AANP Pharmacology review board certification
Study online at https://quizlet.com/_9r1zmy
1. The amount of time in which a drug concentration half life
decreases by 50%
2. the average amount of a drug in the blood after a dose Area under the curve
is given it is a measure of the availability of a drug after
it is administered
3. What is the most active organ for metabolism of med- CYPP450 and the liver
icine and what enzyme system is used?
4. The Lowest concentration of an antibiotic that will Minimum inhibitory con-
inhibit the growth of organisms (after overnight incu- centration
bation)
5. The highest concentration of drug after a dose Maximum concentration
6. The lowest concentration of a drug after a dose Trough (minimum con-
centration)
7. These drugs are "problematic" they are responsible Macrolides: erythromycin,
for a lot of drug to drug interactions, slow down drug clarithryomycin
clearence. Antifungals: ketoconazole,
fluconazole
Cimetidine: tagamet
Citalopram: Celexa
8. What drugs are affected by grapefruit juice? statins
erythromycin
CCB
antivirals
amiodarone
benzos
, AANP Pharmacology review board certification
Study online at https://quizlet.com/_9r1zmy
cisapride
buspirone
9. Monitor INR Warfarin
10. monitor lvl, EKG, potassium, mag, and calcium Digoxin (Lanoxin)
11. Monitor blood levels Theophylline, Carba-
mazepine, Phenytoin
12. Monitor TSH Levothyroxine
13. Monitor blood lvls, TSH (hypo) Lithium
14. Increased risk of Fractures in postmenopuasal Proton pump inhibitors
women, pneumonia, C diff infection, hypomagne-
sium, B12 and iron malabsorption, gastritis, kidney
disease
15. interacts with warfarin, diazepam, carbamazepine, Omeprazole (prilosec)
phenytoin, ketoconazole
16. Interacts with "G" herbs: garlic, ginger, gingko, gin- Warfarin (coumadin) vit. K
seng and other herbs: feverfew, green tea, and fish oil. agonist
D/C 7 days before surgery
17. Black box warning: cause or exacerbate CHF in some TZD's
patients, do not use in class 3 or class 4 heart failure
18. stop if causes dyspnea, weight gain, cough (heart fail- Pioglitazone (actos)
ure)
19. Risperidone (risperdal)
Olanzapine (zyprexa)
, AANP Pharmacology review board certification
Study online at https://quizlet.com/_9r1zmy
High risk of weight gain, metabolic syndrome, type 2
diabetes, monitor weight q3 months. HIGHER MOR-
TALITY IN ELDERLY PATIENTS
20. Monitor TSH, lipids, weight/body mass index Quetiapine (seroquel)
21. erosive esophagitis, abdominal pain, stop immediate- bisphosphonates
ly if symptoms of esophagitis or jaw pain, take alone
upon awakening with 8 oz glass water before break-
fast, do not lie down 30 minutes afterwards, do not
mix with other drugs, take first thing in the morning
22. Contraindications: Active GI disease (GERD, PUD), Alendronate (fosamax)
CKD, exophageal stricture/varices Risedronate (Actonel)
23. Do not mix with grapefruit juice, drug induced he- statins
patitis or rhabdomylosis higher if mixed with azole
antifungals
24. higher doses 80mg has risk of rhabdomylosis, Chi- Simvastatin (zocor)
nese descent higher risk myopathy or rhabdomyolysis
when taking higher then 40mg. Creatine kinase level
goes up.
25. high risk of CDAD Lincosamides
Clindamycin
26. Treats certain supraventricular tachyarrhythmias and Digoxin
heart failure (HF) due to left ventricular [LV] systolic
dysfunction
has a narrow therapeutic range (0.5-2.0 ng/mL). Not a
first-line drug for heart rate control in most patients
with atrial fibrillation
Study online at https://quizlet.com/_9r1zmy
1. The amount of time in which a drug concentration half life
decreases by 50%
2. the average amount of a drug in the blood after a dose Area under the curve
is given it is a measure of the availability of a drug after
it is administered
3. What is the most active organ for metabolism of med- CYPP450 and the liver
icine and what enzyme system is used?
4. The Lowest concentration of an antibiotic that will Minimum inhibitory con-
inhibit the growth of organisms (after overnight incu- centration
bation)
5. The highest concentration of drug after a dose Maximum concentration
6. The lowest concentration of a drug after a dose Trough (minimum con-
centration)
7. These drugs are "problematic" they are responsible Macrolides: erythromycin,
for a lot of drug to drug interactions, slow down drug clarithryomycin
clearence. Antifungals: ketoconazole,
fluconazole
Cimetidine: tagamet
Citalopram: Celexa
8. What drugs are affected by grapefruit juice? statins
erythromycin
CCB
antivirals
amiodarone
benzos
, AANP Pharmacology review board certification
Study online at https://quizlet.com/_9r1zmy
cisapride
buspirone
9. Monitor INR Warfarin
10. monitor lvl, EKG, potassium, mag, and calcium Digoxin (Lanoxin)
11. Monitor blood levels Theophylline, Carba-
mazepine, Phenytoin
12. Monitor TSH Levothyroxine
13. Monitor blood lvls, TSH (hypo) Lithium
14. Increased risk of Fractures in postmenopuasal Proton pump inhibitors
women, pneumonia, C diff infection, hypomagne-
sium, B12 and iron malabsorption, gastritis, kidney
disease
15. interacts with warfarin, diazepam, carbamazepine, Omeprazole (prilosec)
phenytoin, ketoconazole
16. Interacts with "G" herbs: garlic, ginger, gingko, gin- Warfarin (coumadin) vit. K
seng and other herbs: feverfew, green tea, and fish oil. agonist
D/C 7 days before surgery
17. Black box warning: cause or exacerbate CHF in some TZD's
patients, do not use in class 3 or class 4 heart failure
18. stop if causes dyspnea, weight gain, cough (heart fail- Pioglitazone (actos)
ure)
19. Risperidone (risperdal)
Olanzapine (zyprexa)
, AANP Pharmacology review board certification
Study online at https://quizlet.com/_9r1zmy
High risk of weight gain, metabolic syndrome, type 2
diabetes, monitor weight q3 months. HIGHER MOR-
TALITY IN ELDERLY PATIENTS
20. Monitor TSH, lipids, weight/body mass index Quetiapine (seroquel)
21. erosive esophagitis, abdominal pain, stop immediate- bisphosphonates
ly if symptoms of esophagitis or jaw pain, take alone
upon awakening with 8 oz glass water before break-
fast, do not lie down 30 minutes afterwards, do not
mix with other drugs, take first thing in the morning
22. Contraindications: Active GI disease (GERD, PUD), Alendronate (fosamax)
CKD, exophageal stricture/varices Risedronate (Actonel)
23. Do not mix with grapefruit juice, drug induced he- statins
patitis or rhabdomylosis higher if mixed with azole
antifungals
24. higher doses 80mg has risk of rhabdomylosis, Chi- Simvastatin (zocor)
nese descent higher risk myopathy or rhabdomyolysis
when taking higher then 40mg. Creatine kinase level
goes up.
25. high risk of CDAD Lincosamides
Clindamycin
26. Treats certain supraventricular tachyarrhythmias and Digoxin
heart failure (HF) due to left ventricular [LV] systolic
dysfunction
has a narrow therapeutic range (0.5-2.0 ng/mL). Not a
first-line drug for heart rate control in most patients
with atrial fibrillation
