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Terms in this set (194)
Type 1 hypersensitivity Mediated by antigen specific IgE and the products of
patho tissue mast cells
Type 1 hypersensitivity -Common allergic reactions
examples -Pollen, bees, nuts, medications
Type 2 hypersensitivity -Reaction against a specific cell
patho -IgG or IgM
Type 2 hypersensitivity -Mismatched blood transfusion reactions
examples -Hemolytic disease of the newborn
-Certain drug reactions
Type 3 hypersensitivity -Immune complex mediated
,patho -Complexes are formed in the circulation and
deposited later in vessel walls or tissues.
-Not organ specific
Type 3 hypersensitivity -Serum sickness -> Raynauds phenomenon
examples -Arthus reaction
, Type 4 hypersensitivity -Mediated by delayed T lymphocytes
patho -Cell-mediated
-No antibodies
Type 4 hypersensitivity -Poison ivy
examples -Graft rejection
-TB skin test
-Contact allergic reactions
Aging and immunity -Decreased T cell activity (thymus size is only
15% of max size) --Decreased production of
specific antibodies
-Increased circulation of antigen antibody
complexes-> travel through body and stick
somewhere.
-Immunosenescence -> decrease in
adaptive immunity due to changes in
immunity due to changes in lymphocyte
function and relative lymphocyte
population
-Decreased T & B cells
-Decreased circulating memory B cells
Neutrophils -Phagocytize pathogenic microbes and
remove debris and dead cells from lesions
-First to arrive at inflammation sites
What attracts neutrophils -Mast cell cytokines
-Chemokines
Phagocytosis -Ingestion of microbes, foreign particles, or cell