Immunity and Hematoligic Disorders
NSG 5003 Week 2
Innate immunity - answerImmunity that is present before exposure and effective from
birth. Responds to a broad range of pathogens.
adaptive immunity - answer immunity or resistance to a specific pathogen; slower to
respond, has memory component
Antigens - answerforeign substances that trigger the attack of antibodies in the immune
response.
antibody - answera substance produced by the body that destroys or inactivates an
antigen that has entered the body
Thymus - answerGland in the thoracic cavity above the heart where T lymphocytes
mature.
Basophils - answerA circulating leukocyte that produces histamine. Binds IgE Ex.
anaphylaxis
Neutrophils - answerMost abundant white blood cell., The most abundant type of white
blood cell. Phagocytic and tend to self-destruct as they destroy foreign invaders, limiting
their life span to a few days. First to attack infection
Eosinophils - answera white blood cell containing granules that are readily stained by
eosin. WBC involved in allergic reactions and parsitic infections.
Monocytes - answer*A type of white blood cell that transforms into macrophages,
extends pseudopods, and engulfs huge numbers of microbes over a long period of time
*An agranular leukocyte that is able to migrate into tissues and transform into a
macrophage.
B cells - answerCells manufactured in the bone marrow that create antibodies for
isolating and destroying invading bacteria and viruses. Prevents reinfection, immediate
inflammatory response
memory b cells function - answercirculate the body, proliferate, and response quickly
(via antibody synthesis) to eliminate subsequent invasion by same antigen. (2ndary
response - takes less time, ~5 days)
plasma cells - answerCells that develop from B cells and produce antibodies.
, T cells - answerCells created in the thymus that produce substances that attack infected
cells in the body.
Killer T cells - answerLymphocytes that use enzymes to destroy the cell membranes of
bacteria and other foreign invaders.
Helper T cells - answerActivate macrophages, B cells and T cells.
innate immunity - answerPhysical and chemical barriers that protect against all invaders
*skin/dermis #1 barrier, mucosa, chemical
inflammatory response - answernonspecific defense reaction to tissue damage caused
by injury or infection and can begin shortly after injury and can last hours to days
vascular response - answer-facilitated by chemical mediators
-induces vasodilation and increases capillary permeability
-objective is to get more blood flowing to the injured area
* erythema, edema, heat, pain
mast cells - answerCells that release chemicals (such as histamine) that promote
inflammation.
Leukotrienes - answermediator of mast cells, causes vasodilation and increases
vascular permability
Cytokines - answerproteins secreted by cytotoxic T cells to aid in antigen destruction by
antibody devlopment and wbc recruitment
Prostaglandins - answerinhibit platelet aggregation causes pain, bronchoconstriction,
and increased vascular permability
Heparin - answerpromotes new blood vessel growth, anticoagulant
Interferons - answersmall proteins released from infected cells by viruses and stop the
spread of virus to new cells.
Cellular Immunity (T cells) - answerCell mediated immunity, cells target virus infected
cell
humoral immunity - answerspecific immunity produced by B cells that produce
antibodies that circulate in body fluids
IgG - answercrosses placenta, main defense against bacteria. Passive immunity
IgM - answerfirst antibody made by the fetus, fights blood infections
NSG 5003 Week 2
Innate immunity - answerImmunity that is present before exposure and effective from
birth. Responds to a broad range of pathogens.
adaptive immunity - answer immunity or resistance to a specific pathogen; slower to
respond, has memory component
Antigens - answerforeign substances that trigger the attack of antibodies in the immune
response.
antibody - answera substance produced by the body that destroys or inactivates an
antigen that has entered the body
Thymus - answerGland in the thoracic cavity above the heart where T lymphocytes
mature.
Basophils - answerA circulating leukocyte that produces histamine. Binds IgE Ex.
anaphylaxis
Neutrophils - answerMost abundant white blood cell., The most abundant type of white
blood cell. Phagocytic and tend to self-destruct as they destroy foreign invaders, limiting
their life span to a few days. First to attack infection
Eosinophils - answera white blood cell containing granules that are readily stained by
eosin. WBC involved in allergic reactions and parsitic infections.
Monocytes - answer*A type of white blood cell that transforms into macrophages,
extends pseudopods, and engulfs huge numbers of microbes over a long period of time
*An agranular leukocyte that is able to migrate into tissues and transform into a
macrophage.
B cells - answerCells manufactured in the bone marrow that create antibodies for
isolating and destroying invading bacteria and viruses. Prevents reinfection, immediate
inflammatory response
memory b cells function - answercirculate the body, proliferate, and response quickly
(via antibody synthesis) to eliminate subsequent invasion by same antigen. (2ndary
response - takes less time, ~5 days)
plasma cells - answerCells that develop from B cells and produce antibodies.
, T cells - answerCells created in the thymus that produce substances that attack infected
cells in the body.
Killer T cells - answerLymphocytes that use enzymes to destroy the cell membranes of
bacteria and other foreign invaders.
Helper T cells - answerActivate macrophages, B cells and T cells.
innate immunity - answerPhysical and chemical barriers that protect against all invaders
*skin/dermis #1 barrier, mucosa, chemical
inflammatory response - answernonspecific defense reaction to tissue damage caused
by injury or infection and can begin shortly after injury and can last hours to days
vascular response - answer-facilitated by chemical mediators
-induces vasodilation and increases capillary permeability
-objective is to get more blood flowing to the injured area
* erythema, edema, heat, pain
mast cells - answerCells that release chemicals (such as histamine) that promote
inflammation.
Leukotrienes - answermediator of mast cells, causes vasodilation and increases
vascular permability
Cytokines - answerproteins secreted by cytotoxic T cells to aid in antigen destruction by
antibody devlopment and wbc recruitment
Prostaglandins - answerinhibit platelet aggregation causes pain, bronchoconstriction,
and increased vascular permability
Heparin - answerpromotes new blood vessel growth, anticoagulant
Interferons - answersmall proteins released from infected cells by viruses and stop the
spread of virus to new cells.
Cellular Immunity (T cells) - answerCell mediated immunity, cells target virus infected
cell
humoral immunity - answerspecific immunity produced by B cells that produce
antibodies that circulate in body fluids
IgG - answercrosses placenta, main defense against bacteria. Passive immunity
IgM - answerfirst antibody made by the fetus, fights blood infections
