PN HESI Pharmacology Exam NEW VERSIONS UPDATED
2026 |200 Questions with Verified Answers & Rationales |
Practical Nursing HESI Exit Exam Prep 2026-2027 |
INSTANT PDF DOWNLOAD
,COVERAGE BY SECTION
Section Topic Questions
1 Medication Administration & Safety 1–20
Cardiovascular Medications
2 21–50
(Antihypertensives, Anticoagulants, Digoxin)
Respiratory Medications (Bronchodilators,
3 51–65
Corticosteroids)
Endocrine & Diabetes Medications (Insulins,
4 66–85
Oral Hypoglycemics, Thyroid)
5 Neurological & Psychiatric Medications 86–105
6 Pain Management & Opioids 106–125
7 Antibiotics & Anti-infectives 126–145
8 Gastrointestinal & Renal Medications 146–165
Special Populations (Geriatric, Pediatric,
9 166–180
Pregnancy)
Antidotes, High-Alert Medications &
10 181–200
Comprehensive Review
Total Questions: 200 | Format: Multiple Choice | Passing Score: 70% | Governing
Body: HESI / Evolve
Section 1: Medication Administration & Safety (Questions 1–20)
,1. A patient is prescribed a medication that has a high first-pass effect. Which route
of administration would be MOST appropriate to bypass this effect?
a) Oral
b) Intramuscular
c) Topical
d) Sublingual
Sublingual administration bypasses the first-pass effect because the medication is absorbed
directly into the bloodstream through the sublingual mucosa, avoiding the hepatic portal
system. Oral administration is subject to first-pass metabolism .
2. What are the "Five Rights" of medication administration?
a) Right Patient, Drug, Dose, Route, Time
b) Right Patient, Dose, Frequency, Route, Documentation
c) Right Drug, Dose, Route, Time, Refill
d) Right Patient, Drug, Dose, Route, Education
The "Five Rights" are fundamental to medication safety: right patient, drug, dose, route, and
time. Right documentation, indication, and patient education are often considered additional
rights .
3. A nurse is preparing to administer medications. Which action is the highest
priority?
, a) Check the client's room number
b) Verify the client's insurance information
c) Check the client's name band using two identifiers
d) Ask the client their height and weight
Patient safety is paramount. The "Rights of Medication Administration" include using two
client identifiers (name and date of birth) to ensure the right patient receives the medication.
Checking a room number is unsafe as clients may change rooms .
4. How should the nurse safely prepare medications?
a) Have another nurse check the medication
b) Check the medication label three times
c) Prepare multiple patients' medications at once
d) Use the medication even if the label is unreadable
Safe preparation requires checking the medication label at least three times: when taking
the medication from storage, when preparing it, and before returning it to storage. Never
prepare medications for multiple patients at once .
5. A client is receiving a transdermal fentanyl patch (Duragesic) for chronic pain.
Which instruction is most important?
a) "Apply the patch to a hairy area for better adherence."
b) "If the pain gets worse, apply a second patch."
2026 |200 Questions with Verified Answers & Rationales |
Practical Nursing HESI Exit Exam Prep 2026-2027 |
INSTANT PDF DOWNLOAD
,COVERAGE BY SECTION
Section Topic Questions
1 Medication Administration & Safety 1–20
Cardiovascular Medications
2 21–50
(Antihypertensives, Anticoagulants, Digoxin)
Respiratory Medications (Bronchodilators,
3 51–65
Corticosteroids)
Endocrine & Diabetes Medications (Insulins,
4 66–85
Oral Hypoglycemics, Thyroid)
5 Neurological & Psychiatric Medications 86–105
6 Pain Management & Opioids 106–125
7 Antibiotics & Anti-infectives 126–145
8 Gastrointestinal & Renal Medications 146–165
Special Populations (Geriatric, Pediatric,
9 166–180
Pregnancy)
Antidotes, High-Alert Medications &
10 181–200
Comprehensive Review
Total Questions: 200 | Format: Multiple Choice | Passing Score: 70% | Governing
Body: HESI / Evolve
Section 1: Medication Administration & Safety (Questions 1–20)
,1. A patient is prescribed a medication that has a high first-pass effect. Which route
of administration would be MOST appropriate to bypass this effect?
a) Oral
b) Intramuscular
c) Topical
d) Sublingual
Sublingual administration bypasses the first-pass effect because the medication is absorbed
directly into the bloodstream through the sublingual mucosa, avoiding the hepatic portal
system. Oral administration is subject to first-pass metabolism .
2. What are the "Five Rights" of medication administration?
a) Right Patient, Drug, Dose, Route, Time
b) Right Patient, Dose, Frequency, Route, Documentation
c) Right Drug, Dose, Route, Time, Refill
d) Right Patient, Drug, Dose, Route, Education
The "Five Rights" are fundamental to medication safety: right patient, drug, dose, route, and
time. Right documentation, indication, and patient education are often considered additional
rights .
3. A nurse is preparing to administer medications. Which action is the highest
priority?
, a) Check the client's room number
b) Verify the client's insurance information
c) Check the client's name band using two identifiers
d) Ask the client their height and weight
Patient safety is paramount. The "Rights of Medication Administration" include using two
client identifiers (name and date of birth) to ensure the right patient receives the medication.
Checking a room number is unsafe as clients may change rooms .
4. How should the nurse safely prepare medications?
a) Have another nurse check the medication
b) Check the medication label three times
c) Prepare multiple patients' medications at once
d) Use the medication even if the label is unreadable
Safe preparation requires checking the medication label at least three times: when taking
the medication from storage, when preparing it, and before returning it to storage. Never
prepare medications for multiple patients at once .
5. A client is receiving a transdermal fentanyl patch (Duragesic) for chronic pain.
Which instruction is most important?
a) "Apply the patch to a hairy area for better adherence."
b) "If the pain gets worse, apply a second patch."
