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PRACTITIONER BOARD REVIEW
FITZ EXIT EXAM — 2026/2027 EDITION
Comprehensive Nurse Practitioner Board-Review Practice Examination
Course Code: FITZ Exit Exam
Course Name: Nurse Practitioner Comprehensive Board Review
Institution: Chamberlain University
Academic Year: 2026/2027
Date: August 11, 2026
Content Type: Comprehensive practice examination with answers and detailed
rationales
COVER PAGE
FITZ EXIT EXAM
2026/2027 EDITION
Comprehensive Nurse Practitioner Board-Review Practice Examination
Institution: Chamberlain University
Course: Nurse Practitioner Comprehensive Board Review
Academic Year: 2026/2027
Total Questions: 100
Question Types: Multiple Choice and Short Answer
Includes: Correct Answers and Clinical Rationales
Educational Notice
This is an original practice examination designed for nurse-practitioner review.
Clinical recommendations can change. Learners should compare this material with current
course resources, institutional policies, and current evidence-based clinical guidelines.
TABLE OF CONTENTS
1. Cardiovascular System — Questions 1–10
, 2. Respiratory System — Questions 11–17
3. Gastrointestinal System — Questions 18–24
4. Endocrine System — Questions 25–31
5. Renal and Genitourinary System — Questions 32–38
6. Neurologic System — Questions 39–45
7. Musculoskeletal and Rheumatologic System — Questions 46–51
8. Dermatologic System — Questions 52–56
9. Hematologic and Oncologic System — Questions 57–61
10. Infectious Disease — Questions 62–67
11. Women's Health — Questions 68–73
12. Men's Health — Questions 74–77
13. Pediatrics — Questions 78–82
14. Geriatrics — Questions 83–86
15. Mental Health — Questions 87–91
16. Preventive Care and Health Promotion — Questions 92–94
17. Pharmacology — Questions 95–97
18. Emergency and Acute Care — Questions 98–100
SECTION 1 — CARDIOVASCULAR SYSTEM
Question 1 — Multiple Choice
A 64-year-old patient develops substernal chest pressure while walking. The discomfort radiates
to the left arm and is accompanied by diaphoresis and nausea. What diagnosis should receive the
highest priority?
A. Gastroesophageal reflux disease
B. Acute coronary syndrome
C. Costochondritis
D. Panic disorder
Correct Answer: B. Acute coronary syndrome
,Rationale:
Exertional substernal pressure with radiation and autonomic symptoms such as diaphoresis and
nausea is highly concerning for myocardial ischemia. Acute coronary syndrome must be
evaluated urgently. Although reflux, musculoskeletal pain, and anxiety can cause chest
symptoms, the described presentation has a classic ischemic pattern.
Question 2 — Multiple Choice
Which finding is most characteristic of left-sided heart failure?
A. Ascites
B. Hepatomegaly
C. Pulmonary crackles
D. Peripheral venous stasis
Correct Answer: C. Pulmonary crackles
Rationale:
Left ventricular dysfunction increases pulmonary venous pressure, causing pulmonary
congestion and potentially crackles. Right-sided failure more commonly produces systemic
venous congestion, including peripheral edema, hepatomegaly, and ascites.
Question 3 — Short Answer
What is the principal hemodynamic abnormality contributing to most cases of essential
hypertension?
Correct Answer: Increased systemic vascular resistance.
Rationale:
Essential hypertension is multifactorial and involves genetic, renal, neurohormonal, vascular, and
environmental factors. Increased systemic vascular resistance is a major determinant of elevated
blood pressure. Abnormal sodium handling and activation of the sympathetic and renin-
angiotensin-aldosterone systems can contribute.
Question 4 — Multiple Choice
A patient has an irregularly irregular pulse. Which cardiac rhythm is most likely?
A. Atrial fibrillation
B. Atrial flutter with fixed conduction
, C. First-degree AV block
D. Sinus bradycardia
Correct Answer: A. Atrial fibrillation
Rationale:
Atrial fibrillation produces chaotic atrial electrical activity and variable AV conduction, resulting
in an irregularly irregular ventricular rhythm. Atrial flutter often has organized atrial activity and
may produce a regular ventricular response when conduction is fixed.
Question 5 — Multiple Choice
Which symptom is particularly concerning in a patient with significant aortic stenosis?
A. Exertional syncope
B. Mild ankle swelling
C. Nasal congestion
D. Occasional heartburn
Correct Answer: A. Exertional syncope
Rationale:
Classic symptomatic aortic stenosis includes exertional dyspnea, angina, and syncope. Exertional
syncope can result from the inability to adequately increase cardiac output across a severely
narrowed aortic valve.
Question 6 — Multiple Choice
Which medication class is commonly used as first-line therapy for hypertension in appropriate
patients?
A. Thiazide-type diuretics
B. Opioids
C. Proton-pump inhibitors
D. Anticholinergic agents
Correct Answer: A. Thiazide-type diuretics
Rationale:
Thiazide-type diuretics are among the major evidence-supported first-line antihypertensive
classes, along with ACE inhibitors, ARBs, and calcium-channel blockers. Choice should be
individualized based on comorbidities, contraindications, and patient factors.