, Contents
Section 1
General Pharmacological Principles
1. Introduction, Routes of Drug Administration .........................................................................................3
2. Pharmacokinetics: Membrane Transport, Absorption and Distribution of Drugs ................. 11
3. Pharmacokinetics: Metabolism and Excretion of Drugs, Kinetics of Elimination .................... 23
4. Pharmacodynamics: Mechanism of Drug Action; Receptor Pharmacology .............................. 37
5. Aspects of Pharmacotherapy; Clinical Pharmacology and Drug Development ....................... 59
6. Adverse Drug Effects ................................................................................................................................... 78
Section 2
Drugs Acting on Autonomic Nervous System
Autonomic Nervous System: General Considerations .......................................................................88
7. Cholinergic System and Drugs .................................................................................................................. 93
8. Anticholinergic Drugs and Drugs Acting on Autonomic Ganglia ................................................. 106
9. Adrenergic System and Drugs................................................................................................................ 116
10. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and
Drugs for Glaucoma ................................................................................................................................... 132
Section 3
Autacoids and Related Drugs
11. Histamine and Antihistaminics ............................................................................................................. 151
12. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine ..................................... 162
13. Prostaglandins, Leukotrienes (Eicosanoids) and Platelet Activating Factor .......................... 173
14. Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics .......................................... 184
,15. Antirheumatoid and Antigout Drugs .................................................................................................... 202
, Viii Contents
Section 4
Respiratory System Drugs
16. Drugs for Cough and Bronchial Asthma .............................................................................................. 213
Section 5
Hormones and Related Drugs
Introduction ................................................................................................................................................ 231
17. Anterior Pituitary Hormones.................................................................................................................. 233
18. Thyroid Hormone and Thyroid Inhibitors ......................................................................................... 242
19. Insulin, Oral Hypoglycaemic Drugs and Glucagon ........................................................................... 254
20. Corticosteroids ........................................................................................................................................... 275
21. Androgens and Drugs for Erectile Dysfunction ................................................................................ 288
22. Estrogens, Progestins and Contraceptives ......................................................................................... 297
23. Oxytocin and Other Drugs Acting on Uterus ...................................................................................... 319
24. Drugs Affecting Calcium Balance .......................................................................................................... 325
Section 6
Drugs Acting on Peripheral (Somatic) Nervous System
25. Skeletal Muscle Relaxants ....................................................................................................................... 339
26. Local Anaesthetics ..................................................................................................................................... 351
Section 7
Drugs Acting on Central Nervous System
27. General Anaesthetics ................................................................................................................................ 365
28. Ethyl and Methyl Alcohols ........................................................................................................................ 380
29. Sedative-Hypnotics.................................................................................................................................... 388
30. Antiepileptic Drugs .................................................................................................................................... 401
31. Antiparkinsonian Drugs .......................................................................................................................... 414
32. Drugs Used in Mental Illness: Antipsychotic and Antimanic Drugs ............................................ 423
33. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs ..................................... 439
34. Opioid Analgesics and Antagonists....................................................................................................... 453
35. CNS Stimulants and Cognition Enhancers........................................................................................... 469
Section 1
General Pharmacological Principles
1. Introduction, Routes of Drug Administration .........................................................................................3
2. Pharmacokinetics: Membrane Transport, Absorption and Distribution of Drugs ................. 11
3. Pharmacokinetics: Metabolism and Excretion of Drugs, Kinetics of Elimination .................... 23
4. Pharmacodynamics: Mechanism of Drug Action; Receptor Pharmacology .............................. 37
5. Aspects of Pharmacotherapy; Clinical Pharmacology and Drug Development ....................... 59
6. Adverse Drug Effects ................................................................................................................................... 78
Section 2
Drugs Acting on Autonomic Nervous System
Autonomic Nervous System: General Considerations .......................................................................88
7. Cholinergic System and Drugs .................................................................................................................. 93
8. Anticholinergic Drugs and Drugs Acting on Autonomic Ganglia ................................................. 106
9. Adrenergic System and Drugs................................................................................................................ 116
10. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and
Drugs for Glaucoma ................................................................................................................................... 132
Section 3
Autacoids and Related Drugs
11. Histamine and Antihistaminics ............................................................................................................. 151
12. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine ..................................... 162
13. Prostaglandins, Leukotrienes (Eicosanoids) and Platelet Activating Factor .......................... 173
14. Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics .......................................... 184
,15. Antirheumatoid and Antigout Drugs .................................................................................................... 202
, Viii Contents
Section 4
Respiratory System Drugs
16. Drugs for Cough and Bronchial Asthma .............................................................................................. 213
Section 5
Hormones and Related Drugs
Introduction ................................................................................................................................................ 231
17. Anterior Pituitary Hormones.................................................................................................................. 233
18. Thyroid Hormone and Thyroid Inhibitors ......................................................................................... 242
19. Insulin, Oral Hypoglycaemic Drugs and Glucagon ........................................................................... 254
20. Corticosteroids ........................................................................................................................................... 275
21. Androgens and Drugs for Erectile Dysfunction ................................................................................ 288
22. Estrogens, Progestins and Contraceptives ......................................................................................... 297
23. Oxytocin and Other Drugs Acting on Uterus ...................................................................................... 319
24. Drugs Affecting Calcium Balance .......................................................................................................... 325
Section 6
Drugs Acting on Peripheral (Somatic) Nervous System
25. Skeletal Muscle Relaxants ....................................................................................................................... 339
26. Local Anaesthetics ..................................................................................................................................... 351
Section 7
Drugs Acting on Central Nervous System
27. General Anaesthetics ................................................................................................................................ 365
28. Ethyl and Methyl Alcohols ........................................................................................................................ 380
29. Sedative-Hypnotics.................................................................................................................................... 388
30. Antiepileptic Drugs .................................................................................................................................... 401
31. Antiparkinsonian Drugs .......................................................................................................................... 414
32. Drugs Used in Mental Illness: Antipsychotic and Antimanic Drugs ............................................ 423
33. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs ..................................... 439
34. Opioid Analgesics and Antagonists....................................................................................................... 453
35. CNS Stimulants and Cognition Enhancers........................................................................................... 469
