CERTIFIED QUESTIONS AND ANSWERS HIGHLY
ADVANCED 2026/2027
Penicillinase-resistant penicillins - ANSWER-Oxacillin, nafcillin, dicloxacillin
broad spectrum penicillins - ANSWER-- ampicillin and amoxicillin
- good oral absorption (amoxicillin = excellent)
- broad spectrum (improved against gram negative organisms - e.coli, salmonella, shingella,
H. Influenza, H pylori, proteus)
How do penicillins and cephalosporins work? - ANSWER-By weakening the cell wall and
promoting lysis and death
Bactericidal drugs are - ANSWER-Directly lethal to bacteria at achievable concentrations
Why are narrow spectrum drugs preferred over broad spectrum antibiotics? - ANSWER-
Broad spectrum antibiotics do the most to facilitate emergence of resistance
How does bacterial resistance develop with penicillins? - ANSWER--production of penicillin
binding proteins that have low affinity for penicillins
-inability of penicillins to reach their target
-inactivation of penicillins by bacterial enzymes
, Mary is a 20 year old female you have diagnosed him with strep throat. She has had an
anaphylactic reaction to penicillin. Which of the following antibiotics is appropriate for
Mary? - ANSWER-Azithromycin
What are penicillinases? - ANSWER-Beta-lactamases that act selectively on penicillins
The following are Penicillinases-resistant penicillins - ANSWER-Oxacillin, Dicloxacillin,
Nafcillin
The following are broad spectrum penicillins (aminopenicillins) - ANSWER-Amoxicillin and
ampicillin
The following are extended-spectrum penicillins (antipseudomonal) - ANSWER-Ticarcillin
and Piperacillin
The following are beta-lactamase inhibitors - ANSWER-Sulbactam, tazobactam and
clavilanic acid
Which cephalosporins are rarely used for active infections? - ANSWER-Second generation
Jack is taking Coumadin for his atrial fibrillation. Which of the following cephalosporins
should not be prescribed for jack? - ANSWER-Ceftriaxone and cefotetan
Third generation cephalosporins are good to treat - ANSWER-Meningitis
Fourth Generation Cephalosporins are good to treat? - ANSWER-Pneumonia
Vancomycin works by - ANSWER-Inhibiting Cell wall synthesis
Fluroquinolones work by - ANSWER-Disrupting DNA replication and cell revision
Jackson has community acquired pneumonia mycoplasma pneumonia's is suspected.
Which of the following is the best choice for treatment? - ANSWER-Doxycycline
Michael is taking simvastin for his cholesterol. Which antibiotic should not be prescribed? -
ANSWER-Erythromycin
What can you prescribe for prophylaxis in recurring UTIs - ANSWER-Sulfamethoxazole
trimethoprim 3 times a week for 6 months
What organisms are the most causative for UTIs - ANSWER-E. Coli, Klebsiella, proteus
What drug can be used for postcoital UTIs - ANSWER-Nitrofurantoin 100 mg after
intercourse