LPN PHARMACOLOGY EVALUATION TEST
QUESTIONS AND ANSWERS SET A+
✔✔40. Pick the correct pharmacological effect(s) of direct-acting cholinergic drugs.
A. respiratory paralysis
B. urinary retention
C. increased heart rate
D. bronchodilation
E. none of these - ✔✔E
✔✔41. Which of the following would be a preferred treatment for overactive bladder?
A. neostigmine
B. tolterodine
C. physostigmine
D. bethanechol
E. donepezil - ✔✔B
✔✔42. Which of the following is correct about the nicotinic-muscle (Nm) receptor
blocking drugs?
A. the mechanism of action is the same as represented by dantrolene
B. all of these drugs depolarize the muscle fiber before blockade occurs
C. calcium ions are released from the storage sites
D. there are two groups in this class: either depolarizing agents or nondepolarizing
agents
E. botulinumtoxinA rapidly attaches to these receptors - ✔✔D
✔✔43. Succinylcholine is associated with which of the following actions?
A. stimulation of the actin and myosin muscle fibrils directly
B. liver damage because the drug is metabolized only by the liver
C. peripheral neuromuscular receptor blockade after stimulating the Nm receptors
D. longer duration of action than vecuronium
E. stimulation of presynaptic ACH release - ✔✔C
, ✔✔44. Centrally acting skeletal muscle relaxants
A. include dantrolene and cisatracurium
B. inhibit or reduce activity within the spinal cord (intraneuronal), interrupting the central
stimulus to muscle contraction
C. can only be given parenterally
D. cause systemic release of histamine, leading to hypotension
E. counteract the effect of botulinumtoxin B - ✔✔B
✔✔45. Skeletal muscle relaxants may alter control of respiration because
A. the diaphragm is a skeletal muscle
B. succinylcholine stimulates the respiratory centers in the brain
C. like dantrolene, all muscle relaxants inhibit the action of norepinephrine at the
neuromuscular junction
D. relaxation of the muscles in the lower extremities pulls blood away from the lungs
E. all skeletal muscle relaxants interfere with calcium ion storage in the muscle - ✔✔A
✔✔46. Select the drug or condition(s) that decrease the effects of neuromuscular
blockers.
A. neomycin
B. corticosteroids
C. general anesthetics like isoflurane
D. alcohol
E. myasthenia gravis and spinal cord lesions - ✔✔B
✔✔47. Which of the following is a way in which skeletal muscles are relaxed?
A. blockage of conduction in the spinal cord
B. inhibiting nerve transmission
C. blockage of the Nm receptors
D. decreasing ACH in the neuromuscular junction
E. all of these - ✔✔E
✔✔48. Select reasons for using muscle relaxants during surgical or diagnostic
procedures.
A. reduce muscle tear
B. decrease body temperature
C. potentiate vasodilators
D. increase muscle tone
E. depress respiration - ✔✔A
✔✔49. Which of the following is NOT a potential adverse effect of peripherally acting
skeletal muscle relaxants?
A. difficulty swallowing (dysphagia)
B. skeletal muscle weakness
C. decreased respiration
QUESTIONS AND ANSWERS SET A+
✔✔40. Pick the correct pharmacological effect(s) of direct-acting cholinergic drugs.
A. respiratory paralysis
B. urinary retention
C. increased heart rate
D. bronchodilation
E. none of these - ✔✔E
✔✔41. Which of the following would be a preferred treatment for overactive bladder?
A. neostigmine
B. tolterodine
C. physostigmine
D. bethanechol
E. donepezil - ✔✔B
✔✔42. Which of the following is correct about the nicotinic-muscle (Nm) receptor
blocking drugs?
A. the mechanism of action is the same as represented by dantrolene
B. all of these drugs depolarize the muscle fiber before blockade occurs
C. calcium ions are released from the storage sites
D. there are two groups in this class: either depolarizing agents or nondepolarizing
agents
E. botulinumtoxinA rapidly attaches to these receptors - ✔✔D
✔✔43. Succinylcholine is associated with which of the following actions?
A. stimulation of the actin and myosin muscle fibrils directly
B. liver damage because the drug is metabolized only by the liver
C. peripheral neuromuscular receptor blockade after stimulating the Nm receptors
D. longer duration of action than vecuronium
E. stimulation of presynaptic ACH release - ✔✔C
, ✔✔44. Centrally acting skeletal muscle relaxants
A. include dantrolene and cisatracurium
B. inhibit or reduce activity within the spinal cord (intraneuronal), interrupting the central
stimulus to muscle contraction
C. can only be given parenterally
D. cause systemic release of histamine, leading to hypotension
E. counteract the effect of botulinumtoxin B - ✔✔B
✔✔45. Skeletal muscle relaxants may alter control of respiration because
A. the diaphragm is a skeletal muscle
B. succinylcholine stimulates the respiratory centers in the brain
C. like dantrolene, all muscle relaxants inhibit the action of norepinephrine at the
neuromuscular junction
D. relaxation of the muscles in the lower extremities pulls blood away from the lungs
E. all skeletal muscle relaxants interfere with calcium ion storage in the muscle - ✔✔A
✔✔46. Select the drug or condition(s) that decrease the effects of neuromuscular
blockers.
A. neomycin
B. corticosteroids
C. general anesthetics like isoflurane
D. alcohol
E. myasthenia gravis and spinal cord lesions - ✔✔B
✔✔47. Which of the following is a way in which skeletal muscles are relaxed?
A. blockage of conduction in the spinal cord
B. inhibiting nerve transmission
C. blockage of the Nm receptors
D. decreasing ACH in the neuromuscular junction
E. all of these - ✔✔E
✔✔48. Select reasons for using muscle relaxants during surgical or diagnostic
procedures.
A. reduce muscle tear
B. decrease body temperature
C. potentiate vasodilators
D. increase muscle tone
E. depress respiration - ✔✔A
✔✔49. Which of the following is NOT a potential adverse effect of peripherally acting
skeletal muscle relaxants?
A. difficulty swallowing (dysphagia)
B. skeletal muscle weakness
C. decreased respiration
