CLINICAL CHEMISTRY I ASCP COMPREHENSIVE EXAM SCRIPT COMPLETE QUESTIONS VERIFIED SOLUTIONS

CLINICAL CHEMISTRY I ASCP COMPREHENSIVE EXAM SCRIPT COMPLETE QUESTIONS
VERIFIED SOLUTIONS
Clinical Chemistry I ASCP EXAM Script 2026/2027
Questions and Answers Verified Solutions Latest
Update

Question:
a pregnant woman became nauseated and vomited 90 minutes after receiving a standard 50g
carbohydrate dose for an oral glucose tolerance test. what is the best course of action?

Answer:
draw blood for glucose and discontinue the test



Question:
which of the following 2 hour post prandial glucose values demonstrates unequivocal
hyperglycemia diagnostic for diabetes mellitus? 155 mg/dL 170 mg/dL 185 mg/dL 200 mg/dL

Answer:
200 mg/dL



Question:
a 41 year old woman had the following lab results 6 hours after eating triglycerides- 280 mg/dL
cholesterol- 140 mg/dL

Answer:
triglycerides are elevated, which may be attributed to the recent meal



Question:
in HDL-c analysis, cloudy or floating particulates in the supernatant will most likely cause which of
the following

Answer:
falsely increased HDL cholesterol

,Question:
which LDL-c level exceeds the cutoff for coronary heart disease high risk? 168 mg/dL 154 mg/dL
126 mg/dL 105 mg/dL

Answer:
168 mg/dL



Question:
what reagent is added to accelerate the diazo reaction with conjugated bilirubin to form a
chromogen

Answer:
caffeine-sodium benzoate



Question:
a serum total bilirubin concentration of 5.4 mg/dL and a conjugated bilirubin conc of 4.9 mg/dL
with a 4+ urine bilirubin but a negative urine urobilinogen result is associated with which of the
following hepatitis hemolytic disease gilbert disease cholestasis/cholelithiasis

Answer:
cholestasis/cholelithiasis



Question:
what is ht emost commonly used method in clinical laboratories for CKMB testing

Answer:
immunoinhibition immunoassay



Question:
an oncology pt undergoing treatment has a carcinoembyonic antigen (CEA) level of 15ng/mL
(reference range <10). what does this indicate?

,Answer:
recurrence of colorectal cancer



Question:
interference due to glucose, ascorbate, and alpha ketoacids can be minimized in analysis of
creatinine by what?

Answer:
using the kinetic jaffe method



Question:
a plasma ammonia result of 150 ug/dL (reference range, 19-55) in a pediatric patient likely indicates
which of the following? prehepatic disorders prerenal disorders renal failure hepatic failure

Answer:
hepatic failure



Question:
when measuring thyroxine (T4) by fluorescent polarization immunoassay, which of the following is
true? T4 binds to specific antibody to t4 bound to microtiter plate there is no separation or wash step
fluorescent-labeled drug competes with patient T4 for polarized antibody reaction time is slower
than radioimmunoassay (RIA) but fluorescent polarization immunoassay is more common owing to
safety issues with RIA

Answer:
there is no separation or wash step



Question:
which of the following is reversibly bound to a cellophane membrane impregnated with special
molecules which develops a potential compared to the internal silver electrode? K+, Mg++, Cl,
Ca++

Answer:

, Ca++



Question:
a patient has increased serum phosphorus, decreased plasma free calcium, and decreased urinary
phosphorus. this correlates with which of the following?

Answer:
primary hypoparathyroidism



Question:
for therapeutic drug monitoring, how should the specimen be handled?

Answer:
mixed well to distribute heparin throughout before centrifugation



Question:
in reverse-phase high-performance liquid chromatography for therapeutic drug monitoring, the term
reverse phase implies that the column eluate is which of the following?

Answer:
more polar than the stationary phase



Question:
when analyzing urine specimens for drugs of abuse testing, immunoassay is the method of choice
for screening. what is the method of choice for confirmation?

Answer:
gas chromatography/mass spec



Question:
glycolysis