NGR 6172 QUIZ 2 CHAPTERS 7 8 9 AND 10 UPDATED ACTUAL QUESTIONS AND CORRECT ANSWERS

NGR 6172 QUIZ 2 CHAPTERS 7 8 9 AND 10 UPDATED
ACTUAL QUESTIONS AND CORRECT ANSWERS

Question:
What Rx do CYP2D6 Variants affect? What do they do? Should they get genetic Testing?
Answer:
Can't activate Tamoxifen, causing“ Therapeutic Fx against BC Genetic testing is not
FDA-recommended, but should get it anyways

Question:
What Rx do CYP2C19 Variants affect? Should they get genetic Testing?
Answer:
Can't activate Clopidogrel, causing “ Therapeutic Fx Genetic testing recommended

Question:
What Rx do CYP2C9 Variants affect? What do they do? Should they get genetic Testing?
Answer:
Affects Warfarin Causes ‘ Toxicity (buildup) Genetic testing recommended

Question:
What Rx do TMPT variants affect? What do they do? Should they get genetic Testing?
Answer:
Affects Thiopurines (Thioguanine, Mercaptopurine) Causes ‘ marrow toxicity Genetic
testing recommended

Question:
What Rx do ADRB1 Variants affect? What do they do? Should they get genetic Testing?
Answer:
Affects Beta-Blockers Causes ‘ Therapeutic Fx of BBs No recommendation for genetic
testing.

Question:
What Rx do VKORC1 Variants affect? What do they do? Should they get genetic Testing?
Answer:
‘ Rx sensitivity to Warfarin, causing anticoag with “ warfarin dose. Genetic testing
recommended

Question:
What Rx does HER2 Overexpression affect? What do they do? Should they get genetic
Testing?
Answer:
‘ Therapeutic fx of Trastuzumab Trastuzumab ONLY fights BC that overexpresses HER2
Genetic testing REQUIRED

,Question:
What Rx does EGFR Overexpression affect? What do they do? Should they get genetic
Testing?
Answer:
‘ Therapeutic fx of Cetuximab Cetuximab ONLY fights colorectal cancers that express
EGFR ***Every Giant colon's Favorite Remedy*** Genetic testing REQUIRED

Question:
What Rx does CCR5 Tropism affect? What do they do? Should they get genetic Testing?
Answer:
‘ Therapeutic fx of Maraviroc Maraviroc ONLY fights HIV strains that express CCR5
Genetic testing REQUIRED

Question:
What Rx does HLA-B*1502 affect? What do they do? Should they get genetic Testing?
Answer:
Affects Carbamazepine Causes ‘ Toxicity = Risk for deadly skin rxn. Genetic testing for
Asian patients

Question:
What Rx does HLA-B*5701 affect? What do they do? Should they get genetic Testing?
Answer:
Affects Abacavir Causes ‘ Toxicity = Risk of fatal hypersensitivity rxns **HLA-B*5701
Abacavir is no fun** Genetic testing recommended

Question:
DELETE
Answer:
DELETE

Question:
Antiseizure Rx that should be avoided during pregnancy due to teratogenicity?
Answer:
Carbamazepine Phenytoin Topiramate Valproic Acid "Can't Play Tag with Val while
Pregnant"

Question:
Sex Hormones that should be avoided during pregnancy due to teratogenicity?
Answer:
Androgens (Danazol) Diethylstilbestrol Estrogens

Question:
Antimicrobials that should be avoided during pregnancy due to teratogenicity?
Answer:
Tetracycline Trimethoprim-Sulfamethoxazole

, Question:
Rx that should be avoided during pregnancy due to teratogenicity (Other than
Antimicrobials, Sex hormones, Antiseizures, and Anticancer/Immunosuppressants)
Answer:
ETOH + Nicotine + NSAIDs + Lithium Statins + ACE-inhibitors + Warfarin 5-a-reductase
inhibitors (dutasteride, finasteride) Anti-thyroids (PTU, methimazole) Retinoids
(Isotretinoin, etretinate, large doses of Vit A) Oral hypoglycemics (tolbutamine)

Question:
Explain Pregnancy Risk Factor Category A
Answer:
Remote risk; tested in humans

Question:
Explain Pregnancy Risk Factor Category B
Answer:
Slightly more risk; no human data

Question:
Explain Pregnancy Risk Factor Category C
Answer:
Greater risk; no adequate human studies

Question:
Explain Pregnancy Risk Factor Category D
Answer:
Proven risk; benefits may outweigh risks

Question:
Explain Pregnancy Risk Factor Category X
Answer:
Proven risk; contraindicated

Question:
What Rx can have altered metabolism in Patients of European Descent due to Genetic
Variants?
Answer:
Must adjust Isoniazid dose (for TB) since half of people metabolize it slow + other half
metabolizes it fast Some have variant CYP2D6 that can't convert codeine into morphine.
"Europeans ISO codeine"

Question:
Sample Types for Genetic + Pharmacogenomic Testing
Answer:
Blood, saliva, urine, amniotic fluid, tissue, hair