T2 EX5 L1 (MEDCHEM ANTIDEPRESSANTS & ANXIOLYTICS)
(JINWAL) EXAM WITH COMPLETE SOLUTIONS 100% VERIFIED!!!!
ALREADY GRADED A+
Diagnostic criteria for major depressive disorder? - (answer)SIGECAPS Questionnaire - Sleep, Interest,
Guilt, Energy, Concentration, Appetite, Psychomotor, Suicide
At least 5 symptoms must be consistently present over a 2-week period
T/F: Depression is associated with significant functional disability, morbidity, and mortality. -
(answer)True
Monoamine hypothesis of major depressive disorder - (answer)A deficiency or imbalances in the
monoamine neurotransmitters (serotonin, norepinephrine, dopamine) causes depression
Based on the monoamine hypothesis of MDD, how can we ameliorate depression - (answer)Increasing 5-
HT and NE neurotransmission
Per the monoamine hypothesis of MDD, a ___________ synaptic concentration of 5-HT and/or NE
causes depression.
A. Increased
B. Decreased - (answer)B. Decreased
Give me the rundown on the hypercholinergic hypothesis of depression - (answer)Hyperactivity of
cholinergic system + excessive neuronal nicotinic acetylcholine receptor activity (nACHR) -> depression
What drugs are used to treat MDD according to the hypercholinergic hypothesis of depression? -
(answer)Bupropion
Nicotinic transdermal patch
,T2 EX5 L1 (MEDCHEM ANTIDEPRESSANTS & ANXIOLYTICS)
(JINWAL) EXAM WITH COMPLETE SOLUTIONS 100% VERIFIED!!!!
ALREADY GRADED A+
Give me the rundown on the postsynaptic receptor sensitivity hypothesis - (answer)Hypersensitivity of
postsynaptic receptors due to low conc. in synaptic cleft -> decreased sensitivity and decreased number
of receptors over time -> depression
Give me the rundown on the permissive hypothesis of MDD - (answer)The balance between NE and 5-HT
in regulating mood and not the absolute levels of the neurotransmitters
Give me the rundown on the hormonal hypothesis of MDD - (answer)Hypothalamus-pituitary-adrenal
axis (HPA): elevated CRH levels, corticosteroids modulate 5-HT synthesis, metabolism, and uptake
Neuroendocrine system: abnormal thyroid function test (low T3/T4)
Serotonin and norepinephrine regulate... (six) - (answer)1. Mood
2. Sleep-wake cycle
3. Motivation
4. Reward
5. Cognitive processing
6. Other physiological processes
Serotoninergic projections to the forebrain modulate... (three) - (answer)1. Mood
2. Cognition
3. Neuroendocrine function
The noradrenergic system modulates... (five) - (answer)1. Vigilance
2. Stress responses
3. Neuroendocrine function
4. Pain control
, T2 EX5 L1 (MEDCHEM ANTIDEPRESSANTS & ANXIOLYTICS)
(JINWAL) EXAM WITH COMPLETE SOLUTIONS 100% VERIFIED!!!!
ALREADY GRADED A+
5. Sympathetic nervous system activity
Precursor to serotonin? - (answer)Tryptophan
Norepinephrine synthesis pathway? (three steps) - (answer)Tyrosine -> L-DOPA -> Dopamine
Which enzyme oxidizes tyrosine to L-DOPA? - (answer)Tyrosine hydroxylase
T/F: For all monoamines, the 1st synthetic step is rate-limiting. - (answer)True
T/F: The rate-limiting step enzymes involved in monoamine synthesis are regulated by feedback
inhibition via autoreceptors located presynaptically. - (answer)True
Role of VMAT? - (answer)Transport 5-HT into vesicles (nonspecific)
Role of reserpine? - (answer)Bind irreversibly to VMAT, inhibits packaging of monoamine NTs into
vesicles
Role of SERT/NET? - (answer)Serotonin/NE reuptake transporters
Recycle 5-HT/NE from extracellular space back into presynaptic terminals
5-HT is degraded by what enzyme? - (answer)Monoamine oxidase
Bonus points: COMT, but not so important for MDD
(JINWAL) EXAM WITH COMPLETE SOLUTIONS 100% VERIFIED!!!!
ALREADY GRADED A+
Diagnostic criteria for major depressive disorder? - (answer)SIGECAPS Questionnaire - Sleep, Interest,
Guilt, Energy, Concentration, Appetite, Psychomotor, Suicide
At least 5 symptoms must be consistently present over a 2-week period
T/F: Depression is associated with significant functional disability, morbidity, and mortality. -
(answer)True
Monoamine hypothesis of major depressive disorder - (answer)A deficiency or imbalances in the
monoamine neurotransmitters (serotonin, norepinephrine, dopamine) causes depression
Based on the monoamine hypothesis of MDD, how can we ameliorate depression - (answer)Increasing 5-
HT and NE neurotransmission
Per the monoamine hypothesis of MDD, a ___________ synaptic concentration of 5-HT and/or NE
causes depression.
A. Increased
B. Decreased - (answer)B. Decreased
Give me the rundown on the hypercholinergic hypothesis of depression - (answer)Hyperactivity of
cholinergic system + excessive neuronal nicotinic acetylcholine receptor activity (nACHR) -> depression
What drugs are used to treat MDD according to the hypercholinergic hypothesis of depression? -
(answer)Bupropion
Nicotinic transdermal patch
,T2 EX5 L1 (MEDCHEM ANTIDEPRESSANTS & ANXIOLYTICS)
(JINWAL) EXAM WITH COMPLETE SOLUTIONS 100% VERIFIED!!!!
ALREADY GRADED A+
Give me the rundown on the postsynaptic receptor sensitivity hypothesis - (answer)Hypersensitivity of
postsynaptic receptors due to low conc. in synaptic cleft -> decreased sensitivity and decreased number
of receptors over time -> depression
Give me the rundown on the permissive hypothesis of MDD - (answer)The balance between NE and 5-HT
in regulating mood and not the absolute levels of the neurotransmitters
Give me the rundown on the hormonal hypothesis of MDD - (answer)Hypothalamus-pituitary-adrenal
axis (HPA): elevated CRH levels, corticosteroids modulate 5-HT synthesis, metabolism, and uptake
Neuroendocrine system: abnormal thyroid function test (low T3/T4)
Serotonin and norepinephrine regulate... (six) - (answer)1. Mood
2. Sleep-wake cycle
3. Motivation
4. Reward
5. Cognitive processing
6. Other physiological processes
Serotoninergic projections to the forebrain modulate... (three) - (answer)1. Mood
2. Cognition
3. Neuroendocrine function
The noradrenergic system modulates... (five) - (answer)1. Vigilance
2. Stress responses
3. Neuroendocrine function
4. Pain control
, T2 EX5 L1 (MEDCHEM ANTIDEPRESSANTS & ANXIOLYTICS)
(JINWAL) EXAM WITH COMPLETE SOLUTIONS 100% VERIFIED!!!!
ALREADY GRADED A+
5. Sympathetic nervous system activity
Precursor to serotonin? - (answer)Tryptophan
Norepinephrine synthesis pathway? (three steps) - (answer)Tyrosine -> L-DOPA -> Dopamine
Which enzyme oxidizes tyrosine to L-DOPA? - (answer)Tyrosine hydroxylase
T/F: For all monoamines, the 1st synthetic step is rate-limiting. - (answer)True
T/F: The rate-limiting step enzymes involved in monoamine synthesis are regulated by feedback
inhibition via autoreceptors located presynaptically. - (answer)True
Role of VMAT? - (answer)Transport 5-HT into vesicles (nonspecific)
Role of reserpine? - (answer)Bind irreversibly to VMAT, inhibits packaging of monoamine NTs into
vesicles
Role of SERT/NET? - (answer)Serotonin/NE reuptake transporters
Recycle 5-HT/NE from extracellular space back into presynaptic terminals
5-HT is degraded by what enzyme? - (answer)Monoamine oxidase
Bonus points: COMT, but not so important for MDD
