BCHS 4311 Quiz 1 | Questions with 100% Verified Answers
| Latest Update
Question:
Beta-lactamase is reponsible for?
Answer:
Antibiotic resistance to beta-lactam antibiotics
Question:
How do beta-lactam antibiotics work? Provide an example
Answer:
They disrupt cell wall biosynthesis. The lactam ring mimics a peptidoglycan bridge and irreversibly
binds the transpeptidase, making it unavailable for peptidoglycan synthesis. Example: penicillin
Question:
What are the two sugars found in peptidoglycan and how do they work?
Answer:
NAG and NAM. They cross-link to strengthen bacteria cell walls and provide resistance against beta-
lactam antibiotics.
Question:
4 modes of drug resistance
Answer:
1. Penicillin-binding proteins (PBPs)
2. Efflux pumps
3. Fewer porins are required for beta-lactam uptake
4. Beta-lactamases
Question:
PBPs
Answer:
prevent transpeptidase from binding the penicillin by binding up the penicillins
Question:
Beta-lactamases Where do they bind?
Answer:
cleave penicillins; diffuse out of cell walls. Lactam ring *This is an issue
Question:
What is the function of clavulanic acid
, Answer:
inhibitors of beta-lactamase by irreversibly binding to it (suicide inhibitor)
Question:
What are beta-lactamase inhibitor proteins (BLIPs)
Answer:
bind beta-lactamase such that the BLIP interacts with the beta-lactamase active site.
Question:
How does the gene for beta-lactamase spread between species?
Answer:
through horizontal gene transfer mechanisms like conjugation, transformation, and transduction
Question:
Contirbuting causes of increasing antibiotic resistance:
Answer:
overuse commercial products livestock
Question:
Why Lac Operon?
Answer:
understanding gene expression.
Question:
Inducer
Answer:
a molecule that causes conformational change in a repressor leading to expression of the gene or
operon.
Question:
Repressor
Answer:
binds to the upstream regulatory region of a gene known as the operator and PREVENTS
TRANSCRIPTION.
Question:
Activator
Answer:
| Latest Update
Question:
Beta-lactamase is reponsible for?
Answer:
Antibiotic resistance to beta-lactam antibiotics
Question:
How do beta-lactam antibiotics work? Provide an example
Answer:
They disrupt cell wall biosynthesis. The lactam ring mimics a peptidoglycan bridge and irreversibly
binds the transpeptidase, making it unavailable for peptidoglycan synthesis. Example: penicillin
Question:
What are the two sugars found in peptidoglycan and how do they work?
Answer:
NAG and NAM. They cross-link to strengthen bacteria cell walls and provide resistance against beta-
lactam antibiotics.
Question:
4 modes of drug resistance
Answer:
1. Penicillin-binding proteins (PBPs)
2. Efflux pumps
3. Fewer porins are required for beta-lactam uptake
4. Beta-lactamases
Question:
PBPs
Answer:
prevent transpeptidase from binding the penicillin by binding up the penicillins
Question:
Beta-lactamases Where do they bind?
Answer:
cleave penicillins; diffuse out of cell walls. Lactam ring *This is an issue
Question:
What is the function of clavulanic acid
, Answer:
inhibitors of beta-lactamase by irreversibly binding to it (suicide inhibitor)
Question:
What are beta-lactamase inhibitor proteins (BLIPs)
Answer:
bind beta-lactamase such that the BLIP interacts with the beta-lactamase active site.
Question:
How does the gene for beta-lactamase spread between species?
Answer:
through horizontal gene transfer mechanisms like conjugation, transformation, and transduction
Question:
Contirbuting causes of increasing antibiotic resistance:
Answer:
overuse commercial products livestock
Question:
Why Lac Operon?
Answer:
understanding gene expression.
Question:
Inducer
Answer:
a molecule that causes conformational change in a repressor leading to expression of the gene or
operon.
Question:
Repressor
Answer:
binds to the upstream regulatory region of a gene known as the operator and PREVENTS
TRANSCRIPTION.
Question:
Activator
Answer:
