GMS 6530 (MED PHARM II - CARDIO)- PROBLEM SET 5 QUESTIONS WITH COMPLETE SOLUTIONS VERIFIED GRADED A+

Would Amicar be expected to increase or decrease the presence of fibrin at blood
clots?


Increase
Decrease


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Increase




Patients suffering from hemophilia A lack Factor VIII. Which clotting pathway is
nonfunctional in these patients?


Intrinsic pathway
Extrinsic pathway


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, Intrinsic pathway




Which drug has irreversible effects on cells?


Warfarin
Aspirin
Heparin
Altepase
Amicar


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Aspirin




*FIBRINOLYTIC SYSTEM*


TISSUE-TYPE PLASMINOGEN ACTIVATOR (t-PA)


- CLOT-SELECTIVE
> Manufactured by means of recombinant DNA technology


- Directly converts plasminogen to plasma


- SHORT HALF-LIFE (5-8 mins)


USE:
- Myocardial infarction
- Acute ischemic stroke
- Massive pulmonary embolism


- NOT ANTIGENIC


- Can be used in PTs w antibodies to Streptokinase

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Alteplase




*DIRECT FACTOR Xa INHIBITORS*


ORAL direct factor Xa inhibitors


- Used for prophylaxis and treatment of deep vein thrombosis (DVT)
- There are NO ANTIDOTES for major bleeding events (NEED TO BE MONITORED)


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RivaroXAban (Xarelto)

ApiXAban (Eliquis)




Which drug is not given orally?


Lipitor
Zetia
Vytorin
Praluent
Lovaza


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Praluent