RODAKS HEMATOLOGY 6TH EDITION
COMPREHENSIVE EXAM SCRIPT SOLVED
QUESTIONS GRADED A+
◉ Drug-induced antibodies
Answer: drugs stimulate the formation of an autoantibody that binds
to a specific platelet membrane glycoprotein with no requirement
for the presence of free drug. Gold salts, procainamide, and levodopa
are examples of such drugs
◉ Immune complex-induced thrombocytopenia
Answer: Heparin-induced thrombocytopenia (HIT) is a good
example of immune complex-induced thrombocytopenia
◉ Neonatal alloimmune thrombocytopenia (NAIT)
Answer: Develops when the mother lacks a platelet-specific antigen
that the fetus has inherited from the father
◉ Neonatal autoimmune thrombocytopenia
Answer: - Women commonly develop chronic ITP during pregnancy
which tends to remit after delivery
- Results from the passive transplacental transfer of maternal ITP
autoantibodies
, ◉ Nonimmune platelet destruction
Answer: may result from exposure of platelets to nonendothelial
surfaces, from activation of the coagulation process, or from platelet
consumption by endovascular injury without measurable depletion
of coagulation factors.
◉ Thrombocytosis
Answer: an abnormal increase in the number of platelets in the
circulating blood (>450,000/uL)
◉ Reactive Thrombocytosis
Answer: is used to describe an elevation in the platelet count
secondary to inflammation, trauma, or other underlying and
seemingly unrelated conditions
◉ Essential (primary) thrombocythemia
Answer: a chronic myeloproliferative neoplasm and is the most
common cause of thrombocytosis and is usually diagnosed by
excluding all the causes of reactive thrombocytosis.
◉ Hereditary Vascular Disorders
Answer: The following disorders are classified under?
COMPREHENSIVE EXAM SCRIPT SOLVED
QUESTIONS GRADED A+
◉ Drug-induced antibodies
Answer: drugs stimulate the formation of an autoantibody that binds
to a specific platelet membrane glycoprotein with no requirement
for the presence of free drug. Gold salts, procainamide, and levodopa
are examples of such drugs
◉ Immune complex-induced thrombocytopenia
Answer: Heparin-induced thrombocytopenia (HIT) is a good
example of immune complex-induced thrombocytopenia
◉ Neonatal alloimmune thrombocytopenia (NAIT)
Answer: Develops when the mother lacks a platelet-specific antigen
that the fetus has inherited from the father
◉ Neonatal autoimmune thrombocytopenia
Answer: - Women commonly develop chronic ITP during pregnancy
which tends to remit after delivery
- Results from the passive transplacental transfer of maternal ITP
autoantibodies
, ◉ Nonimmune platelet destruction
Answer: may result from exposure of platelets to nonendothelial
surfaces, from activation of the coagulation process, or from platelet
consumption by endovascular injury without measurable depletion
of coagulation factors.
◉ Thrombocytosis
Answer: an abnormal increase in the number of platelets in the
circulating blood (>450,000/uL)
◉ Reactive Thrombocytosis
Answer: is used to describe an elevation in the platelet count
secondary to inflammation, trauma, or other underlying and
seemingly unrelated conditions
◉ Essential (primary) thrombocythemia
Answer: a chronic myeloproliferative neoplasm and is the most
common cause of thrombocytosis and is usually diagnosed by
excluding all the causes of reactive thrombocytosis.
◉ Hereditary Vascular Disorders
Answer: The following disorders are classified under?
