ASCP Hematology Review verified questions and answers A+
Grade
Name the locations of active marrow in adults:
- correct answer sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation?
- correct answer yolk sac
Where does the majority of hematopoiesis take place during the 2nd through 7th month of gestation?
- correct answer spleen
When does the bone marrow take over hematopoiesis?
- correct answer after birth
What are the stages in order of the erythrocyte lineage?
- correct answer (1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte, (5)reticulocyte,
(6)erytrocyte
What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage?
- correct answer (1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band,
(6)segmented (7)eos/baso
What are the stages in order of the macrophage lineage?
- correct answer (1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
What are the stages in order of the platelet lineage?
- correct answer (1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte, (4)platelet
,What are the stages in order of the lymphocyte lineage?
- correct answer (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
Which growth factors stimulate the erythrocyte lineage?
- correct answer GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages?
- correct answer GM-CSF, IL-3
Which growth factors stimulate the platelet lineage?
- correct answer GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage?
- correct answer IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe?
- correct answer transferrin
What is the major storage form of Fe?
- correct answer ferritin
What is the long-term (H20) insoluble Fe storage form called?
- correct answer hemosiderin
Excess Iron is stored where? What does this cause?
- correct answer tissues and body organs, hemosiderosis, hemochromatosis
Porphyrias are attributed to?
- correct answer excessive formation of porphrins due to blockages in any enzymatic step in the heme
synthesis pathway.
, Red or port wine colored urine can be seen in which condition related to the build up of heme
precursors?
- correct answer porphyria
Neuropsychiatirc symptoms are seen when a build up of which precursors occurs?
- correct answer early precursors (Delta-aminolevulinic acid/Porphobilinogen)
Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a build up of which
precursors occurs?
- correct answer later precursors (uroporphyrinogen/coproporphyrinogen, protoporphyrin/heme)
Synthesis of heme requires what two components?
- correct answer iron, protoporphyrin
What are the heme precursors in order of synthesis?
- correct answer (1)delta-aminolevulinic acid, (2)porphobilinogen, (3)uroporphyrinogen,
(4)coproporphyrinogen, (5)protoporphyrin, (6)heme
What type of hemoglobin is seen primarily in newborns?
- correct answer Hgb F
What type of hemoglobin is seen primarily in adults?
- correct answer Hgb A2
What type of hemoglobin is rarely seen in adults as well as newborns?
- correct answer Hgb A
What hemoglobin types are seen in embryos but not in adults or newborns?
- correct answer gower I, gower II, portland
All non-embryonic hemoglobin types are comprised of what type of globin chain?
- correct answer alpha
Grade
Name the locations of active marrow in adults:
- correct answer sternum, skull, ribs, pelvis, vertebrae
Where does hematopoiesis take place during the first 2 months of gestation?
- correct answer yolk sac
Where does the majority of hematopoiesis take place during the 2nd through 7th month of gestation?
- correct answer spleen
When does the bone marrow take over hematopoiesis?
- correct answer after birth
What are the stages in order of the erythrocyte lineage?
- correct answer (1)rubriblast, (2)prorubricyte, (3)rubricyte, (4)metarubricyte, (5)reticulocyte,
(6)erytrocyte
What are the stages in order of the granulocyte (neutrophil, eosinophil, basophil) lineage?
- correct answer (1)myeloblast, (2)promyelocyte, (3)myelocyte, (4)metamyelocyte, (5)band,
(6)segmented (7)eos/baso
What are the stages in order of the macrophage lineage?
- correct answer (1)monoblast, (2)promonocyte, (3)monocyte, (4)macrophage
What are the stages in order of the platelet lineage?
- correct answer (1)megakaryoblast, (2)promegakaryocyte, (3)megakaryocyte, (4)platelet
,What are the stages in order of the lymphocyte lineage?
- correct answer (1)lymphoblast, (2)prolymphocyte, (3)lymphocyte
Which growth factors stimulate the erythrocyte lineage?
- correct answer GM-CSF, EPO, IL-3
Which growth factors stimulate the granulocyte lineages?
- correct answer GM-CSF, IL-3
Which growth factors stimulate the platelet lineage?
- correct answer GM-CSF, IL-3, TPO
Which growth factors stimulate the lymphocyte lineage?
- correct answer IL-2, IL-4, IL-6, IL-7
Which protein functions in the transport of Fe?
- correct answer transferrin
What is the major storage form of Fe?
- correct answer ferritin
What is the long-term (H20) insoluble Fe storage form called?
- correct answer hemosiderin
Excess Iron is stored where? What does this cause?
- correct answer tissues and body organs, hemosiderosis, hemochromatosis
Porphyrias are attributed to?
- correct answer excessive formation of porphrins due to blockages in any enzymatic step in the heme
synthesis pathway.
, Red or port wine colored urine can be seen in which condition related to the build up of heme
precursors?
- correct answer porphyria
Neuropsychiatirc symptoms are seen when a build up of which precursors occurs?
- correct answer early precursors (Delta-aminolevulinic acid/Porphobilinogen)
Cutaneous symptoms such as photo-sensitivity and facial hair are seen when a build up of which
precursors occurs?
- correct answer later precursors (uroporphyrinogen/coproporphyrinogen, protoporphyrin/heme)
Synthesis of heme requires what two components?
- correct answer iron, protoporphyrin
What are the heme precursors in order of synthesis?
- correct answer (1)delta-aminolevulinic acid, (2)porphobilinogen, (3)uroporphyrinogen,
(4)coproporphyrinogen, (5)protoporphyrin, (6)heme
What type of hemoglobin is seen primarily in newborns?
- correct answer Hgb F
What type of hemoglobin is seen primarily in adults?
- correct answer Hgb A2
What type of hemoglobin is rarely seen in adults as well as newborns?
- correct answer Hgb A
What hemoglobin types are seen in embryos but not in adults or newborns?
- correct answer gower I, gower II, portland
All non-embryonic hemoglobin types are comprised of what type of globin chain?
- correct answer alpha
