the patient first in this case. Complete an assessment, then
intervene. Bowel sounds are one aspect of an assessment of peristalsis. This will
a. Place bed in semi-Fowler's (45 degrees) help determine if the intestines are functioning, and rule out bowel obstruction or
b. Document client condition other disorders.
c. Auscultate bowel sounds
d. Provide a glass of water


A 19-year-old with acute asthma has come into the E.R in b. Administer bronchodilator via nebulizer
acute respiratory distress. His breath rate is 44 Critical Thinking Question: Follow Protocol ABC’s First, then Nursing Process. In
breaths/minute. Which of the following interventions should this case, it is an emergency, therefore we follow ABC’s. The patient is experiencing
the nurse anticipate first? an acute asthma attack, we will administer bronchodilator to open up the airway.
Once the acute phase is over, we can consider the other interventions.
a. Obtain a complete health history
b. Administer bronchodilator via nebulizer
c. Provide emotional support to the client
d. Apply a cardiac monitor to the client

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