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ATI Infection Control Practice Exam Preparation
With Complete Questions And Correct Answers With
Rationales Already Graded A+ Brand New Version!!
Question 1
A nurse is caring for a client who has a suspected infection caused by a
multidrug-resistant organism (MDRO). Which action should the nurse
take first when entering the client's room?
A. Apply sterile gloves before touching the client.
B. Place the client in a positive-pressure isolation room.
C. Perform hand hygiene and don appropriate personal protective
equipment (PPE).
D. Wear an N95 respirator before entering the room.
Correct Answer: C
Rationale: Hand hygiene is the single most important infection
prevention measure and must be performed before applying any PPE.
The selection of PPE depends on the specific mode of transmission and
the type of precautions required for the suspected MDRO. Positive-
pressure rooms and N95 respirators are not routinely required for
MDRO infections; these are indicated for specific conditions such as
airborne precautions for tuberculosis. The nurse's first action upon
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entering any client's room should always be to perform hand hygiene
and then apply the appropriate PPE based on the transmission-based
precautions in place.
Question 2
A nurse is caring for a client with Clostridioides difficile infection. Which
intervention is appropriate?
A. Use alcohol-based hand sanitizer after client care.
B. Place the client under airborne precautions.
C. Clean equipment with a sporicidal disinfectant.
D. Use surgical masks when entering the room.
Correct Answer: C
Rationale: C. difficile forms spores that are highly resistant to alcohol-
based hand sanitizers. Therefore, soap and water handwashing must be
used, and environmental surfaces and equipment should be cleaned
with a sporicidal disinfectant (such as bleach-based products) to reduce
transmission. C. difficile requires contact precautions, not airborne
precautions. Surgical masks are not sufficient; gowns and gloves are
required for contact precautions.
Question 3
When providing care for a client who has Clostridium difficile, which of
the following hand hygiene methods is required?
A. Alcohol-based hand rub.
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B. Soap and water.
C. Hand sanitizer with 70% ethanol.
D. Warm water only.
Correct Answer: B
Rationale: Soap and water is required for C. difficile because alcohol-
based products, including hand sanitizers with ethanol, are ineffective
against the spores. The mechanical friction of washing with soap and
water is necessary to physically remove the spores from the hands.
Question 4
Which personal protective equipment (PPE) is essential when entering
the room of a client on Airborne Precautions for tuberculosis?
A. Surgical mask.
B. Face shield.
C. N95 respirator.
D. Gown and gloves only.
Correct Answer: C
Rationale: Airborne precautions require an N95 respirator (or higher-
level respirator) to filter out small droplet nuclei (≤5 microns) that
remain suspended in the air for extended periods. A surgical mask
provides only droplet protection and is insufficient for airborne
transmission. Gown and gloves may be required if contact with body
fluids is anticipated, but they do not provide respiratory protection.
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Question 5
In which order should a nurse remove personal protective equipment
(PPE) after completing a task?
A. Gloves, goggles, gown, mask.
B. Mask, goggles, gown, gloves.
C. Goggles, gown, mask, gloves.
D. Gown, mask, goggles, gloves.
Correct Answer: A
Rationale: The standard sequence for doffing (removing) PPE is gloves
first, followed by eyewear/goggles, then the gown, and finally the
mask/respirator. Gloves are considered the most contaminated PPE
item and should be removed first to reduce the risk of contaminating
other equipment and clothing. The mask or respirator is removed last,
typically after leaving the client's room or at the doorway.
Question 6
A nurse is preparing to suction a client with a tracheostomy. Which
action demonstrates correct infection control practice?
A. Reuse the suction catheter after rinsing it with sterile water.
B. Maintain sterile technique throughout the suctioning procedure.
C. Wear clean gloves instead of sterile gloves.
D. Disconnect the ventilator tubing before suctioning.
ATI Infection Control Practice Exam Preparation
With Complete Questions And Correct Answers With
Rationales Already Graded A+ Brand New Version!!
Question 1
A nurse is caring for a client who has a suspected infection caused by a
multidrug-resistant organism (MDRO). Which action should the nurse
take first when entering the client's room?
A. Apply sterile gloves before touching the client.
B. Place the client in a positive-pressure isolation room.
C. Perform hand hygiene and don appropriate personal protective
equipment (PPE).
D. Wear an N95 respirator before entering the room.
Correct Answer: C
Rationale: Hand hygiene is the single most important infection
prevention measure and must be performed before applying any PPE.
The selection of PPE depends on the specific mode of transmission and
the type of precautions required for the suspected MDRO. Positive-
pressure rooms and N95 respirators are not routinely required for
MDRO infections; these are indicated for specific conditions such as
airborne precautions for tuberculosis. The nurse's first action upon
,2|Page
entering any client's room should always be to perform hand hygiene
and then apply the appropriate PPE based on the transmission-based
precautions in place.
Question 2
A nurse is caring for a client with Clostridioides difficile infection. Which
intervention is appropriate?
A. Use alcohol-based hand sanitizer after client care.
B. Place the client under airborne precautions.
C. Clean equipment with a sporicidal disinfectant.
D. Use surgical masks when entering the room.
Correct Answer: C
Rationale: C. difficile forms spores that are highly resistant to alcohol-
based hand sanitizers. Therefore, soap and water handwashing must be
used, and environmental surfaces and equipment should be cleaned
with a sporicidal disinfectant (such as bleach-based products) to reduce
transmission. C. difficile requires contact precautions, not airborne
precautions. Surgical masks are not sufficient; gowns and gloves are
required for contact precautions.
Question 3
When providing care for a client who has Clostridium difficile, which of
the following hand hygiene methods is required?
A. Alcohol-based hand rub.
,3|Page
B. Soap and water.
C. Hand sanitizer with 70% ethanol.
D. Warm water only.
Correct Answer: B
Rationale: Soap and water is required for C. difficile because alcohol-
based products, including hand sanitizers with ethanol, are ineffective
against the spores. The mechanical friction of washing with soap and
water is necessary to physically remove the spores from the hands.
Question 4
Which personal protective equipment (PPE) is essential when entering
the room of a client on Airborne Precautions for tuberculosis?
A. Surgical mask.
B. Face shield.
C. N95 respirator.
D. Gown and gloves only.
Correct Answer: C
Rationale: Airborne precautions require an N95 respirator (or higher-
level respirator) to filter out small droplet nuclei (≤5 microns) that
remain suspended in the air for extended periods. A surgical mask
provides only droplet protection and is insufficient for airborne
transmission. Gown and gloves may be required if contact with body
fluids is anticipated, but they do not provide respiratory protection.
, 4|Page
Question 5
In which order should a nurse remove personal protective equipment
(PPE) after completing a task?
A. Gloves, goggles, gown, mask.
B. Mask, goggles, gown, gloves.
C. Goggles, gown, mask, gloves.
D. Gown, mask, goggles, gloves.
Correct Answer: A
Rationale: The standard sequence for doffing (removing) PPE is gloves
first, followed by eyewear/goggles, then the gown, and finally the
mask/respirator. Gloves are considered the most contaminated PPE
item and should be removed first to reduce the risk of contaminating
other equipment and clothing. The mask or respirator is removed last,
typically after leaving the client's room or at the doorway.
Question 6
A nurse is preparing to suction a client with a tracheostomy. Which
action demonstrates correct infection control practice?
A. Reuse the suction catheter after rinsing it with sterile water.
B. Maintain sterile technique throughout the suctioning procedure.
C. Wear clean gloves instead of sterile gloves.
D. Disconnect the ventilator tubing before suctioning.
