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NR567 Final Exam Mastery: 200 Advanced
Pharmacology Questions with Rationales
Covering Anticoagulation, Psychiatry, Critical
Care, and Antimicrobial Therapy for AGACNP
Success
NR567 Final Exam Study Guide: 200 Practice
Questions with Rationales
Section 1: Psychopharmacology & Neurologic
Agents (Questions 1-25)
Question 1
A patient taking risperidone (Risperdal)
develops hyperprolactinemia. Which
medication may help manage this side effect?
A) Haloperidol (Haldol)
B) Bromocriptine (Parlodel)
,2
C) Promethazine (Phenergan)
D) Chlorpromazine (Thorazine)
☑VERIFIED ANSWER: B) Bromocriptine
(Parlodel)
Rationale: Hyperprolactinemia is a common
side effect of first- and second-generation
antipsychotics due to dopamine D2 receptor
blockade in the tuberoinfundibular pathway.
Bromocriptine is a dopamine receptor agonist
that reduces prolactin secretion. Haloperidol
and chlorpromazine are antipsychotics that
would worsen hyperprolactinemia, while
promethazine is an antihistamine with no effect
on prolactin levels.
Question 2
,3
A 35-year-old female with long-standing
anxiety treated with diazepam (Valium) triples
her daily dose during the COVID-19 pandemic.
She is found extremely lethargic and obtunded
two days later. Which pharmaceutical agent
should the NP order?
A) Naloxone (Narcan)
B) Flumazenil (Romazicon)
C) Activated charcoal
D) Thiamine (Vitamin B1)
☑VERIFIED ANSWER: B) Flumazenil
(Romazicon)
Rationale: Flumazenil is a competitive
benzodiazepine receptor antagonist that
reverses the sedative effects of benzodiazepine
overdose. This patient's symptoms of lethargy
and obtundation following a massive increase
in diazepam dose indicate benzodiazepine
, 4
toxicity. Naloxone is used for opioid overdose,
thiamine for Wernicke-Korsakoff syndrome, and
activated charcoal is not the immediate
treatment for a comatose patient.
Question 3
What medication is used to treat akathisia
induced by antipsychotic medications?
A) Propranolol
B) Diphenhydramine
C) Benztropine
D) Lorazepam
☑VERIFIED ANSWER: A) Propranolol
Rationale: Akathisia is an extrapyramidal
symptom characterized by subjective
restlessness and an inability to remain still.
Beta-blockers, particularly propranolol, are first-
NR567 Final Exam Mastery: 200 Advanced
Pharmacology Questions with Rationales
Covering Anticoagulation, Psychiatry, Critical
Care, and Antimicrobial Therapy for AGACNP
Success
NR567 Final Exam Study Guide: 200 Practice
Questions with Rationales
Section 1: Psychopharmacology & Neurologic
Agents (Questions 1-25)
Question 1
A patient taking risperidone (Risperdal)
develops hyperprolactinemia. Which
medication may help manage this side effect?
A) Haloperidol (Haldol)
B) Bromocriptine (Parlodel)
,2
C) Promethazine (Phenergan)
D) Chlorpromazine (Thorazine)
☑VERIFIED ANSWER: B) Bromocriptine
(Parlodel)
Rationale: Hyperprolactinemia is a common
side effect of first- and second-generation
antipsychotics due to dopamine D2 receptor
blockade in the tuberoinfundibular pathway.
Bromocriptine is a dopamine receptor agonist
that reduces prolactin secretion. Haloperidol
and chlorpromazine are antipsychotics that
would worsen hyperprolactinemia, while
promethazine is an antihistamine with no effect
on prolactin levels.
Question 2
,3
A 35-year-old female with long-standing
anxiety treated with diazepam (Valium) triples
her daily dose during the COVID-19 pandemic.
She is found extremely lethargic and obtunded
two days later. Which pharmaceutical agent
should the NP order?
A) Naloxone (Narcan)
B) Flumazenil (Romazicon)
C) Activated charcoal
D) Thiamine (Vitamin B1)
☑VERIFIED ANSWER: B) Flumazenil
(Romazicon)
Rationale: Flumazenil is a competitive
benzodiazepine receptor antagonist that
reverses the sedative effects of benzodiazepine
overdose. This patient's symptoms of lethargy
and obtundation following a massive increase
in diazepam dose indicate benzodiazepine
, 4
toxicity. Naloxone is used for opioid overdose,
thiamine for Wernicke-Korsakoff syndrome, and
activated charcoal is not the immediate
treatment for a comatose patient.
Question 3
What medication is used to treat akathisia
induced by antipsychotic medications?
A) Propranolol
B) Diphenhydramine
C) Benztropine
D) Lorazepam
☑VERIFIED ANSWER: A) Propranolol
Rationale: Akathisia is an extrapyramidal
symptom characterized by subjective
restlessness and an inability to remain still.
Beta-blockers, particularly propranolol, are first-
