ONS Chemotherapy Immunotherapy
Certificate Exam Questions and
Answers
1. 3 major phases of cell division::
Interphase Mitotic phase
Cytokinesis
2. 3 steps of interphase:: First growth
phase (G1) Synthesis phase (S phase)
Second growth phase (G2)
3. 4 phases of mitosis::
Prophase Metaphase
Anaphase
Telophase
4. Innate immunity:: Non-specific response, either:
1. Barrier (skin, mucous membranes, flora of skin/gut)
2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages)
5. Adaptive immunity:: Follows innate immunity if unsuccessful. Memory immunity,
, including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon T cells)
3. Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses)
6. Define mutations: Variations in the nucleotide sequence of a gene
7. 3 main goals of treatment::
Cure Control
Palliation
8. Define neoadjuvant therapy: Treatment is given prior to surgery to shrink the tumor
9. Define adjuvant therapy: Additional cancer treatment given after the primary treatment
to lower the risk that the cancer reoccur
10. Define conditioning/preparative therapy: Treatments used to prepare a
patient for stem cell transplantation
11. 2 types of conditioning therapies::
Myeloablative Nonmyeloablative
12. Define dose density: Drug dose per unit of time
, 13. Define dose intensity: Amount of drug delivered over time
14. How is relative dose intensity (RDI) calculated?: By comparing the dose
that the patient ACTUALLY received to the planned dose of the standard regimen
15. How do alkylating agents work?: By causing a break in the DNA helix strand,
interfering with DNA replication and causing cell death
16. 3 subcategories of alkylating agents:: 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work
similarly)
3. Nitrosoureas
17. Most common subcategory of alkylating agents:: Nitrogen
mustards
18. Common alkylating agents::
Cyclophosphamide (Cytoxan) Ifosfamide (Ifex)
Bendamustine (Treanda)
19. Common platinum-based agents::
Cisplatin (Platinol) Carboplatin (Paraplatin)
Certificate Exam Questions and
Answers
1. 3 major phases of cell division::
Interphase Mitotic phase
Cytokinesis
2. 3 steps of interphase:: First growth
phase (G1) Synthesis phase (S phase)
Second growth phase (G2)
3. 4 phases of mitosis::
Prophase Metaphase
Anaphase
Telophase
4. Innate immunity:: Non-specific response, either:
1. Barrier (skin, mucous membranes, flora of skin/gut)
2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages)
5. Adaptive immunity:: Follows innate immunity if unsuccessful. Memory immunity,
, including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon T cells)
3. Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses)
6. Define mutations: Variations in the nucleotide sequence of a gene
7. 3 main goals of treatment::
Cure Control
Palliation
8. Define neoadjuvant therapy: Treatment is given prior to surgery to shrink the tumor
9. Define adjuvant therapy: Additional cancer treatment given after the primary treatment
to lower the risk that the cancer reoccur
10. Define conditioning/preparative therapy: Treatments used to prepare a
patient for stem cell transplantation
11. 2 types of conditioning therapies::
Myeloablative Nonmyeloablative
12. Define dose density: Drug dose per unit of time
, 13. Define dose intensity: Amount of drug delivered over time
14. How is relative dose intensity (RDI) calculated?: By comparing the dose
that the patient ACTUALLY received to the planned dose of the standard regimen
15. How do alkylating agents work?: By causing a break in the DNA helix strand,
interfering with DNA replication and causing cell death
16. 3 subcategories of alkylating agents:: 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work
similarly)
3. Nitrosoureas
17. Most common subcategory of alkylating agents:: Nitrogen
mustards
18. Common alkylating agents::
Cyclophosphamide (Cytoxan) Ifosfamide (Ifex)
Bendamustine (Treanda)
19. Common platinum-based agents::
Cisplatin (Platinol) Carboplatin (Paraplatin)
