BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION KATZUNG TREVOR TEST BANK INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS

BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION
KATZUNG TREVOR TEST BANK
INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS

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Basic and Clinical Pharmacology 15th Edition Katzung Trevor Test Bank
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Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
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1.
A nurse working in radiology administers iodine to a patient who is havi
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ng a computed tomography (CT) scan. The nurse working on the oncology
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unit administers chemotherapy to patients who have cancer. At the Public
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Health Department, a nurse administers a measles-mumps-
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rubella (MMR) vaccine to a 14-month-
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old child as a routine immunization. Which branch of pharmacology best d
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escribes the actions of all three nurses?
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A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:

Pharmacology is the study of the biologic effects of chemicals. Nurses are
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involved with clinical pharmacology or pharmacotherapeutics, which is a b
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ranch of pharmacology that deals with the uses of drugs to treat, prevent, a
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nd diagnose disease. The radiology nurse is administering a drug to help di
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agnose a disease. The oncology nurse is administering a drug to help treat a
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disease. Pharmacoeconomics includes any costs involved in drug therapy.
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Pharmacodynamics involves how a drug affects the body and pharmacokineti xz xz xz xz xz xz xz xz xz


cs is how the body acts on the body.
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2.
When involved in phase III drug evaluation studies, w
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hat responsibilities would the nurse have?
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A) Working with animals who are given experimental drugs
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B) Choosing appropriate patients to be involved in the drug study
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C) Monitoring and observing patients closely for adverse effects
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D) Conducting research to determine effectiveness of the drug
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Ans: C
Feedback:

Phase III studies involve use of a drug in a vast clinical population in whic
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h patients are asked to record any symptoms they experience while taking t
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he drugs. Nurses may be responsible for helping collect and analyze the in
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formation to be shared with the Food and Drug Administration (FDA) but
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would not conduct research independently because nurses do not prescribe
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medications. Use of animals in drug testing is done in the preclinical trials.
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Select patients who are involved in phase II studies to participate in studie
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s where the participants have the disease the drug is intended to treat. Thes
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e patients are monitored closely for drug action and adverse effects. Phase
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I studies involve healthy human volunteers who are usually paid for their
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participation. Nurses may observe for adverse effects and toxicity.
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3.
A physician has ordered intramuscular (IM) injections of morphine, a na
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rcotic, every 4 hours as needed for pain in a motor vehicle accident victim.
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The nurse is aware this drug has a high abuse potential. Under what catego
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ry would morphine be classified?
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A) Schedule I xz




B) Schedule II xz




C) Schedule III xz




D) Schedule IV xz




Ans: B
Feedback:

Narcotics with a high abuse potential are classified as Schedule II drugs
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because of severe dependence liability. Schedule I drugs have high abuse
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potential and no accepted medical use. Schedule III drugs have a lesser a
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buse potential than II and an accepted medical use. Schedule IV drugs have
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low abuse potential and limited dependence liability.
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4.
What concept is considered when generic drugs are substituted for bra
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nd name drugs?
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A) Bioavailability

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B) Critical concentration xz




C) Distribution
D) Half-life
Ans: A
Feedback:

Bioavailability is the portion of a dose of a drug that reaches the systemicxz xz xz xz xz xz xz xz xz xz xz xz xz


circulation and is available to act on body cells. Binders used in a generi
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c drug may not be the same as those used in the brand name drug. Theref
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ore, the way the body breaks down and uses the drug may differ, which
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may eliminate a generic drug substitution. Critical concentration is the amo
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unt of a drug that is needed to cause a therapeutic effect and should not d
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iffer between generic and brand name medications. Distribution is the pha
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se of pharmacokinetics, which involves the movement of a drug to the bo
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dys tissues and is the same in generic and brand name drugs. A drugs half-
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life is the time it takes for the amount of drug to decrease to half the pea
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k level, which should not change when substituting a generic medication.
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5.
A nurse is assessing the patients home medication use. After listening to
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the patient list current medications, the nurse asks what priority question
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?
A) Do you take any generic medications?
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B) Are any of these medications orphan drugs?
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C) Are these medications safe to take during pregnancy?
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D) Do you take any over-the-counter medications?
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Ans: D
Feedback:

It is important for the nurse to specifically question use of over-the-
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counter medications because patients may not consider them important. Th
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e patient is unlikely to know the meaning of orphan drugs unless they too
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are health care providers. Safety during pregnancy, use of a generic medic
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ation, or classification of orphan drugs are things the patient would be una
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ble to answer but could be found in reference books if the nurse wishes to r
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esearch them. xz