NCLEX-RN Safety & Infection Control
2026/2027 Practice Exam
25 Original Questions, Highlighted Answers & Detailed Rationales
Coverage: standard and transmission-based precautions, PPE, sterile technique, sharps, falls,
restraints, fire and electrical safety, medication safety, emergency response, and reporting.
How to use this paper
Choose the best answer before reading the highlighted answer and rationale. Review missed concepts against
your current nursing course resources and facility policies.
Originality and scope notice
Every question and rationale was newly written for educational practice. This is not an actual, recalled, leaked, or official examination
and does not guarantee a score. NCLEX is a registered trademark of the National Council of State Boards of Nursing, Inc. This
independent resource is not affiliated with or endorsed by NCSBN.
Original educational practice material - not an official or recalled examination Page 1
, 1. Which action should the nurse use for every client, regardless of diagnosis?
A. Wear an N95 respirator
B. Apply standard precautions
C. Place the client in negative pressure
D. Use sterile gloves for all contact
Answer: B
Rationale: Standard precautions apply to every client and are selected according to anticipated exposure to blood,
body fluids, nonintact skin, or mucous membranes.
Original educational practice material - not an official or recalled examination Page 2
, 2. A client with suspected pulmonary tuberculosis requires which room and respiratory
protection?
A. Positive-pressure room and surgical mask
B. Private room and no mask
C. Negative-pressure room and fit-tested N95 respirator
D. Contact-isolation room and face shield only
Answer: C
Rationale: Airborne precautions require an airborne infection isolation room with negative pressure and a fit-tested
N95 or higher-level respirator.
Original educational practice material - not an official or recalled examination Page 3
2026/2027 Practice Exam
25 Original Questions, Highlighted Answers & Detailed Rationales
Coverage: standard and transmission-based precautions, PPE, sterile technique, sharps, falls,
restraints, fire and electrical safety, medication safety, emergency response, and reporting.
How to use this paper
Choose the best answer before reading the highlighted answer and rationale. Review missed concepts against
your current nursing course resources and facility policies.
Originality and scope notice
Every question and rationale was newly written for educational practice. This is not an actual, recalled, leaked, or official examination
and does not guarantee a score. NCLEX is a registered trademark of the National Council of State Boards of Nursing, Inc. This
independent resource is not affiliated with or endorsed by NCSBN.
Original educational practice material - not an official or recalled examination Page 1
, 1. Which action should the nurse use for every client, regardless of diagnosis?
A. Wear an N95 respirator
B. Apply standard precautions
C. Place the client in negative pressure
D. Use sterile gloves for all contact
Answer: B
Rationale: Standard precautions apply to every client and are selected according to anticipated exposure to blood,
body fluids, nonintact skin, or mucous membranes.
Original educational practice material - not an official or recalled examination Page 2
, 2. A client with suspected pulmonary tuberculosis requires which room and respiratory
protection?
A. Positive-pressure room and surgical mask
B. Private room and no mask
C. Negative-pressure room and fit-tested N95 respirator
D. Contact-isolation room and face shield only
Answer: C
Rationale: Airborne precautions require an airborne infection isolation room with negative pressure and a fit-tested
N95 or higher-level respirator.
Original educational practice material - not an official or recalled examination Page 3
