HESI RN HEMATOLOGY NURSING ACCURATE
COMPREHENSIVE PRACTICE EXAM WITH ALL
POSSIBLE APPROVED WELL ELABORATED
PRACTICE QUESTIONS AND 100% CORRECT
VERIFIED ANSWERS WITH DETAILED RATIONALES
PLUS EXPERT ANSWER KEY (100% CORRECT
VERIFIED SOLUTIONS) 2026-2027 CURRENTLY
UPDATED VERSION Q&A GUARANTEED PASS A+
INSTANT DOWNLOAD PDF
1. A client with anemia reports feeling cold and has
a heart rate of 110 beats per minute. Which
physiological mechanism is the body using to
compensate for the decreased oxygen-carrying
capacity?
a. Decreased cardiac output
b. Peripheral vasodilation
c. Increased heart rate and peripheral
,vasoconstriction
d. Decreased respiratory rate
Correct Answer: c. Increased heart rate and
peripheral vasoconstriction
Rationale: In response to anemia-induced hypoxia,
the body increases cardiac output through
tachycardia and redirects blood to vital organs via
peripheral vasoconstriction. This compensatory
mechanism attempts to maintain adequate tissue
oxygenation despite reduced hemoglobin levels.
2. The nurse is assessing a client with a suspected
diagnosis of pernicious anemia. Which finding is
most consistent with this condition?
a. Microcytic, hypochromic red blood cells
b. Absence of intrinsic factor leading to vitamin B12
malabsorption
c. Iron deficiency from chronic blood loss
d. Elevated serum ferritin levels
Correct Answer: b. Absence of intrinsic factor
leading to vitamin B12 malabsorption
Rationale: Pernicious anemia results from the
autoimmune destruction of gastric parietal cells,
,which produce intrinsic factor. Without intrinsic
factor, vitamin B12 cannot be absorbed in the
terminal ileum, leading to megaloblastic anemia
and neurological symptoms.
3. A client with sickle cell crisis is experiencing acute
chest pain and shortness of breath. What is the
priority nursing intervention?
a. Administer oral fluids
b. Apply oxygen and prepare for possible exchange
transfusion
c. Encourage ambulation
d. Place the client in a Trendelenburg position
Correct Answer: b. Apply oxygen and prepare for
possible exchange transfusion
Rationale: Acute chest syndrome is a life-
threatening complication of sickle cell disease
characterized by pulmonary infiltrates and
hypoxia. The priority is to administer supplemental
oxygen and prepare for exchange transfusion to
reduce sickle hemoglobin concentration and
improve oxygenation.
, 4. The nurse is reviewing laboratory results for a
client with chronic kidney disease. Which finding is
most indicative of anemia of chronic disease?
a. Low serum erythropoietin level
b. Elevated mean corpuscular volume
c. High serum iron level
d. Decreased total iron-binding capacity
Correct Answer: a. Low serum erythropoietin level
Rationale: In chronic kidney disease, the kidneys
fail to produce adequate erythropoietin, which is
essential for stimulating red blood cell production
in the bone marrow. This results in a normocytic,
normochromic anemia that is responsive to
exogenous erythropoietin therapy.
5. A client diagnosed with hemophilia A is admitted
after a minor injury. Which medication order should
the nurse question?
a. Acetaminophen
b. Aspirin
c. Desmopressin
d. Factor VIII concentrate
Correct Answer: b. Aspirin
COMPREHENSIVE PRACTICE EXAM WITH ALL
POSSIBLE APPROVED WELL ELABORATED
PRACTICE QUESTIONS AND 100% CORRECT
VERIFIED ANSWERS WITH DETAILED RATIONALES
PLUS EXPERT ANSWER KEY (100% CORRECT
VERIFIED SOLUTIONS) 2026-2027 CURRENTLY
UPDATED VERSION Q&A GUARANTEED PASS A+
INSTANT DOWNLOAD PDF
1. A client with anemia reports feeling cold and has
a heart rate of 110 beats per minute. Which
physiological mechanism is the body using to
compensate for the decreased oxygen-carrying
capacity?
a. Decreased cardiac output
b. Peripheral vasodilation
c. Increased heart rate and peripheral
,vasoconstriction
d. Decreased respiratory rate
Correct Answer: c. Increased heart rate and
peripheral vasoconstriction
Rationale: In response to anemia-induced hypoxia,
the body increases cardiac output through
tachycardia and redirects blood to vital organs via
peripheral vasoconstriction. This compensatory
mechanism attempts to maintain adequate tissue
oxygenation despite reduced hemoglobin levels.
2. The nurse is assessing a client with a suspected
diagnosis of pernicious anemia. Which finding is
most consistent with this condition?
a. Microcytic, hypochromic red blood cells
b. Absence of intrinsic factor leading to vitamin B12
malabsorption
c. Iron deficiency from chronic blood loss
d. Elevated serum ferritin levels
Correct Answer: b. Absence of intrinsic factor
leading to vitamin B12 malabsorption
Rationale: Pernicious anemia results from the
autoimmune destruction of gastric parietal cells,
,which produce intrinsic factor. Without intrinsic
factor, vitamin B12 cannot be absorbed in the
terminal ileum, leading to megaloblastic anemia
and neurological symptoms.
3. A client with sickle cell crisis is experiencing acute
chest pain and shortness of breath. What is the
priority nursing intervention?
a. Administer oral fluids
b. Apply oxygen and prepare for possible exchange
transfusion
c. Encourage ambulation
d. Place the client in a Trendelenburg position
Correct Answer: b. Apply oxygen and prepare for
possible exchange transfusion
Rationale: Acute chest syndrome is a life-
threatening complication of sickle cell disease
characterized by pulmonary infiltrates and
hypoxia. The priority is to administer supplemental
oxygen and prepare for exchange transfusion to
reduce sickle hemoglobin concentration and
improve oxygenation.
, 4. The nurse is reviewing laboratory results for a
client with chronic kidney disease. Which finding is
most indicative of anemia of chronic disease?
a. Low serum erythropoietin level
b. Elevated mean corpuscular volume
c. High serum iron level
d. Decreased total iron-binding capacity
Correct Answer: a. Low serum erythropoietin level
Rationale: In chronic kidney disease, the kidneys
fail to produce adequate erythropoietin, which is
essential for stimulating red blood cell production
in the bone marrow. This results in a normocytic,
normochromic anemia that is responsive to
exogenous erythropoietin therapy.
5. A client diagnosed with hemophilia A is admitted
after a minor injury. Which medication order should
the nurse question?
a. Acetaminophen
b. Aspirin
c. Desmopressin
d. Factor VIII concentrate
Correct Answer: b. Aspirin
