ONS Chemotherapy Immunotherapy
Certificate Questions and Answers
1. Define neoadjuvant therapy: Treatment is given prior to surgery to shrink the tumor
2. Define adjuvant therapy: Additional cancer treatment given after the primary treatment
to lower the risk that the cancer reoccur
3. 3 subcategories of alkylating agents:: 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work
similarly)
3. Nitrosoureas
4. Common alkylating agents:: Cyclophosphamide
(Cytoxan) Ifosfamide (Ifex)
Bendamustine (Treanda)
5. Common platinum-based agents:: Cisplatin
(Platinol) Carboplatin (Paraplatin)
6. What is unique about nitrosoureas agents?: Able to cross the blood-brain
barrier; can be effective in treating some brain tumors
,7. Common nitrosoureas agents:: Carmustine
(BiCNU) Lomustine (CeeNu)
Streptozocin (Zanosar)
8. Hypersensitivity can occur with late doses of:: Carboplatin
9. These agents are typically categorized as highly emetogenic:: 1.
Alkylating agents
2. Nitrosoureas
10. Pre-administration labs for alkylating agents and
nitrosoureas:: BUN Creatinine
CBC w/ ditt
11. What is the medication Mesna used for?: Bladder protectant with
administration of cy-clophosphamide or ifosfamide
12. Instruct pts receiving to avoid
exposure to cold air and consuming cold fluids for 3-4 days
following treatment: Oxaliplatin
13. How do antimetabolites function?: By blocking DNA and RNA growth by
interfering with enzymes needed for normal cell metabolism
, 14. Antimetabolites work in the
phase.: S
15. Common side effects of antimetabolites::
Myelosuppression GI toxicities
Photosensitivity
Hand-foot
syndrome
16. Common antimetabolite drugs::
Azacitidine Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
17. The institute for Safe Medication Practices recommends
what route of administration for vincristine?: IV piggyback via gravity
18. Anthracycline antitumor abx work by:: Interfering with enzymes necessary for
DNA to replicate in ALL phases of the cell cycle
19. The two major classifications of antitumor antibiotics are::
Anthracyclines Non-anthracyclines
Certificate Questions and Answers
1. Define neoadjuvant therapy: Treatment is given prior to surgery to shrink the tumor
2. Define adjuvant therapy: Additional cancer treatment given after the primary treatment
to lower the risk that the cancer reoccur
3. 3 subcategories of alkylating agents:: 1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work
similarly)
3. Nitrosoureas
4. Common alkylating agents:: Cyclophosphamide
(Cytoxan) Ifosfamide (Ifex)
Bendamustine (Treanda)
5. Common platinum-based agents:: Cisplatin
(Platinol) Carboplatin (Paraplatin)
6. What is unique about nitrosoureas agents?: Able to cross the blood-brain
barrier; can be effective in treating some brain tumors
,7. Common nitrosoureas agents:: Carmustine
(BiCNU) Lomustine (CeeNu)
Streptozocin (Zanosar)
8. Hypersensitivity can occur with late doses of:: Carboplatin
9. These agents are typically categorized as highly emetogenic:: 1.
Alkylating agents
2. Nitrosoureas
10. Pre-administration labs for alkylating agents and
nitrosoureas:: BUN Creatinine
CBC w/ ditt
11. What is the medication Mesna used for?: Bladder protectant with
administration of cy-clophosphamide or ifosfamide
12. Instruct pts receiving to avoid
exposure to cold air and consuming cold fluids for 3-4 days
following treatment: Oxaliplatin
13. How do antimetabolites function?: By blocking DNA and RNA growth by
interfering with enzymes needed for normal cell metabolism
, 14. Antimetabolites work in the
phase.: S
15. Common side effects of antimetabolites::
Myelosuppression GI toxicities
Photosensitivity
Hand-foot
syndrome
16. Common antimetabolite drugs::
Azacitidine Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
17. The institute for Safe Medication Practices recommends
what route of administration for vincristine?: IV piggyback via gravity
18. Anthracycline antitumor abx work by:: Interfering with enzymes necessary for
DNA to replicate in ALL phases of the cell cycle
19. The two major classifications of antitumor antibiotics are::
Anthracyclines Non-anthracyclines
