BIOL 252 Human Anatomy &
Physiology II w/Lab | Module 1 Blood
and Heart Exam 100+ Practice
Questions and Answers 2025-2026
1. Which organ is the primary pump of the cardiovascular system?
A. Lung
B. Liver
C. Heart
D. Kidney
Answer: C. Heart
Rationale: The heart generates the force needed to circulate blood
throughout the body.
2. The cardiovascular system consists of the:
A. Heart and lungs only
B. Blood vessels only
C. Heart, blood, and blood vessels
D. Blood and kidneys
Answer: C. Heart, blood, and blood vessels
Rationale: These three components work together to transport
oxygen, nutrients, hormones, and wastes.
3. Which chamber of the heart pumps oxygenated blood into the
systemic circulation?
,A. Right atrium
B. Right ventricle
C. Left atrium
D. Left ventricle
Answer: D. Left ventricle
Rationale: The left ventricle ejects oxygen-rich blood through the
aorta to the body.
4. The right atrium receives blood from the:
A. Pulmonary veins
B. Aorta
C. Superior and inferior vena cava
D. Pulmonary artery
Answer: C. Superior and inferior vena cava
Rationale: These veins return deoxygenated blood from the systemic
circulation.
5. Blood leaves the right ventricle through the:
A. Aorta
B. Pulmonary trunk
C. Superior vena cava
D. Pulmonary veins
Answer: B. Pulmonary trunk
Rationale: The pulmonary trunk carries deoxygenated blood to the
lungs.
,6. Which vessel carries oxygenated blood back to the heart from
the lungs?
A. Pulmonary artery
B. Superior vena cava
C. Inferior vena cava
D. Pulmonary veins
Answer: D. Pulmonary veins
Rationale: Pulmonary veins are unique because they carry oxygen-
rich blood.
7. The heart is enclosed by the:
A. Pleura
B. Peritoneum
C. Pericardium
D. Endocardium
Answer: C. Pericardium
Rationale: The pericardium is the protective sac surrounding the
heart.
8. Which layer forms the muscular wall of the heart?
A. Epicardium
B. Endocardium
C. Pericardium
D. Myocardium
Answer: D. Myocardium
Rationale: The myocardium contracts to pump blood.
, 9. Which heart valve prevents backflow into the right atrium?
A. Mitral valve
B. Aortic valve
C. Pulmonary valve
D. Tricuspid valve
Answer: D. Tricuspid valve
Rationale: The tricuspid valve separates the right atrium and right
ventricle.
10. The bicuspid valve is also called the:
A. Tricuspid valve
B. Pulmonary valve
C. Mitral valve
D. Aortic valve
Answer: C. Mitral valve
Rationale: The mitral valve controls blood flow between the left
atrium and left ventricle.
11. Which valve prevents blood from flowing back into the left
ventricle?
A. Pulmonary valve
B. Tricuspid valve
C. Mitral valve
D. Aortic semilunar valve
Answer: D. Aortic semilunar valve
Rationale: The aortic valve closes after ventricular contraction.
Physiology II w/Lab | Module 1 Blood
and Heart Exam 100+ Practice
Questions and Answers 2025-2026
1. Which organ is the primary pump of the cardiovascular system?
A. Lung
B. Liver
C. Heart
D. Kidney
Answer: C. Heart
Rationale: The heart generates the force needed to circulate blood
throughout the body.
2. The cardiovascular system consists of the:
A. Heart and lungs only
B. Blood vessels only
C. Heart, blood, and blood vessels
D. Blood and kidneys
Answer: C. Heart, blood, and blood vessels
Rationale: These three components work together to transport
oxygen, nutrients, hormones, and wastes.
3. Which chamber of the heart pumps oxygenated blood into the
systemic circulation?
,A. Right atrium
B. Right ventricle
C. Left atrium
D. Left ventricle
Answer: D. Left ventricle
Rationale: The left ventricle ejects oxygen-rich blood through the
aorta to the body.
4. The right atrium receives blood from the:
A. Pulmonary veins
B. Aorta
C. Superior and inferior vena cava
D. Pulmonary artery
Answer: C. Superior and inferior vena cava
Rationale: These veins return deoxygenated blood from the systemic
circulation.
5. Blood leaves the right ventricle through the:
A. Aorta
B. Pulmonary trunk
C. Superior vena cava
D. Pulmonary veins
Answer: B. Pulmonary trunk
Rationale: The pulmonary trunk carries deoxygenated blood to the
lungs.
,6. Which vessel carries oxygenated blood back to the heart from
the lungs?
A. Pulmonary artery
B. Superior vena cava
C. Inferior vena cava
D. Pulmonary veins
Answer: D. Pulmonary veins
Rationale: Pulmonary veins are unique because they carry oxygen-
rich blood.
7. The heart is enclosed by the:
A. Pleura
B. Peritoneum
C. Pericardium
D. Endocardium
Answer: C. Pericardium
Rationale: The pericardium is the protective sac surrounding the
heart.
8. Which layer forms the muscular wall of the heart?
A. Epicardium
B. Endocardium
C. Pericardium
D. Myocardium
Answer: D. Myocardium
Rationale: The myocardium contracts to pump blood.
, 9. Which heart valve prevents backflow into the right atrium?
A. Mitral valve
B. Aortic valve
C. Pulmonary valve
D. Tricuspid valve
Answer: D. Tricuspid valve
Rationale: The tricuspid valve separates the right atrium and right
ventricle.
10. The bicuspid valve is also called the:
A. Tricuspid valve
B. Pulmonary valve
C. Mitral valve
D. Aortic valve
Answer: C. Mitral valve
Rationale: The mitral valve controls blood flow between the left
atrium and left ventricle.
11. Which valve prevents blood from flowing back into the left
ventricle?
A. Pulmonary valve
B. Tricuspid valve
C. Mitral valve
D. Aortic semilunar valve
Answer: D. Aortic semilunar valve
Rationale: The aortic valve closes after ventricular contraction.
