Endocrine Pathophysiology |
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, Endocrine Pathophysiology
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1. Pituitary Dis- Uncommon. Usually present as either a hyperfunction or a hypofunction of the
eases pituitary or a localized mass lesion causing compression of the optic chiasm or
basal portion of the brain
2. Hormones se- TSH, ACTH, FSH and LH, GH, Prolactin, endorphins
creted from ante-
rior pituitary
3. hormones se- Oxytocin and ADH
creted from pos-
terior pituitary
4. What is the worst Anaplastic. rare tumor with an extremely poor prognosis with most patients dying
of the 4 thy- within one year of diagnosis
roid carcinomas
(Papillary, Follic-
ular, Medullary
and Anaplastic)?
5. Pituitary Hyper- Can present in several forms depending on which one of the five cells is hyper-
function functioning. Pituitary is enlarged due to these functioning adenomas, which are
composed of a single cell type or several cell types.
6. Oxytocin is related to the release of milk when the baby suckles. Also causes contraction of
smooth muscle of uterus
7. Prolactin starts production of the milk
8. Number one Prolactinoma: small, benign tumor, composed of prolactin-secreting cells
most common
adenoma (pitu-
itary hyperfunc-
tion)
, Endocrine Pathophysiology
Endocrine Pathophysiology.pdf
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9. What is a pro- Tumors composed of lactropic cells
lactinoma?
10. Signs and symp- hyperprolactinemia leads to amenorrhea, Galactorrhea (spontaneous milk secre-
toms of pro- tion unrelated to pregnancy) and infertility.
lactinoma in
Women
11. Signs and symp- vague and may include impotence or loss of libido
toms of pro-
lactinoma in Men
12. How do pro- hyperprolactinemia inhibits the pulsatile secretion of LH, which is essential for
lactinomas oc- normal ovulation to occur
cur?
13. Treatment for Inhibit function of prolactinomas with Bromocriptine, an inhibitor of prolactin
prolactinomas secretion. Transnasal surgery to the Sella Tursica is reserved for larger tumors.
14. What are the oth- Somatotropic and Corticotropic Adenomas
er less common
adenomas (pitu-
itary hyperfunc-
tion)?