UAMS HEME LAB PRACTICAL 3
COMPREHENSIVE EXAM
QUESTIONS AND ANSWERS
GRADED A PLUS
◉ if VIII:vWF is deficient. Answer: Von Willebrand Disease
Factor VIII:C is also deficient, prolonged PTT
◉ What does VIII:vWF do. Answer: attaches collagen to glycoprotein
IB on platelet surface
◉ Difference between Hemophilia A and vWD. Answer: Hemophilia
A has normal bleeding time, Rist agg, vWFR:Co, and vWF:Ag
vWD is abnormal for all
◉ how is Hemophilia A inherited. Answer: recessive, X-linked
◉ How is vWD inherited. Answer: dominant, autosomal
◉ Platelet agg studies measure. Answer: primary and secondary
aggregation with various aggregates such as ADP
, ◉ What does an abnormal aggregation graph indicate. Answer:
platelet membrane defect
aspirin use
storage pool defect
◉ What agonist with an abnormal aggregation indicates vWD.
Answer: ristocetin
◉ Bernard Soulier disease. Answer: GPIb/IX/V complex is missing
on plt surface
◉ abnormal plt agg with bernard soulier disease. Answer: ristocetin
ristocetin and vWF
◉ Glanzmanns thrombasthenia. Answer: Defective plt membrane GP
IIb/IIIa
◉ abnormal plt agg with Glanzmanns. Answer: unable to find
fibrinogen
ADP
Collagen
Epinephrine
COMPREHENSIVE EXAM
QUESTIONS AND ANSWERS
GRADED A PLUS
◉ if VIII:vWF is deficient. Answer: Von Willebrand Disease
Factor VIII:C is also deficient, prolonged PTT
◉ What does VIII:vWF do. Answer: attaches collagen to glycoprotein
IB on platelet surface
◉ Difference between Hemophilia A and vWD. Answer: Hemophilia
A has normal bleeding time, Rist agg, vWFR:Co, and vWF:Ag
vWD is abnormal for all
◉ how is Hemophilia A inherited. Answer: recessive, X-linked
◉ How is vWD inherited. Answer: dominant, autosomal
◉ Platelet agg studies measure. Answer: primary and secondary
aggregation with various aggregates such as ADP
, ◉ What does an abnormal aggregation graph indicate. Answer:
platelet membrane defect
aspirin use
storage pool defect
◉ What agonist with an abnormal aggregation indicates vWD.
Answer: ristocetin
◉ Bernard Soulier disease. Answer: GPIb/IX/V complex is missing
on plt surface
◉ abnormal plt agg with bernard soulier disease. Answer: ristocetin
ristocetin and vWF
◉ Glanzmanns thrombasthenia. Answer: Defective plt membrane GP
IIb/IIIa
◉ abnormal plt agg with Glanzmanns. Answer: unable to find
fibrinogen
ADP
Collagen
Epinephrine