Fitzgerald Pharmacology Midterm Exam
Questions with Correct Answers
A drug's mechanism of action is part of its:
Pharmacokinetics.
Therapeutic transformation.
Pharmacodynamics.
Metabolism.
Pharmacodynamics
The process of absorption, distribution, metabolism and elimination of a drug is known
as:
Therapeutic transformation.
Drug interactions study.
Pharmacokinetics.
Pharmacodynamics.
Pharmacokinetics
Which of the following would best describe a pharmacodynamic study?
Determining the half-life of a specific medication dose
Determining the effect of a specific medication dose in treating a disease
Determining the Cmax of various medication doses
Determining the AUC of various medication doses
,Determining the effect of a specific medication dose in treating a disease
Cmax is best described as:
Percent of dose that enters systemic circulation after administration of a given dosage
form.
A plotted curve of drug plasma concentration versus time.
Biotransformation and/or excretion of oral drug by hepatic mechanisms prior to
entering GI tract.
Maximum or peak concentration of a drug observed after its administration.
Maximum or peak concentration of a drug observed after its administration.
When counseling a 56-year-old woman with type 2 diabetes mellitus, the NP mentions
which of the following regarding the use of semaglutide?
Identical A1C reduction is observed with the oral or injectable formulation
The oral form should be taken immediately following the first meal of the day
Tablets can be cut in half if a lower dose is needed
The oral dose of the medication needed is quite high compared to the injectable for due
to issues with GI absorption.
The oral dose of the medication needed is quite high compared to the injectable for due to
issues with GI absorption.
Tmax is best defined as:
Maximum or peak concentration of a drug observed after its administration.
The drug plasma concentration against time after a single dose drug administration.
,Time to maximum drug level is observed.
The process of passive diffusion.
Time to maximum drug level is observed.
7 of 10In the development, testing, and approval of a new medication, which of the
following best describes the question that is being asked in phase 3 testing?
Does the medication appear to have a clinical effect when subjected to a double-blind
clinical trial?
What is the drug's PK in healthy volunteers?
What are the results of post-marketing surveillance?
How does the medication work in laboratory animals?
Does the medication appear to have a clinical effect when subjected to a double-blind clinical
trial?
Age-related changes in the elder include all of the following except:
Total body water decreases.
Body weight as fat increases.
Increase in serum albumin.
Decrease in kidney weight.
Increase in serum albumin.
When considering the movement of drugs throughout the body, it is important to
consider that the most common form of drug absorption is via:
Active transport.
, Facilitated transfer.
Passive diffusion.
Creation of a pH gradient.
Passive diffusion.
The safety and pharmacokinetics of a new drug are best determined in which phase of
clinical trials?
Pre-clinical
Phase 1
Phase 2
Phase 3
Phase 1
Bioavailability is defined as the:
Solubility of the drug.
Fraction of the administered drug that reaches systemic circulation.
The drug's alkalinity or acidity.
Protein-bound fraction of a drug.
Fraction of the administered drug that reaches systemic circulation.
A nursing mother is taking a medication with a 2-hour half-life and is concerned about
her infant ingesting some of the drug through breastmilk. The NP knows that <10% of
the original drug dose will remain in the body after how many hours following her
dose?
Questions with Correct Answers
A drug's mechanism of action is part of its:
Pharmacokinetics.
Therapeutic transformation.
Pharmacodynamics.
Metabolism.
Pharmacodynamics
The process of absorption, distribution, metabolism and elimination of a drug is known
as:
Therapeutic transformation.
Drug interactions study.
Pharmacokinetics.
Pharmacodynamics.
Pharmacokinetics
Which of the following would best describe a pharmacodynamic study?
Determining the half-life of a specific medication dose
Determining the effect of a specific medication dose in treating a disease
Determining the Cmax of various medication doses
Determining the AUC of various medication doses
,Determining the effect of a specific medication dose in treating a disease
Cmax is best described as:
Percent of dose that enters systemic circulation after administration of a given dosage
form.
A plotted curve of drug plasma concentration versus time.
Biotransformation and/or excretion of oral drug by hepatic mechanisms prior to
entering GI tract.
Maximum or peak concentration of a drug observed after its administration.
Maximum or peak concentration of a drug observed after its administration.
When counseling a 56-year-old woman with type 2 diabetes mellitus, the NP mentions
which of the following regarding the use of semaglutide?
Identical A1C reduction is observed with the oral or injectable formulation
The oral form should be taken immediately following the first meal of the day
Tablets can be cut in half if a lower dose is needed
The oral dose of the medication needed is quite high compared to the injectable for due
to issues with GI absorption.
The oral dose of the medication needed is quite high compared to the injectable for due to
issues with GI absorption.
Tmax is best defined as:
Maximum or peak concentration of a drug observed after its administration.
The drug plasma concentration against time after a single dose drug administration.
,Time to maximum drug level is observed.
The process of passive diffusion.
Time to maximum drug level is observed.
7 of 10In the development, testing, and approval of a new medication, which of the
following best describes the question that is being asked in phase 3 testing?
Does the medication appear to have a clinical effect when subjected to a double-blind
clinical trial?
What is the drug's PK in healthy volunteers?
What are the results of post-marketing surveillance?
How does the medication work in laboratory animals?
Does the medication appear to have a clinical effect when subjected to a double-blind clinical
trial?
Age-related changes in the elder include all of the following except:
Total body water decreases.
Body weight as fat increases.
Increase in serum albumin.
Decrease in kidney weight.
Increase in serum albumin.
When considering the movement of drugs throughout the body, it is important to
consider that the most common form of drug absorption is via:
Active transport.
, Facilitated transfer.
Passive diffusion.
Creation of a pH gradient.
Passive diffusion.
The safety and pharmacokinetics of a new drug are best determined in which phase of
clinical trials?
Pre-clinical
Phase 1
Phase 2
Phase 3
Phase 1
Bioavailability is defined as the:
Solubility of the drug.
Fraction of the administered drug that reaches systemic circulation.
The drug's alkalinity or acidity.
Protein-bound fraction of a drug.
Fraction of the administered drug that reaches systemic circulation.
A nursing mother is taking a medication with a 2-hour half-life and is concerned about
her infant ingesting some of the drug through breastmilk. The NP knows that <10% of
the original drug dose will remain in the body after how many hours following her
dose?
