Immunology Kuby - Exam 2 Questions
With Correct Answers
If a B cell has a non-productive rearrangement at the first K light chain
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allele, what will happen next? - CORRECT ANSWER✔✔-Rearrangement
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will begin at the second K light chain allele
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At which stage during T cell development does cell commitment to the T
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cell lineage occur? - CORRECT ANSWER✔✔-DN
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Which of the following is the correct order of T cell development? -
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CORRECT ANSWER✔✔-HSC-CLP-DN-SP-Mature T cell
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Deficiency in RAG-1 and/or RAG-2 can affect the proper development of
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which of the following cell types, resulting in decreased numbers of
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circulating cells of those types? - CORRECT ANSWER✔✔-Both A and B
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B cell development has a checkpoint to determine VhDJh
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rearrangement has produced a successful combination that can interact | | | | | | | | |
with a surrogate light chain. At what point of B cell development does
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this checkpoint occur? - CORRECT ANSWER✔✔-Between pro-B and pre-
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B
, In people infected with human cytomegalovirus, class I MHC and B2-
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microglobulin are produced, but very little mature class I MHC | | | | | | | | | |
complexed with viral antigen is found at the cell surface. Inhibition of
| | | | | | | | | | | |
which of the following molecules by human cytomegalovirus may
| | | | | | | | |
explain this phenomenon? - CORRECT ANSWER✔✔-TAP
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The pre-BCR is made up of: - CORRECT ANSWER✔✔-A completed
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functional heavy chain and a surrogate light chain
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The spacer sequence of a recombination signal sequence (RSS) is
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composed of how many base pairs - CORRECT ANSWER✔✔-12 or 23
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Which of the following TCR gene regions possesses a "D" segment? -
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CORRECT ANSWER✔✔-Both A and C | | | |
Transition from a pro-B cell to a pre-B cell requires interaction of the cell
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with: - CORRECT ANSWER✔✔-IL-7
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Several proteins must work in a coordinating fashion to achieve V(D)J
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recombination. Which is responsible for adding non-templated | | | | | | |
nucleotides to the V-D and D-J joints of Ig heavy chains? - CORRECT
| | | | | | | | | | | | |
ANSWER✔✔-TdT
With Correct Answers
If a B cell has a non-productive rearrangement at the first K light chain
| | | | | | | | | | | | | |
allele, what will happen next? - CORRECT ANSWER✔✔-Rearrangement
| | | | | | | |
will begin at the second K light chain allele
| | | | | | | |
At which stage during T cell development does cell commitment to the T
| | | | | | | | | | | |
cell lineage occur? - CORRECT ANSWER✔✔-DN
| | | | | |
Which of the following is the correct order of T cell development? -
| | | | | | | | | | | | |
CORRECT ANSWER✔✔-HSC-CLP-DN-SP-Mature T cell
| | |
Deficiency in RAG-1 and/or RAG-2 can affect the proper development of
| | | | | | | | | | |
which of the following cell types, resulting in decreased numbers of
| | | | | | | | | | |
circulating cells of those types? - CORRECT ANSWER✔✔-Both A and B
| | | | | | | | | |
B cell development has a checkpoint to determine VhDJh
| | | | | | | | |
rearrangement has produced a successful combination that can interact | | | | | | | | |
with a surrogate light chain. At what point of B cell development does
| | | | | | | | | | | | |
this checkpoint occur? - CORRECT ANSWER✔✔-Between pro-B and pre-
| | | | | | | |
B
, In people infected with human cytomegalovirus, class I MHC and B2-
| | | | | | | | | |
microglobulin are produced, but very little mature class I MHC | | | | | | | | | |
complexed with viral antigen is found at the cell surface. Inhibition of
| | | | | | | | | | | |
which of the following molecules by human cytomegalovirus may
| | | | | | | | |
explain this phenomenon? - CORRECT ANSWER✔✔-TAP
| | | | |
The pre-BCR is made up of: - CORRECT ANSWER✔✔-A completed
| | | | | | | | | |
functional heavy chain and a surrogate light chain
| | | | | | |
The spacer sequence of a recombination signal sequence (RSS) is
| | | | | | | | | |
composed of how many base pairs - CORRECT ANSWER✔✔-12 or 23
| | | | | | | | | |
Which of the following TCR gene regions possesses a "D" segment? -
| | | | | | | | | | | |
CORRECT ANSWER✔✔-Both A and C | | | |
Transition from a pro-B cell to a pre-B cell requires interaction of the cell
| | | | | | | | | | | | |
with: - CORRECT ANSWER✔✔-IL-7
| | | |
Several proteins must work in a coordinating fashion to achieve V(D)J
| | | | | | | | | | |
recombination. Which is responsible for adding non-templated | | | | | | |
nucleotides to the V-D and D-J joints of Ig heavy chains? - CORRECT
| | | | | | | | | | | | |
ANSWER✔✔-TdT
