Practice Examination | High-Yield Nutrition Questions, Answers &
Detailed Rationales | Nutrients, Digestion, Metabolism, Therapeutic
Diets, Nutrition Across the Lifespan & Patient Education | Complete
Study Guide
Question 1
A 45-year-old patient with newly diagnosed type 2 diabetes reports consuming large amounts of fruit
juice daily to "get enough vitamins." Which carbohydrate-related concept best explains why this
practice may be counterproductive for glycemic control?
A. Fruit juice contains primarily insoluble fiber which delays gastric emptying
B. The glycemic load of fruit juice is typically lower than whole fruit
C. Fruit juice lacks the viscous soluble fiber found in whole fruit, leading to rapid glucose absorption
D. The fructose in fruit juice requires insulin for cellular uptake
Correct Answer: C
Explanation: Whole fruit contains soluble fiber that forms a gel in the GI tract, slowing glucose
absorption. Fruit juice lacks this protective fiber, causing rapid glycemic spikes and increased insulin
demand.
Question 2
During prolonged fasting, the body maintains blood glucose homeostasis through gluconeogenesis.
Which substrate is the PRIMARY precursor for this process?
A. Fatty acids
B. Ketone bodies
C. Amino acids (particularly alanine)
,D. Glycerol
Correct Answer: C
Explanation: Amino acids, especially alanine from muscle protein breakdown, serve as the primary
gluconeogenic substrates. Fatty acids cannot be converted to glucose due to the irreversible nature of
pyruvate dehydrogenase.
Question 3
A nutritionist is evaluating a new breakfast cereal that claims to be "low glycemic index." Which
physiological response would confirm that this claim is accurate?
A. Rapid insulin spike with subsequent hypoglycemia
B. Elevated blood glucose >160 mg/dL within 30 minutes
C. Gradual, sustained increase in blood glucose with moderate insulin response
D. Immediate glucagon secretion and glycogen breakdown
Correct Answer: C
Explanation: Low glycemic index foods produce a gradual, sustained glucose elevation with moderate
insulin demand, reducing postprandial metabolic stress and promoting satiety.
Question 4
A patient with lactose intolerance experiences symptoms after consuming dairy. Which metabolic
process best explains the mechanism of symptom development?
A. Bacterial fermentation of undigested lactose producing hydrogen gas and organic acids
B. Autoimmune destruction of intestinal lactase-producing enterocytes
C. Defective glucose-galactose transport across the intestinal brush border
D. Excessive gastric acid secretion triggered by lactose ingestion
,Correct Answer: A
Explanation: Undigested lactose reaches the colon where gut bacteria ferment it, producing hydrogen,
methane, carbon dioxide, and short-chain fatty acids, causing osmotic diarrhea and gas.
Question 5
The human body stores glycogen in two primary locations. What percentage of the body's total
glycogen is stored in the liver?
A. Approximately 10%
B. Approximately 25%
C. Approximately 33%
D. Approximately 50%
Correct Answer: B
Explanation: The liver contains approximately 25% of total body glycogen (about 100g), while skeletal
muscle stores the remaining 75% (approximately 400g) due to greater muscle mass.
Question 6
Which metabolic adaptation occurs when carbohydrate intake is severely restricted (<50g/day) for 7-
10 days?
A. Increased glycolysis with elevated lactate production
B. Upregulation of glucose transporters (GLUT4) in adipose tissue
C. Shift toward ketogenesis with elevated blood ketone bodies
D. Enhanced glycogen synthase activity in liver and muscle
Correct Answer: C
, Explanation: During severe carbohydrate restriction, the liver increases ketogenesis to produce
alternative fuel sources (acetoacetate, beta-hydroxybutyrate) for brain and other tissues.
Question 7
A 28-year-old athlete consumes a carbohydrate-rich meal 3 hours before competition. What is the
PRIMARY purpose of this nutritional practice?
A. To maximize liver glycogen stores for sustained energy
B. To promote muscle glycogen synthesis during exercise
C. To prevent exercise-induced hypoglycemia during performance
D. To stimulate protein synthesis and muscle repair
Correct Answer: A
Explanation: Pre-exercise carbohydrate loading maximizes liver glycogen stores, providing sustained
blood glucose availability during prolonged activity and preventing hypoglycemia.
Question 8
The glycemic index of a food is determined by comparing its blood glucose response to that of which
reference food?
A. Sucrose (table sugar)
B. Fructose
C. Glucose or white bread
D. Honey
Correct Answer: C