HOSA Pathophysiology Notes
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1. pathology the scientific study of disease
2. asymptomatic without symptoms
3. syndrome A group of symptoms typical of a particular disease or condition
4. symptoms subjective findings
5. signs objective findings
6. predisposing fac- risk factors; make a person vulnerable to a disease
tors
7. chronic A condition that develops slowly and lasts a long period of time
8. acute A condition with a rapid onset with a short course (less than 6 months) ending
in recovery or death
9. pathogenesis the stages of development of a disease
10. C-reactive protein protein produced by the liver, levels of CRP increase when inflammation is
present in the body; a blood test can be done to detect inflammation in the
body
11. Widespread inflam- marked by systemic symptoms, such as fever, malaise, and loss of appetite,
mation elevated white blood cells
12. ESR Erythrocyte Sedimentation Rate; measures the rate that red blood cells fall to
the bottom of a tube in mm/hr. Rate is higher w/ autoimmune disorders.
Measures amount of inflammation in the body, can be used to help with
diagnoses.
13. Acute inflammation a normal, protective physiologic response to tissue injury and disease; is
accompanied by redness, swelling, pain, and loss of function
, HOSA Pathophysiology Notes
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14. ischemia holding back/obstructing the flow of blood
15. exudative response/ attempts to wall off, or destroy, and digest bacteria and dead/foreign mater-
inflammation exu- ial; this in tissues causes swelling and the excess fluid puts pressure on tissue
date and nerve endings, causing pain.
16. phagocytic the process in which cells surround and digest certain particles
17. Methicillin-resistant "superbug" that is to blame for aggressive skin & soft tissue infections, quickly
strains of developing into abscesses and cellulitis; sometimes called "flesh-eating bac-
Staphylococcus teria".
aureus (MRSA)
18. autosomes the 22 remaining pairs of chromosomes
19. genotype an organism's genetic makeup
20. karyotype a display of the chromosome pairs of a cell arranged by size and shape
21. phenotype an organism's physical appearance, or visible traits.
22. autosomal domi- the gene in question is located on an autosome & the mutant phenotype
nant is seen even if a normal gene is present (eg- Huntington's and Marfan's
syndrome)
23. autosomal recessive gene located on an autosome but is insufficient to produce mutant phenotype
unless both genes are inherited (eg- cystic fibrosis & phenylketonuria).
24. X-linked (sex linked) recessive; the gene is located only on the X chromosome: more common in
males. (eg- Duchenne's muscular dystrophy and hemophilia A).
25. neoplasm A new growth of different or abnormal tissue, such as a tumor or wart; can
be benign or malignant
26. cancer a group of diseases characterized by uncontrolled cell proliferation