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1. Which hypertensive patient is most likely to have adverse blood pressure
effects from excessive sodium consumption?
a. 21-year-old Asian American male
b. 35-year-old menstruating female
c. 55-year-old post menopausal female
d. 70-year-old African American male - Correct Answer: d. 70-year-
old African American male
Rationale:
Two groups of patients typically experience adverse blood pressure effects
from consumption of sodium greater than 2,000 mg daily. Those patients
considered to be most sodium sensitive are elderly patients and African
American patients.
2. A patient with poorly controlled hypertension and history of myocardial
infarction 6-years-ago presents today with mild shortness of breath. He
takes quinapril, ASA, metoprolol, and a statin daily. What symptom in NOT
indicative of a heart failure exacerbation?
a. fatigue
b. headache
c. orthopnea
d. cough - Correct Answer: b. headache
Rationale:
Fatigue is a common symptom in cardiac patients that can represent a
worsening of many cardiac diseases such as coronary artery disease, heart
, failure, and valvular dysfunction. Orthopnea and cough, especially
nocturnal, are classic symptoms of heart failure.
3. A patient with newly diagnosed heart failure has started fosinapril in the
last few days. She has developed a cough. What clinical finding can help
distinguish the etiology of the cough as heart failure?
a. It is dry and non-productive.
b. It is wet and worse with recumbence.
c. It is purulent and tachycardia accompanies it.
d. Shortness of breath always results after coughing. - Correct
Answer: b. It is wet and worse with recumbence.
Rationale:
The cough associated with fosinapril (an ACE inhibitor), is dry, non-
productive and may be described as annoying. Its severity does not change
with position or time of day. A cough associated with heart failure is wet,
worse when lying down, and is usually described by patients as "worse at
night". A cough that is purulent and when tachycardia accompanies it is
often associated with fever and probably reflects an infectious process like
pneumonia.
4. A patient with shortness of breath has suspected heart failure. What
diagnostic test would best help determine this?
a. Echocardiogram
b. B type natriuretic peptide (BNP)
c. EKG
d. Chest x-ray - Correct Answer: b. B type natriuretic peptide (BNP)
Rationale:
, BNP is a hormone involved in regulation of blood pressure and fluid volume.
When the BNP level is 80 pg/mL or greater, the sensitivity and specificity is
98% and 92%, favoring a diagnosis of heart failure. Alternatively, BNP level
less than 80 pg/mL strongly suggest that heart failure is not present (some
U.S. institutions use 100 pg/mL). Other conditions may cause elevated BNP
levels: thoracic and abdominal surgery, renal failure, and subarachnoid
hemorrhage. Consequently, careful assessment of the patient is prudent.
Echocardiograms mechanically evaluate the heart and establish an ejection
fraction. If <35-40%, then CHF can usually be diagnosed. Ejection fractions
do not always correlate with patient symptoms. EKG evaluates the electrical
activity of the heart. Chest x-ray can indicate heart failure, but a BNP is a
more sensitive measure.
5. Which class of medication id frequently used to improve long-term
outcomes in patients with systolic dysfunction?
a. Loop diuretics
b. Calcium channel blockers
c. ACE inhibitors
d. Thiazide diuretics - Correct Answer: c. ACE inhibitors
Rationale:
ACE inhibitors are commonly used in patients with systolic dysfunction
because they reduce morbidity and mortality, i.e. these medications alter
prognosis. They also improve symptoms of fatigue, shortness of breath, and
exercise intolerance. Loop and thiazide diuretics improve symptoms, but do
not alter long-term prognosis with heart failure. Beta blockers should be
used in conjunction with ACE inhibitors and diuretics, but not as solo
agents. Beta blockers can potentially worsen heart failure, so their use in
patients with heart failure should be monitored carefully.
, 6. Ramipril has been initiated at a low dose in a patient with heart failure.
What is most important to monitor in about one week?
a. Heart rate
b. Blood pressure
c. EKG
d. Potassium level - Correct Answer: d. Potassium level
Rationale:
ACE inhibitors work in the kidney in the renin angiotensin aldosterone
system and can impair renal excretion of potassium in patients with normal
kidney function. In patients with impaired renal blood flow and/or function,
the risk of hyperkalemia is increased. Common practice is to monitor
potassium, BUN, and Cr at about one week after initiation of an ACE
inhibitor and with each increase in dosage.
7. Which medication listed below could potentially exacerbate heart failure in
a susceptible individual?
a. Metoprolol
b. Furosemide
c. Metformin
d. Acetaminophen - Correct Answer: a. Metoprolol
Rationale:
Metoprolol is a cardioselective beta blocker that decreases heart rate. A
patient with heart failure wil compensate for heart failure by increasing
heart rate to maintain cardiac output (CO). Metoprolol impairs the patient's
ability to increase heart rate when needed to maintain cardiac output
(CO=stroke volume x heart rate). Consequently, the use of beta blockers in
patients with heart failure should be monitored carefully. Furosemide may
actually improve shortness of breath in a patient with heart failure.