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1. MAOIs (monoamine oxidase inhibitors) affect which neurotransmitters?
A. Serotonin, Dopamine, Norepinephrine
B. Serotonin, GABA, Glutamate
C. Acetylcholine, Dopamine, Norepinephrine
D. Dopamine, GABA, Acetylcholine ANS: A. Serotonin, Dopamine, Norepinephrine
2. Which of the following is considered first line treatment for depression?
A. SSRI
B. FGA
C. SNRI
D. MAOI ANS: A. SSRI
3. When treating a patient for major depression disorder which medication would the
PMHNP consider first?
A. Depakote
B. Selegiline
C. Escitalopram
D. Isocarboxazid ANS: C. Escitalopram
4. Which of the following medication should be considered for a patient diagnosed with
major depressive disorder who reports "always forgetting to take my pills"?
, NR 546 Final PRACTICE EXAM Psychopharmacology
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A. Mirtazapine
B. Fluvoxamine
C. Fluoxetine
D. Carbemazepine ANS: C. Fluoxetine
5. Which of the following medication has a black box warning of a life-threatening skin
rash?
A. Lithium
B. Lamotrigine
C. Lurasidone
D. Lorazepam ANS: B. Lamotrigine
6. Which medication is considered the best tolerated SSRI?
A. Venlafaxine
B. Bupropion
C. Setraline
D. Escitalopram ANS: D. Escitalopram
7. During a 4 week follow up appointment, Rashida, who is prescribed Sertraline 25mg
qAM reports slight improvement in depression symptoms and tolerating medication
well. Which of the following should the PMHNP do?
A. Increase Setraline dose
B. Switch to an SNRI
C. Switch to a different SSRI
D. Add Trazodone qHS for sleep. ANS: A. Increase Setraline dose
8. Which medication should be avoided for the 66 year patient diagnosed with major
depressive disorder and anxiety with a reported fall 3 months ago?
, NR 546 Final PRACTICE EXAM Psychopharmacology
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A. Citalopram
B. Setraline
C. Paroxetine
D. Aripiprazole ANS: C. Paroxetine
9. A patient reports upset stomach and diarrhea 3 days after taking new prescription of
sertraline. Which of the following is the most appropriate response from the PMHNP?
A. "Start doubling the dose of sertraline and your symptoms will begin to ease up".
B. "Most side effects subside after 4-5 days. Your body is getting adjusted to the
increased serotonin levels".
C. "Stop taking it immediately and go to the local emergency department".
D. "You must take Sertraline with food, otherwise you will continue to expe-
rience GI symptoms". ANS: B. "Most side effects subside after 4-5 days. Your body is
getting adjusted to the increased serotonin levels".
10. During a 2 week follow up appointment, the patient reports no improvement in
depressive symptoms with escitalopram. Which of the following statement made by the
PMHNP is correct?
A. "Let's discontinue escitalopram and start you on something stronger".
B. "It can take up to 6 weeks before you notice improvements of depressive symptoms".
C. "I am going to prescibe Trazodone. Take it at night to help you sleep".
D. "Start taking two pills at a time". ANS: B. "It can take up to 6 weeks before you notice
improvements of depressive symptoms".
11. Duloxetine effects which two neurotransmitters?
A. serotonin and norepinephrine
B. serotonin and dopamine
C. norepinephrine and GABA