NURS 615 EXAM 1 COMPREHENSIVE
REVIEW SHEET VERIFIED QUESTION BANK
●● Criteria for choosing an effective drug for a disorder
Answer: Consulting nationally recognized guidelines for disease
management
●● Hypoalbuminemia affects the process of prescribing because
Answer: it increases the free drug floating around and could cause
toxicity or different effects
●● Hypoalbuminemia
Answer: affects the distribution of the drug to target tissue
●● Drugs with high first pass metabolism
Answer: are rapidly metabolized by the liver and may have little or if
any desired action.
Fraction of drug lost through the process of absorption.
●● First pass metabolism
Answer: The rapid uptake and metabolism of an active compound into
inactive compounds by the liver, immediately after enteric absorption
and before it reaches the systemic circulation.
,●● Half-life
Answer: the amount of time it takes for an administered drug to be half-
way cleared from the system
●● Loading dose
Answer: drugs with a long half life start with this to achieve desired
clinical effects more quickly.
Ex: azithromycin requires the first days dose to be twice that of the other
4 days
●● Onset of action
Answer: The point in time on the drug concentration curve that indicates
the first sign of a therapeutic effect
●● Peak of action
Answer: The time between drug administration and the maximum
concentration of a drug in the blood stream
●● Peak and trough levels
Answer: This is used to determine if a drug is in a therapeutic range
●● Steady-state
, Answer: Amount of drug needed in the body remains constant
●● IV administration
Answer: Does not involve absorption and there is no loss of the drug;
distribution throughout the body begins immediately
●● CYPs
Answer: are major enzymes that are involved in drug metabolism. They
account for nearly 75% of the total metabolism.
●● Drugs that utilize the CYP3A4 isoenzymes for metabolism
Answer: may induce the metabolism of another drug or inhibit the
metabolism of another drug
●● CYP450
Answer: is the reason behind drug interaction and the rationale of why
drugs affect different people in different ways
●● Grapefruit
Answer: reduces the clearance of simvastatin, increasing the risk of
myopathy
●● St. John's Wort
REVIEW SHEET VERIFIED QUESTION BANK
●● Criteria for choosing an effective drug for a disorder
Answer: Consulting nationally recognized guidelines for disease
management
●● Hypoalbuminemia affects the process of prescribing because
Answer: it increases the free drug floating around and could cause
toxicity or different effects
●● Hypoalbuminemia
Answer: affects the distribution of the drug to target tissue
●● Drugs with high first pass metabolism
Answer: are rapidly metabolized by the liver and may have little or if
any desired action.
Fraction of drug lost through the process of absorption.
●● First pass metabolism
Answer: The rapid uptake and metabolism of an active compound into
inactive compounds by the liver, immediately after enteric absorption
and before it reaches the systemic circulation.
,●● Half-life
Answer: the amount of time it takes for an administered drug to be half-
way cleared from the system
●● Loading dose
Answer: drugs with a long half life start with this to achieve desired
clinical effects more quickly.
Ex: azithromycin requires the first days dose to be twice that of the other
4 days
●● Onset of action
Answer: The point in time on the drug concentration curve that indicates
the first sign of a therapeutic effect
●● Peak of action
Answer: The time between drug administration and the maximum
concentration of a drug in the blood stream
●● Peak and trough levels
Answer: This is used to determine if a drug is in a therapeutic range
●● Steady-state
, Answer: Amount of drug needed in the body remains constant
●● IV administration
Answer: Does not involve absorption and there is no loss of the drug;
distribution throughout the body begins immediately
●● CYPs
Answer: are major enzymes that are involved in drug metabolism. They
account for nearly 75% of the total metabolism.
●● Drugs that utilize the CYP3A4 isoenzymes for metabolism
Answer: may induce the metabolism of another drug or inhibit the
metabolism of another drug
●● CYP450
Answer: is the reason behind drug interaction and the rationale of why
drugs affect different people in different ways
●● Grapefruit
Answer: reduces the clearance of simvastatin, increasing the risk of
myopathy
●● St. John's Wort
