NURS 5338 CP2 EXAM / ACTUAL NURS 5338 CP2 FINAL EXAM
2026/2027 PRACTICE QUESTIONS AND STUDY GUIDE COMPLETE
ACCURATE EXAM APPROVED QUESTIONS WITH WELL
ELABORATED ANSWERS AND DETAILED RATIONALES (100%
CORRECT VERIFIED SOLUTIONS) CURRENTLY UPDATED
VERSION 2026 EDITION |FULL REVISED NURS 5338 REAL FINAL
EXAM |JUST RELEASED
1. A patient is prescribed a weak acid with a pKa of 4.5. In which
body compartment will this drug primarily be absorbed?
A) Stomach (pH 1.5-2.0)
B) Small intestine (pH 6.0-7.5)
C) Blood (pH 7.35-7.45)
D) Urine (pH 5.0-8.0)
Correct Answer: A
Rationale: Weak acids are non-ionized (lipid-soluble) and well absorbed
in acidic environments. Using the Henderson-Hasselbalch equation, when
pH < pKa, the acidic drug is predominantly non-ionized (HA), favoring
absorption. Stomach pH (1.5-2.0) is below the pKa of 4.5, so the drug
will be mostly non-ionized and well absorbed. Weak bases are better
absorbed in the intestine.
2. A patient is taking two drugs that are highly protein-bound (98%
each). Which pharmacokinetic phenomenon is most likely to occur?
A) Decreased drug half-life
B) Drug displacement and increased free drug concentration
C) Increased renal excretion
,D) Decreased volume of distribution
Correct Answer: B
Rationale: When two highly protein-bound drugs are co-administered,
they compete for binding sites on plasma proteins. Displacement of one
drug by the other leads to an increase in the free (unbound) concentration
of the displaced drug, which can enhance its pharmacological effect and
potentially cause toxicity.
3. A drug that is a strong CYP3A4 inducer would be expected to:
A) Increase the levels of other drugs metabolized by CYP3A4
B) Decrease the levels of other drugs metabolized by CYP3A4
C) Have no effect on drug metabolism
D) Increase its own metabolism only
Correct Answer: B
Rationale: CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
increase the expression and activity of the CYP3A4 enzyme, leading to
enhanced metabolism and decreased plasma levels of other drugs that are
substrates for this enzyme. This can result in reduced therapeutic efficacy
of the affected drugs.
4. Which of the following is NOT FDA-approved for smoking
cessation?
A) Varenicline
B) Bupropion
C) Nortriptyline
,D) Nicotine lozenge
Correct Answer: C
Rationale: Nortriptyline is a tricyclic antidepressant that is used off-label
for smoking cessation. Varenicline, bupropion, and nicotine replacement
therapies (including lozenges) are FDA-approved for this indication.
5. A patient states, "I will quit smoking next month." According to
the Transtheoretical Model of Change, which stage is this patient in?
A) Precontemplation
B) Contemplation
C) Preparation
D) Maintenance
Correct Answer: C
Rationale: The preparation stage is characterized by the intention to take
action within the next 30 days, often accompanied by some small
behavioral changes. Planning to quit within 30 days indicates the
preparation stage.
6. What is the primary goal of motivational interviewing?
A) Confront the patient about their unhealthy behaviors
B) Educate the patient on the risks of their behaviors
C) Enhance intrinsic motivation for change
D) Set rigid, non-negotiable goals for the patient
Correct Answer: C
, Rationale: The primary goal of motivational interviewing is to elicit and
strengthen the patient's own intrinsic motivation for change. It is a
patient-centered, collaborative approach that avoids confrontation and
focuses on resolving ambivalence.
7. Which of the following is a motivational interviewing technique?
A) Advice-giving
B) Closed questions
C) Open-ended questions
D) Rapid questioning
Correct Answer: C
Rationale: Open-ended questions are a core technique in motivational
interviewing. They encourage the patient to elaborate, explore their own
thoughts and feelings, and promote discussion. Closed questions, advice-
giving, and rapid questioning are generally not recommended in
motivational interviewing.
8. According to the American College of Sports Medicine (ACSM)
and the American Heart Association (AHA), what is the
recommended amount of moderate-intensity aerobic exercise per
week for most adults?
A) 60 minutes
B) 90 minutes
C) 150 minutes
D) 200 minutes
Correct Answer: C
2026/2027 PRACTICE QUESTIONS AND STUDY GUIDE COMPLETE
ACCURATE EXAM APPROVED QUESTIONS WITH WELL
ELABORATED ANSWERS AND DETAILED RATIONALES (100%
CORRECT VERIFIED SOLUTIONS) CURRENTLY UPDATED
VERSION 2026 EDITION |FULL REVISED NURS 5338 REAL FINAL
EXAM |JUST RELEASED
1. A patient is prescribed a weak acid with a pKa of 4.5. In which
body compartment will this drug primarily be absorbed?
A) Stomach (pH 1.5-2.0)
B) Small intestine (pH 6.0-7.5)
C) Blood (pH 7.35-7.45)
D) Urine (pH 5.0-8.0)
Correct Answer: A
Rationale: Weak acids are non-ionized (lipid-soluble) and well absorbed
in acidic environments. Using the Henderson-Hasselbalch equation, when
pH < pKa, the acidic drug is predominantly non-ionized (HA), favoring
absorption. Stomach pH (1.5-2.0) is below the pKa of 4.5, so the drug
will be mostly non-ionized and well absorbed. Weak bases are better
absorbed in the intestine.
2. A patient is taking two drugs that are highly protein-bound (98%
each). Which pharmacokinetic phenomenon is most likely to occur?
A) Decreased drug half-life
B) Drug displacement and increased free drug concentration
C) Increased renal excretion
,D) Decreased volume of distribution
Correct Answer: B
Rationale: When two highly protein-bound drugs are co-administered,
they compete for binding sites on plasma proteins. Displacement of one
drug by the other leads to an increase in the free (unbound) concentration
of the displaced drug, which can enhance its pharmacological effect and
potentially cause toxicity.
3. A drug that is a strong CYP3A4 inducer would be expected to:
A) Increase the levels of other drugs metabolized by CYP3A4
B) Decrease the levels of other drugs metabolized by CYP3A4
C) Have no effect on drug metabolism
D) Increase its own metabolism only
Correct Answer: B
Rationale: CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
increase the expression and activity of the CYP3A4 enzyme, leading to
enhanced metabolism and decreased plasma levels of other drugs that are
substrates for this enzyme. This can result in reduced therapeutic efficacy
of the affected drugs.
4. Which of the following is NOT FDA-approved for smoking
cessation?
A) Varenicline
B) Bupropion
C) Nortriptyline
,D) Nicotine lozenge
Correct Answer: C
Rationale: Nortriptyline is a tricyclic antidepressant that is used off-label
for smoking cessation. Varenicline, bupropion, and nicotine replacement
therapies (including lozenges) are FDA-approved for this indication.
5. A patient states, "I will quit smoking next month." According to
the Transtheoretical Model of Change, which stage is this patient in?
A) Precontemplation
B) Contemplation
C) Preparation
D) Maintenance
Correct Answer: C
Rationale: The preparation stage is characterized by the intention to take
action within the next 30 days, often accompanied by some small
behavioral changes. Planning to quit within 30 days indicates the
preparation stage.
6. What is the primary goal of motivational interviewing?
A) Confront the patient about their unhealthy behaviors
B) Educate the patient on the risks of their behaviors
C) Enhance intrinsic motivation for change
D) Set rigid, non-negotiable goals for the patient
Correct Answer: C
, Rationale: The primary goal of motivational interviewing is to elicit and
strengthen the patient's own intrinsic motivation for change. It is a
patient-centered, collaborative approach that avoids confrontation and
focuses on resolving ambivalence.
7. Which of the following is a motivational interviewing technique?
A) Advice-giving
B) Closed questions
C) Open-ended questions
D) Rapid questioning
Correct Answer: C
Rationale: Open-ended questions are a core technique in motivational
interviewing. They encourage the patient to elaborate, explore their own
thoughts and feelings, and promote discussion. Closed questions, advice-
giving, and rapid questioning are generally not recommended in
motivational interviewing.
8. According to the American College of Sports Medicine (ACSM)
and the American Heart Association (AHA), what is the
recommended amount of moderate-intensity aerobic exercise per
week for most adults?
A) 60 minutes
B) 90 minutes
C) 150 minutes
D) 200 minutes
Correct Answer: C
