CARN AP UPDATED SET QUESTIONS AND ANSWERS
SET A+
✔✔Korsokoff's Syndrome- an alcohol related disorder marked by extreme ________
and _______ impairment
________ is a fundamental neuropsychiatric symptom of the disorder - ✔✔confusion
memory
apathy
✔✔To start methadone treatment, the patient must be on opioids for at least ___
months, unless what? - ✔✔12
Pregnancy is an exception to this criteria, even if the use of opioids is less than a year.
✔✔What is the maximum dose of methadone for the worst withdrawal symptoms?
What is the initial dosage for everyone else (i.e. used by most clinics) - ✔✔40 mg
30 mg
✔✔In the liver, an enzyme called ________ __________ converts alcohol to
what__________ - ✔✔alcohol dehydrogenase (ADH)
acetaldehyde.
✔✔ALDH converts acetaldehyde to - ✔✔Acetate
✔✔Elevated ________ cause increased flushing, tachycardia, n/v & hyperventilation. -
✔✔acetaldehyde
✔✔What are the 3 MAT for AUD
What are 2 off label MAT? - ✔✔Disulfiram
,Acomporstate
Naltrexone
Gabapentin & Topiramate
✔✔Disulfiram (________)
Discourages drinking by:
Must be taken at least _____ hours after their las drink to minimize the reaction will
occur - ✔✔Antabuse
making the patient physically ill when alcohol is consumed
12
✔✔Individuals must be highly motivated to take ________ - ✔✔Disulfiram
✔✔What 3 drug substances are approved by the FDA for MAT? - ✔✔Alcohol, Opioid,
Nicotine
✔✔A 57-year-old man with a longstanding history of alcohol use presents with
confusion, disorientation, and gait imbalance. Other than disorientation, bilateral paresis
of conjugate gaze is noted. CT head is negative. Which vitamin deficiency is most
likely? - ✔✔Thiamine (B1)
✔✔What medication used in AUD inhibits ALDH? - ✔✔Disulfiram
✔✔Disulfiram action causes an excess of what enzyme?
This enzyme has a vasodilatory effect that causes: - ✔✔Acetaldehyde
tachycardia and hypotension.
✔✔4 NTs associated with drinking are - ✔✔Glutamate
GABA
Dopamine
Endogenous opioids
✔✔When alcohol is consumed there is a release of
___________ ________, then _______ ,which makes the drinker feel good.
AT THE SAME TIME
alcohol has an effect on ______ receptors; they are are increased (sedation effect)
OVERTIME
, the brain responds to an excess and increase of alcohol by upregulating ________
receptors to compensate for the increase in GABA - ✔✔endogenous opioids
dopamine
GABA
glutamate
✔✔Alcohol withdrawal symptoms will occur when there is excess ________ activity in
relevance to GABA - ✔✔glutamate
✔✔Minor alcohol withdrawal occurs within _______ after their last drink - ✔✔36
✔✔Disulfiram has a _____ half life; reaction could occur 1-2 weeks after last dose -
✔✔long
✔✔Acamprosate is a _______ receptor modulator
Dosage: 2x333mg PO tab TID
Indication: - ✔✔glutamate
Those individuals who are abstinent from alcohol at initiation of treatment
✔✔Naltrexone is an opioid receptor _______ - ✔✔antagonist
✔✔_____ is the most suitable drug for patients with mild opioid use disorder. -
✔✔Naltrexone
✔✔Naltrexone is the most suitable drug for patients with _____ opioid use disorder. -
✔✔mild
✔✔Which AUD drug will cause opioid withdrawal symptoms in patients who are
physically dependent on opioids?
Person must not had taken long acting opioids how many days prior to starting?
Person must not had taken short acting opioids how many days prior to starting?
Confirm abstinence with what 2 things?: - ✔✔Naltrexone
10-14 day
atleast7
Urine drug test & Naltrexone Challenge
SET A+
✔✔Korsokoff's Syndrome- an alcohol related disorder marked by extreme ________
and _______ impairment
________ is a fundamental neuropsychiatric symptom of the disorder - ✔✔confusion
memory
apathy
✔✔To start methadone treatment, the patient must be on opioids for at least ___
months, unless what? - ✔✔12
Pregnancy is an exception to this criteria, even if the use of opioids is less than a year.
✔✔What is the maximum dose of methadone for the worst withdrawal symptoms?
What is the initial dosage for everyone else (i.e. used by most clinics) - ✔✔40 mg
30 mg
✔✔In the liver, an enzyme called ________ __________ converts alcohol to
what__________ - ✔✔alcohol dehydrogenase (ADH)
acetaldehyde.
✔✔ALDH converts acetaldehyde to - ✔✔Acetate
✔✔Elevated ________ cause increased flushing, tachycardia, n/v & hyperventilation. -
✔✔acetaldehyde
✔✔What are the 3 MAT for AUD
What are 2 off label MAT? - ✔✔Disulfiram
,Acomporstate
Naltrexone
Gabapentin & Topiramate
✔✔Disulfiram (________)
Discourages drinking by:
Must be taken at least _____ hours after their las drink to minimize the reaction will
occur - ✔✔Antabuse
making the patient physically ill when alcohol is consumed
12
✔✔Individuals must be highly motivated to take ________ - ✔✔Disulfiram
✔✔What 3 drug substances are approved by the FDA for MAT? - ✔✔Alcohol, Opioid,
Nicotine
✔✔A 57-year-old man with a longstanding history of alcohol use presents with
confusion, disorientation, and gait imbalance. Other than disorientation, bilateral paresis
of conjugate gaze is noted. CT head is negative. Which vitamin deficiency is most
likely? - ✔✔Thiamine (B1)
✔✔What medication used in AUD inhibits ALDH? - ✔✔Disulfiram
✔✔Disulfiram action causes an excess of what enzyme?
This enzyme has a vasodilatory effect that causes: - ✔✔Acetaldehyde
tachycardia and hypotension.
✔✔4 NTs associated with drinking are - ✔✔Glutamate
GABA
Dopamine
Endogenous opioids
✔✔When alcohol is consumed there is a release of
___________ ________, then _______ ,which makes the drinker feel good.
AT THE SAME TIME
alcohol has an effect on ______ receptors; they are are increased (sedation effect)
OVERTIME
, the brain responds to an excess and increase of alcohol by upregulating ________
receptors to compensate for the increase in GABA - ✔✔endogenous opioids
dopamine
GABA
glutamate
✔✔Alcohol withdrawal symptoms will occur when there is excess ________ activity in
relevance to GABA - ✔✔glutamate
✔✔Minor alcohol withdrawal occurs within _______ after their last drink - ✔✔36
✔✔Disulfiram has a _____ half life; reaction could occur 1-2 weeks after last dose -
✔✔long
✔✔Acamprosate is a _______ receptor modulator
Dosage: 2x333mg PO tab TID
Indication: - ✔✔glutamate
Those individuals who are abstinent from alcohol at initiation of treatment
✔✔Naltrexone is an opioid receptor _______ - ✔✔antagonist
✔✔_____ is the most suitable drug for patients with mild opioid use disorder. -
✔✔Naltrexone
✔✔Naltrexone is the most suitable drug for patients with _____ opioid use disorder. -
✔✔mild
✔✔Which AUD drug will cause opioid withdrawal symptoms in patients who are
physically dependent on opioids?
Person must not had taken long acting opioids how many days prior to starting?
Person must not had taken short acting opioids how many days prior to starting?
Confirm abstinence with what 2 things?: - ✔✔Naltrexone
10-14 day
atleast7
Urine drug test & Naltrexone Challenge
