Neuroscience 18 - CNS & Drugs (Dr. Thompson)
Study online at https://quizlet.com/_gsaqlk
1. What are a few symptoms of depression? • Feelings of worthless-
ness, hopelessness, guilt
• Significant change in
weight or appetite
• Fatigue, loss of energy
• Agitation, restlessness,
irritability
• Difficulty concentrating
and making decisions
• Thoughts of death or
suicide
2. What is the amine hypothesis of mood? Depression arises from a
functional decrease in the
activity of neurotransmit-
ters in neural pathways
that function in the ex-
pression of mood states
3. What is the neurotransmitter receptor hypothesis? Long-term antidepres-
sants act to alter the num-
ber and/or sensitivity of
both pre and post synap-
tic receptors to restore the
normal balance between
, Neuroscience 18 - CNS & Drugs (Dr. Thompson)
Study online at https://quizlet.com/_gsaqlk
receptors and transmit-
ter. This change correlates
better timewise with clini-
cal improvement
4. 4 examples of antidepressants TCAs, MAOIs, SSRIs, SNRIs
5. T/F: Antidepressant are only used to treat depressed False (These drugs can
individuals also be used for anxiety,
OCD, EDs, PTSD, sleep dis-
orders, and more)
6. What can be prescribed to treat endogenous depres- TCAs
sion?
7. What can be prescribed to treat the following: TCAs
- Bed-wetting
- Bulimia
- Panic disorders
, Neuroscience 18 - CNS & Drugs (Dr. Thompson)
Study online at https://quizlet.com/_gsaqlk
- Phobias
- Chronic pain
- Neuralgias
8. What is the first choice of drugs for depression? What 1st: SSRIs
is second choice? 2nd: TCAs
9. T/F: TCAs can be prescribed on an "as needed" basis False (improvement takes
several weeks of chronic
drug administration)
10. Dental uses for this drug include treatment of chronic TCAs
orofacial pain, Bruxism:
11. in terms of acetylcholine, TCAs have _________ effects anticholinergic (ex: dry
mouth, urinary retention,
orthostatic hypotension)
12. what is the main problem with TCAs?
, Neuroscience 18 - CNS & Drugs (Dr. Thompson)
Study online at https://quizlet.com/_gsaqlk
non-specific neurotrans-
mitter blocker
13. this type of antidepressant has many side effects in- TCAs
cluding:
- anticholinergic effects (dry mouth/ urinary reten-
tion)
- antihistamine effects (sedation)
- cardiotoxic (due to NE reuptake block in ANS, will
potentiate adrenergic effects)
14. for dentists, patients taking TCA's should be identified epinephrine
because of the drug's interaction in has with ________
15. T/F: In patient's taking TCA's, avoid the use of epineph- TRUE
rine in local anesthetic preparations. Epi containing
retraction cords are also contraindicated
16. what enzyme breaks down norepinephrine in the monoamine oxidase
synaptic terminals once it experiences re-uptake?
17. "Wine and cheese syndrome" hypertensive crisis from MAOIs (Monoamine Oxi-
tyramine in food not being metabolized. This is a pos- dase Inhibitors)
sible drug interaction with __________
Study online at https://quizlet.com/_gsaqlk
1. What are a few symptoms of depression? • Feelings of worthless-
ness, hopelessness, guilt
• Significant change in
weight or appetite
• Fatigue, loss of energy
• Agitation, restlessness,
irritability
• Difficulty concentrating
and making decisions
• Thoughts of death or
suicide
2. What is the amine hypothesis of mood? Depression arises from a
functional decrease in the
activity of neurotransmit-
ters in neural pathways
that function in the ex-
pression of mood states
3. What is the neurotransmitter receptor hypothesis? Long-term antidepres-
sants act to alter the num-
ber and/or sensitivity of
both pre and post synap-
tic receptors to restore the
normal balance between
, Neuroscience 18 - CNS & Drugs (Dr. Thompson)
Study online at https://quizlet.com/_gsaqlk
receptors and transmit-
ter. This change correlates
better timewise with clini-
cal improvement
4. 4 examples of antidepressants TCAs, MAOIs, SSRIs, SNRIs
5. T/F: Antidepressant are only used to treat depressed False (These drugs can
individuals also be used for anxiety,
OCD, EDs, PTSD, sleep dis-
orders, and more)
6. What can be prescribed to treat endogenous depres- TCAs
sion?
7. What can be prescribed to treat the following: TCAs
- Bed-wetting
- Bulimia
- Panic disorders
, Neuroscience 18 - CNS & Drugs (Dr. Thompson)
Study online at https://quizlet.com/_gsaqlk
- Phobias
- Chronic pain
- Neuralgias
8. What is the first choice of drugs for depression? What 1st: SSRIs
is second choice? 2nd: TCAs
9. T/F: TCAs can be prescribed on an "as needed" basis False (improvement takes
several weeks of chronic
drug administration)
10. Dental uses for this drug include treatment of chronic TCAs
orofacial pain, Bruxism:
11. in terms of acetylcholine, TCAs have _________ effects anticholinergic (ex: dry
mouth, urinary retention,
orthostatic hypotension)
12. what is the main problem with TCAs?
, Neuroscience 18 - CNS & Drugs (Dr. Thompson)
Study online at https://quizlet.com/_gsaqlk
non-specific neurotrans-
mitter blocker
13. this type of antidepressant has many side effects in- TCAs
cluding:
- anticholinergic effects (dry mouth/ urinary reten-
tion)
- antihistamine effects (sedation)
- cardiotoxic (due to NE reuptake block in ANS, will
potentiate adrenergic effects)
14. for dentists, patients taking TCA's should be identified epinephrine
because of the drug's interaction in has with ________
15. T/F: In patient's taking TCA's, avoid the use of epineph- TRUE
rine in local anesthetic preparations. Epi containing
retraction cords are also contraindicated
16. what enzyme breaks down norepinephrine in the monoamine oxidase
synaptic terminals once it experiences re-uptake?
17. "Wine and cheese syndrome" hypertensive crisis from MAOIs (Monoamine Oxi-
tyramine in food not being metabolized. This is a pos- dase Inhibitors)
sible drug interaction with __________
