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1. If a patient is experiencing severe extrapyramidal symptoms while on a typical
antipsychotic, how might switching to an atypical antipsychotic that targets
the 5HT2A receptor help?
It will increase the severity of the symptoms.
It will have no effect on the symptoms.
It will only address mood-related symptoms.
It may reduce the extrapyramidal symptoms due to the receptor's
antagonism.
2. Describe the significance of avoiding strong CYP3A4 inducers when
prescribing Lurasidone.
Strong CYP3A4 inducers have no impact on Lurasidone's
effectiveness.
Strong CYP3A4 inducers enhance the effects of Lurasidone, leading
to increased side effects.
Strong CYP3A4 inducers can decrease the effectiveness of
Lurasidone by increasing its metabolism.
Strong CYP3A4 inducers are used to treat the side effects of
Lurasidone.
3. Describe the implications of the black box warning for patients prescribed
deutetrabenazine (Austedo).
Patients can stop taking the medication if they experience side effects.
Patients should increase their dosage if they feel depressed.
, Patients prescribed deutetrabenazine should be monitored for
signs of depression and suicidal thoughts.
Patients do not need any special monitoring while on this medication.
4. Serotonin (5HT) is a neurotransmitter associated with mood, sleep, and
psychosis. There are several serotonin receptors all over the human body. A
unique aspect of the second generation antipsychotics is their ability to block
5HT2a receptors. What is the effect of this inhibition?
Induces anxiety
Stabilizes dopamine concentrations in the CNS
Causes hallucinations
Reduces platelet function
5. Which antipsychotic medications are included in the 'Pines' category?
Haloperidol and Chlorpromazine
Ziprasidone and Lurasidone
Risperidone and Aripiprazole
Olanzapine and Quetiapine
6. Which group of atypical antipsychotics would be expected to have the
lowest risk of EPS and highest risk of wt gain and sedation
dones
pips/rip
pines
7. Describe the impact of D2 receptor blockade on the nigrostriatal pathway
and its potential consequences.
, D2 receptor blockade increases serotonin levels, reducing motor side
effects.
D2 receptor blockade decreases dopamine release, leading to
improved motor function.
D2 receptor blockade has no effect on dopamine levels in the
nigrostriatal pathway.
D2 receptor blockade leads to increased dopamine release as a
compensatory mechanism, which can result in motor side effects.
8. Describe how 5HT1A antagonists influence neurotransmitter systems in the
brain.
5HT1A antagonists only affect glutamate levels in the brain.
5HT1A antagonists inhibit norepinephrine release, reducing anxiety.
5HT1A antagonists enhance dopamine activity, leading to improved
mood.
5HT1A antagonists block serotonin receptors, which can lead to
increased serotonin release and modulation of mood.
9. A nurse is providing education to a client on Haloperidol. The client
expresses a concern about their blood pressure. What should the nurse
educate the client on?
Haloperidol can raise your blood pressure. You should take your
blood pressure daily.
This medication lowers blood pressure. You should skip taking it for
the day if you notice your blood pressure is low
A possible side effect is hypotension. You should avoid any sudden
movements.
, This medication increases your blood pressure. You may need to take
an antihypertensive.
10. 5HT2C antagonism in SSRIs leads to what effect?
Increased NE and DA
Weight gain and hunger
Sexual dysfunction
Hyponatremia
11. If a patient is experiencing severe agitation and requires sedation, how might
Haloperidol be utilized in their treatment plan?
Haloperidol can be administered to provide rapid sedation due to
its sedative properties.
Haloperidol should be avoided as it can worsen agitation.
Haloperidol is ineffective in managing agitation.
Haloperidol is used only for long-term management of psychosis.
12. Which antipsychotic therapy is metabolized by CYP3A4 and is CI w/inducer
or inhibitor?
Olanzapine (Zyprexa)
Aeipiprazole (Abilify)
Quetiapine (Seroquel)
Risperidone (Risperdal)
Lurasidone (Latuda)
Ziprasidone (Geodon)