NEW!
BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION
KATZUNG TREVOR TEST BANK
INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS
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, Page 2 of 822 zl zl zl
Basic and Clinical Pharmacology 15th Edition Katzung Trevor Test Bank
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Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
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1.
A nurse working in radiology administers iodine to a patient who is having
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a computed tomography (CT) scan. The nurse working on the oncology unit
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administers chemotherapy to patients who have cancer. At the Public Health
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Department, a nurse administers a measles-mumps- zl zl zl zl zl
rubella (MMR) vaccine to a 14-month- zl zl zl zl zl
old child as a routine immunization. Which branch of pharmacology best des
zl zl zl zl zl zl zl zl zl zl zl
cribes the actions of all three nurses?
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A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses are in zl zl zl zl zl zl zl zl zl zl zl zl
volved with clinical pharmacology or pharmacotherapeutics, which is a bran
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ch of pharmacology that deals with the uses of drugs to treat, prevent, and di
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agnose disease. The radiology nurse is administering a drug to help diagnose
zl zl zl zl zl zl zl zl zl zl zl zl
a disease. The oncology nurse is administering a drug to help treat a disease.
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Pharmacoeconomics includes any costs involved in drug therapy. zl zl zl zl zl zl zl
Pharmacodynamics involves how a drug affects the body and pharmacokinetic zl zl zl zl zl zl zl zl zl
s is how the body acts on the body.
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2.
When involved in phase III drug evaluation studies, wh
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at responsibilities would the nurse have?
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A) Working with animals who are given experimental drugs
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B) Choosing appropriate patients to be involved in the drug study
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C) Monitoring and observing patients closely for adverse effects zl zl zl zl zl zl zl
D) Conducting research to determine effectiveness of the drug zl zl zl zl zl zl zl
, Page 3 of 822 zl zl zl
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in which p
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atients are asked to record any symptoms they experience while taking the dr
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ugs. Nurses may be responsible for helping collect and analyze the informati
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on to be shared with the Food and Drug Administration (FDA) but would not
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
conduct research independently because nurses do not prescribe medications
zl zl zl zl zl zl zl zl
. Use of animals in drug testing is done in the preclinical trials. Select patient
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s who are involved in phase II studies to participate in studies where the parti
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cipants have the disease the drug is intended to treat. These patients are moni
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tored closely for drug action and adverse effects. Phase I studies involve heal
zl zl zl zl zl zl zl zl zl zl zl zl
thy human volunteers who are usually paid for their participation. Nurses ma
zl zl zl zl zl zl zl zl zl zl zl
y observe for adverse effects and toxicity.
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3.
A physician has ordered intramuscular (IM) injections of morphine, a narc
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otic, every 4 hours as needed for pain in a motor vehicle accident victim. The
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nurse is aware this drug has a high abuse potential. Under what category wou
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ld morphine be classified?
zl zl zl
A) Schedule I zl
B) Schedule II zl
C) Schedule III zl
D) Schedule IV zl
Ans: B
Feedback:
Narcotics with a high abuse potential are classified as Schedule II drugs bec
zl zl zl zl zl zl zl zl zl zl zl zl
ause of severe dependence liability. Schedule I drugs have high abuse poten
zl zl zl zl zl zl zl zl zl zl zl
tial and no accepted medical use. Schedule III drugs have a lesser abuse pot
zl zl zl zl zl zl zl zl zl zl zl zl zl
ential than II and an accepted medical use. Schedule IV drugs have low abuse
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potential and limited dependence liability.
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4.
What concept is considered when generic drugs are substituted for bran
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d name drugs?
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A) Bioavailability
, Page 4 of 822 zl zl zl
B) Critical concentration zl
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug that reaches the systemic ci zl zl zl zl zl zl zl zl zl zl zl zl zl zl
rculation and is available to act on body cells. Binders used in a generic dru
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
g may not be the same as those used in the brand name drug. Therefore, the
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way the body breaks down and uses the drug may differ, which may elimin
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ate a generic drug substitution. Critical concentration is the amount of a drug
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that is needed to cause a therapeutic effect and should not differ between ge
zl zl zl zl zl zl zl zl zl zl zl zl zl
neric and brand name medications. Distribution is the phase of pharmacoki
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netics, which involves the movement of a drug to the bodys tissues and is th
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e same in generic and brand name drugs. A drugs half-
zl zl zl zl zl zl zl zl zl zl
life is the time it takes for the amount of drug to decrease to half the peak le
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vel, which should not change when substituting a generic medication.
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5.
A nurse is assessing the patients home medication use. After listening to th
zl zl zl zl zl zl zl zl zl zl zl zl
e patient list current medications, the nurse asks what priority question?
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A) Do you take any generic medications?
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B) Are any of these medications orphan drugs?
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C) Are these medications safe to take during pregnancy?
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D) Do you take any over-the-counter medications?
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Ans: D
Feedback:
It is important for the nurse to specifically question use of over-the-
zl zl zl zl zl zl zl zl zl zl zl
counter medications because patients may not consider them important. The
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patient is unlikely to know the meaning of orphan drugs unless they too are
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health care providers. Safety during pregnancy, use of a generic medication,
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or classification of orphan drugs are things the patient would be unable to an
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swer but could be found in reference books if the nurse wishes to research the
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m.
BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION
KATZUNG TREVOR TEST BANK
INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS
zl
, Page 2 of 822 zl zl zl
Basic and Clinical Pharmacology 15th Edition Katzung Trevor Test Bank
zl zl zl zl zl zl zl zl z l
Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
zl zl zl zl zl zl zl zl zl zl zl
1.
A nurse working in radiology administers iodine to a patient who is having
zl zl zl zl zl zl zl zl zl zl zl zl
a computed tomography (CT) scan. The nurse working on the oncology unit
zl zl zl zl zl zl zl zl zl zl zl zl zl
administers chemotherapy to patients who have cancer. At the Public Health
zl zl zl zl zl zl zl zl zl zl zl
Department, a nurse administers a measles-mumps- zl zl zl zl zl
rubella (MMR) vaccine to a 14-month- zl zl zl zl zl
old child as a routine immunization. Which branch of pharmacology best des
zl zl zl zl zl zl zl zl zl zl zl
cribes the actions of all three nurses?
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A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses are in zl zl zl zl zl zl zl zl zl zl zl zl
volved with clinical pharmacology or pharmacotherapeutics, which is a bran
zl zl zl zl zl zl zl zl zl
ch of pharmacology that deals with the uses of drugs to treat, prevent, and di
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
agnose disease. The radiology nurse is administering a drug to help diagnose
zl zl zl zl zl zl zl zl zl zl zl zl
a disease. The oncology nurse is administering a drug to help treat a disease.
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
Pharmacoeconomics includes any costs involved in drug therapy. zl zl zl zl zl zl zl
Pharmacodynamics involves how a drug affects the body and pharmacokinetic zl zl zl zl zl zl zl zl zl
s is how the body acts on the body.
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2.
When involved in phase III drug evaluation studies, wh
zl zl zl zl zl zl zl zl
at responsibilities would the nurse have?
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A) Working with animals who are given experimental drugs
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B) Choosing appropriate patients to be involved in the drug study
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C) Monitoring and observing patients closely for adverse effects zl zl zl zl zl zl zl
D) Conducting research to determine effectiveness of the drug zl zl zl zl zl zl zl
, Page 3 of 822 zl zl zl
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in which p
zl zl zl zl zl zl zl zl zl zl zl zl zl zl zl
atients are asked to record any symptoms they experience while taking the dr
zl zl zl zl zl zl zl zl zl zl zl zl
ugs. Nurses may be responsible for helping collect and analyze the informati
zl zl zl zl zl zl zl zl zl zl zl
on to be shared with the Food and Drug Administration (FDA) but would not
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
conduct research independently because nurses do not prescribe medications
zl zl zl zl zl zl zl zl
. Use of animals in drug testing is done in the preclinical trials. Select patient
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
s who are involved in phase II studies to participate in studies where the parti
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
cipants have the disease the drug is intended to treat. These patients are moni
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tored closely for drug action and adverse effects. Phase I studies involve heal
zl zl zl zl zl zl zl zl zl zl zl zl
thy human volunteers who are usually paid for their participation. Nurses ma
zl zl zl zl zl zl zl zl zl zl zl
y observe for adverse effects and toxicity.
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3.
A physician has ordered intramuscular (IM) injections of morphine, a narc
zl zl zl zl zl zl zl zl zl zl
otic, every 4 hours as needed for pain in a motor vehicle accident victim. The
zl zl zl zl zl zl zl zl zl zl zl zl zl zl zl
nurse is aware this drug has a high abuse potential. Under what category wou
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ld morphine be classified?
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A) Schedule I zl
B) Schedule II zl
C) Schedule III zl
D) Schedule IV zl
Ans: B
Feedback:
Narcotics with a high abuse potential are classified as Schedule II drugs bec
zl zl zl zl zl zl zl zl zl zl zl zl
ause of severe dependence liability. Schedule I drugs have high abuse poten
zl zl zl zl zl zl zl zl zl zl zl
tial and no accepted medical use. Schedule III drugs have a lesser abuse pot
zl zl zl zl zl zl zl zl zl zl zl zl zl
ential than II and an accepted medical use. Schedule IV drugs have low abuse
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potential and limited dependence liability.
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4.
What concept is considered when generic drugs are substituted for bran
zl zl zl zl zl zl zl zl zl zl
d name drugs?
zl zl
A) Bioavailability
, Page 4 of 822 zl zl zl
B) Critical concentration zl
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug that reaches the systemic ci zl zl zl zl zl zl zl zl zl zl zl zl zl zl
rculation and is available to act on body cells. Binders used in a generic dru
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
g may not be the same as those used in the brand name drug. Therefore, the
zl zl zl zl zl zl zl zl zl zl zl zl zl zl zl zl
way the body breaks down and uses the drug may differ, which may elimin
zl zl zl zl zl zl zl zl zl zl zl zl zl
ate a generic drug substitution. Critical concentration is the amount of a drug
zl zl zl zl zl zl zl zl zl zl zl zl zl
that is needed to cause a therapeutic effect and should not differ between ge
zl zl zl zl zl zl zl zl zl zl zl zl zl
neric and brand name medications. Distribution is the phase of pharmacoki
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netics, which involves the movement of a drug to the bodys tissues and is th
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
e same in generic and brand name drugs. A drugs half-
zl zl zl zl zl zl zl zl zl zl
life is the time it takes for the amount of drug to decrease to half the peak le
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vel, which should not change when substituting a generic medication.
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5.
A nurse is assessing the patients home medication use. After listening to th
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e patient list current medications, the nurse asks what priority question?
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A) Do you take any generic medications?
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B) Are any of these medications orphan drugs?
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C) Are these medications safe to take during pregnancy?
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D) Do you take any over-the-counter medications?
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Ans: D
Feedback:
It is important for the nurse to specifically question use of over-the-
zl zl zl zl zl zl zl zl zl zl zl
counter medications because patients may not consider them important. The
zl zl zl zl zl zl zl zl zl zl
patient is unlikely to know the meaning of orphan drugs unless they too are
zl zl zl zl zl zl zl zl zl zl zl zl zl zl
health care providers. Safety during pregnancy, use of a generic medication,
zl zl zl zl zl zl zl zl zl zl zl
or classification of orphan drugs are things the patient would be unable to an
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swer but could be found in reference books if the nurse wishes to research the
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m.
